Results 81 to 90 of about 9,710 (220)

HBx disturbs insulin signaling in hepatic cells.

, 2013
(A) The effect of HBx on the insulin-induced phosphorylation of the p85 subunit of PI3K and Akt in the dose-response manner. Control and HBx-expressed stable cells were incubated in the presence of insulin for 60 minutes.
JaeHun Cheong (366273), KyeongJin Kim (366271), Kook Hwan Kim (366272)   +2 more
core   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, Volume 13, Issue 39, 13 July 2026.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

HBx mutant-regulated RPL13AP25 mediates suboptimal virological response to entecavir and HCC progression

Cancer Cell International
Background A number of effective antiviral agents for chronic hepatitis B are available worldwide, and these agents have exhibited satisfactory virologic suppression, but suboptimal responses still occur in some patients.
Yang-Hsiang Lin, Ming-Wei Lai, Yu-De Chu, Kwang-Huei Lin, Chao-Wei Hsu, Rong-Nan Chien, Po-Heng Chuang, Chih-Lang Lin, Chau-Ting Yeh   +8 more
doaj   +1 more source

Hepatitis B virus X protein induces expression changes of miR-21, miR-22, miR-122, miR-132, and miR-222 in Huh-7 cell line [PDF]

Archives of Razi Institute
Background: Hepatocellular carcinoma (HCC) is recognized as one of the most deadly malignant cancers which ranks third among all annual cancer mortality rates. The hepatitis B virus (HBV) X protein (HBX) is known to play a key role in HCC.
Mahla Khosravi, Emad Behboudi, Hadi Razavi-Nikoo, Alijan Tabarraei   +3 more
doaj   +1 more source

Hepatitis B Doubly Spliced Protein (HBDSP) Promotes Epithelial‐Mesenchymal Transition, Migration, and Invasion via SP1/ETS1‐Dependent YAP Activation in Hepatoma Cells

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Chronic hepatitis B virus (HBV) infection remains a significant global health burden. Although the canonical HBV proteins are well‐studied, the pathological roles of HBV spliced variants and their encoded proteins are poorly understood. In this study, we investigate the cancer‐promoting potential of hepatitis B doubly spliced protein (HBDSP ...
Xiazhen Xu, Yibin Peng, Yuxin Ping, Tiantian Shao, Qiong Wu, Lu Zhang, Xu Lin, Changxi Yu, Wannan Chen   +8 more
wiley   +1 more source

Inhibition of Protease Activated Receptor 2 Attenuates HBx-Induced Inflammation and Mitochondria Oxidative Stress

Infection and Drug Resistance, 2022
Bin Li,1 Yonggang Li,2 Shuhua Li,1 Hongwei Li,1 Ling Liu,1 Yao Xu3 1Laboratory of Immunology and Pathogenic Biology, Experimental Teaching Center of Basic Medicine, Jinzhou Medical University, Jinzhou City, Liaoning Province, 121001, People’s Republic of
Li B, Li Y, Li S, Li H, Liu L, Xu Y
doaj  

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Hemoglobin Lepore‐Boston‐Washington: A Rare Cause of Unmeasurable HbA1c and Diagnostic Challenge in Diabetes

Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.
Filippo Russo, Silvia Trombetti, Maria Rosaria Storino, Raffaele Sessa, Carmela De Felice, Giuseppe Schiavone, Michela Grosso   +6 more
wiley   +1 more source

Molecular and Clinical Characterization of the Hb Tübingen [β106(G8) Leu→ Gln, HBB: c.320 T>A] Associated With Congenital Methemoglobinemia in a Chinese Family

Journal of Clinical Laboratory Analysis, Volume 40, Issue 8, April 2026.
ABSTRACT Background Congenital methemoglobinemia caused by hemoglobin variants is a rare hematological disorder often misdiagnosed due to overlapping features with enzymatic defects. Hb Tübingen, a β‐globin chain variant (βCD106), is characterized by increased autoxidation, heat instability, and cyanosis.
Hualei Luo, Zhenmin Ren, Yuhua Ye, Reem Nabil Hassan, Xiaoying Fu, Tao Wu, Yunsheng Chen, Xufeng Luo   +7 more
wiley   +1 more source

Effects of Hepatitis B Virus X Protein (HBx) on Cell-Growth Inhibition in a CCL13-HBx Stable Cell Line

Intervirology, 2008
<i>Objective:</i> The known function of hepatitis B virus X protein (HBx) is to determine the fate of cells by modulating various signaling pathways. In our previous study, we demonstrated that HBx inhibits tumor formation in nude mice injected with CCL13-HBx stable cell lines; however, the mechanism underlying this inhibition is unclear ...
Chan-Yen, Kuo, Jing-Chyi, Wang, Cheng-Chung, Wu, Shih-Lan, Hsu, Guang-Yuh, Hwang   +4 more
openaire   +2 more sources