Results 61 to 70 of about 9,710 (220)

From Undifferentiated Connective Tissue Disease to Common Variable Immunodeficiency: A Novel NFKB1 Mutation in a Pediatric Case

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Common variable immunodeficiency (CVID) may initially manifest as undifferentiated connective tissue disease (UCTD) in the absence of recurrent infections or hypogammaglobulinemia. In patients presenting with warning signs, neither older age nor normal immunoglobulin levels should preclude consideration of CVID; early genetic testing is ...
Yu‐Jie Hu, Sheng Hao, Dan Feng, Bing‐Xue Huang, Wen‐Yan Huang   +4 more
wiley   +1 more source

HBx-Induced NF-κB Signaling in Liver Cells Is Potentially Mediated by the Ternary Complex of HBx with p22-FLIP and NEMO

PLoS ONE, 2013
Sustained activation of NF-κB is one of the causative factors for various liver diseases, including liver inflammation and hepatocellular carcinoma (HCC). It has been known that activating the NF-κB signal by hepatitis B virus X protein (HBx) is implicated in the development of HCC. However, despite numerous studies on HBx-induced NF-κB activation, the
Keo-Heun Lim, Hyo Sun Choi, Yong Kwang Park, Eun-Sook Park, Gu Choul Shin, Doo Hyun Kim, Sung Hyun Ahn, Kyun-Hwan Kim   +7 more
openaire   +4 more sources

Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: an alternative mechanism of HBx-related pathogenesis [PDF]

, 2002
The role of the hepatitis B virus X protein (HBx) in the pathogenesis of hepatitis B virus (HBV) infection remains unclear. HBx exhibits pleiotropic biological effects, whose in vivo relevance is a matter for debate. In the present report, we have used a
Bréchot, C, Tralhao, JG, Tu, H, Roudier, J, Goulenok, C, Joulin, V, Kremsdorf, D, Carnot, F, Morosan, S, Zavala, F, Giannini, C   +10 more
core   +1 more source

Identifying and Characterizing Interplay between Hepatitis B Virus X Protein and Smc5/6

Viruses, 2017
Hepatitis B X protein (HBx) plays an essential role in the hepatitis B virus (HBV) replication cycle, but the function of HBx has been elusive until recently.
Christine M. Livingston, Dhivya Ramakrishnan, Michel Strubin, Simon P. Fletcher, Rudolf K. Beran   +4 more
doaj   +1 more source

HBx integration in diffuse large B-cell lymphoma inhibits Caspase-3-PARP related apoptosis

Tumour Virus Research
Diffuse large B-cell lymphoma (DLBCL) is the most common pathological type of non-Hodgkin lymphoma, and is closely associated with hepatitis B virus (HBV) infection status and hepatitis B X (HBx) gene integration.
Yanchun Wang, Xiaolin Guan, Fangfang Lv, Yi Rong, Xin Meng, Ying Tong, Xiaolu Ma, Hui Zheng, Cuncun Chen, Suhong Xie, Heng Zhang, Feng Dong, Lin Guo, Renquan Lu   +13 more
doaj   +1 more source

Hepatitis B virus X protein drives multiple cross-talk cascade loops involving NF-κB, 5-LOX, OPN and Capn4 to promote cell migration. [PDF]

PLoS ONE, 2012
Hepatitis B virus X protein (HBx) plays an important role in the development of hepatocellular carcinoma (HCC). However, the mechanism remains unclear.
Xuan Zhang, Xiaona You, Qi Wang, Tao Zhang, Yumei Du, Na Lv, Zhao Zhang, Shuai Zhang, Changliang Shan, Lihong Ye, Xiaodong Zhang   +10 more
doaj   +1 more source

The Malaysian Society of Gastroenterology and Hepatology Consensus Statements on Prevention and Early Detection of Hepatocellular Carcinoma in Malaysia

Journal of Gastroenterology and Hepatology, Volume 41, Issue 9, Page 2639-2655, September 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer‐related deaths in Malaysia. Early detection increases the likelihood of curative treatment and improves survival. This consensus document aims to provide evidence‐based, locally relevant recommendations for the prevention and early detection of HCC.
Su Yin Lau, Victoria Sinq‐Ling Kok, Soek‐Siam Tan, Syuhada Dan Adnan, Wei‐Lin Ng, Ban‐Hong Ang, Nur Yazmin Yaacob, Yeong Yeh Lee, Senamjit Kaur, Rosmawati Mohamed, Ping‐Foo Wong, Lee‐Ling Lim, Mohana Letchumanan, Shireene Ratna Vethakkan, Nurain Mohd Noor, Siow‐Foon Tan, Tiong‐Lim Low, Lee‐Boon Kiew, Wah‐Kheong Chan   +18 more
wiley   +1 more source

Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation [PDF]

Journal of Virology, 1995
Hepatitis B virus is a major risk factor in human hepatocellular carcinomas. We have used protein affinity chromatography to show that the 17-kDa hepatitis B virus gene product, HBx, binds directly to the human tumor suppressor gene product, p53. Interaction of HBx with p53 did not prevent p53 from specifically binding DNA.
R, Truant, J, Antunovic, J, Greenblatt, C, Prives, J A, Cromlish   +4 more
openaire   +2 more sources

HBx and c-MYC Cooperate to Induce URI1 Expression in HBV-Related Hepatocellular Carcinoma [PDF]

Unconventional prefoldin RNA polymerase II subunit 5 interactor (URI1) has emerged as an oncogenic driver in hepatocellular carcinoma (HCC). Although the hepatitis B virus (HBV) represents the most common etiology of HCC worldwide, it is unknown whether ...
40790374, 00403402, フジワラ, ヨシユキ, ツチヤ, ヒロユキ, Honjo, Soichiro, 40314330, 70263457, ホンジョウ, ソウイチロウ, Fujiwara, Yoshiyuki, 377, アミサキ, マサタカ, 100000247, 100001755, 100000303, 26772, 土谷, 博之, Shiota, Goshi, 4866, 95, 網崎, 正孝, Takenaga, Ai, シオタ, ゴウシ, 汐田, 剛史, 本城, 総一郎, 藤原, 義之, 780, 100001720, 3368, Tsuchiya, Hiroyuki, Amisaki, Masataka   +29 more
core   +1 more source

Dietary Terpenoids in Advancing Biofilm‐Mediated Cancer Prevention: Antibiofilm Cascade, Molecular Crosstalk, and Nano‐Facilitated Functional Delivery

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT The role of microbes in cancer is gaining attention these days, especially in the context of tumor‐associated biofilms and dysbiotic microbiota. Biofilm‐producing microorganisms, such as Fusobacterium nucleatum and Helicobacter pylori, trigger oncogenic inflammation and immune evasion in tumor initiation and progression, and in the development
Saikat Mazumder, Aditi Dey, Debasmita Bhattacharya, Dibyajit Lahiri, Moupriya Nag, Sudhriti Maity, Navin Kumar, Soumya Pandit, Vaseem Raja, Shubham Sharma, Shashi Prakash Dwivedi, Mithul Rajeev, Juwita Ratna Dewi, Lola Sanayeva, Dilbar Azimova   +14 more
wiley   +1 more source