Results 91 to 100 of about 9,710 (220)
Effect of HBx on the proliferation.
, 2014 HBx protein was over-expressed in both Huh 7 and Hep G2 cells (A). HBx was over-expressed in hepatoma cells and the empty vector was used as transfection control. Lane 1, Control; lane 2, Empty vector; and lane 3, HBx transfected cells.
Ekta Gupta (535573) +7 more
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Journal of Hepatocellular Carcinoma, 2022 Cuifang Zhang,1,2 Ying Xie,3 Ruixue Lai,1 Jianhua Wu,4 Zhanjun Guo1 1Department of Rheumatology and Immunology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China; 2Department of Oncology, The Pingshan County People’
Zhang C, Xie Y, Lai R, Wu J, Guo Z
doaj
Viruses, 2013 The role of hepatitis B virus (HBV) X protein (HBx) in the regulation of HBV replication remains controversial. In the present study, the role of HBx in regulating HBV replication was initially investigated in both HepG2 and Huh7 in vitro cell lines with
Xing Cheng +5 more
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MedComm, Volume 7, Issue 3, March 2026.Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia +4 more
wiley +1 more source
NF-κB signaling and crosstalk during carcinogenesis
4 open, 2019 Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex.
Brücher Björn L.D.M. +2 more
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STAT3 activation is associated with HBx-induced SOCS3 expression.
, 2013 (A) The activation of STAT3 via HBx-induced tyrosine phosphorylation. Proteins in liver extracts from control and HBx-transgenic mice were immunoblotted with anti-STAT3 and anti-phospho-STAT3 (Tyr705) antibodies.
JaeHun Cheong (366273) +2 more
core +1 more source
Intracellular localization of the hepatitis B virus HBx protein
Journal of General Virology, 2001 The hepatitis B virus (HBV) X protein (HBx) was originally suggested to be a viral transcriptional activator, but its functional mechanisms are still unclear. In this study we have analysed the intracellular localization of HBx in transfected cells and demonstrate that its compartmentalization is dependent on overall expression levels.
Frank, Henkler +6 more
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Inhibition of HBV-induced angiogenesis by ibuprofen: Role of HBx
Interventional Medicine and Applied Science, 2012 AbstractChronic hepatitis B virus (HBV) carriers may develop hepatocellular carcinoma (HCC) by a wide range of mechanisms including angiogenesis. We show that HBV replication induces the expression of angiogenic proteins interleukin 6 (IL6) and cyclooxygenase-2 (Cox2).
Zhang, Jianhua, Chen, William Wei Ning
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HBx inhibits CYP2E1 expression via downregulation of HNF4α.
, 2014 (A) HBV virus downregulated HNF4α and CYP2E1. HepG2215 cells, a cell line with the HBV genome integrated into the chromosome of HepG2 cells and capable of producing all HBV proteins, was used. Expression of HBx, CYP2E1 and HNF4α levels were measured with
Xiaodong Wang (66801) +6 more
core +1 more source
HBx and the Smc5/6 restriction factor
, 2020 Despite the availability of a vaccine, chronic hepatitis B virus (HBV) infection remains a leading cause of cirrhosis and liver cancer. The genome of HBV persists as an extrachromosomal DNA circle in infected cells. The family of Hepadnaviridae includes mammalian and avian hepatitis B viruses.
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