Results 101 to 110 of about 9,710 (220)
The hepatitis B virus HBx protein inhibits caspase 3 activity
, 1998 The hepatitis B virus-encoded HBx protein coactivates transcription of viral and cellular genes, and it is believed to play an important role in hepatitis B virus-related liver cancer.
Katrin Gottlob +7 more
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, 2013 (A) p22-FLIP synergistically enhances HBx-mediated NF-κB signaling in the context of HBV full genome. Relative NF-κB activity (left panel) was measured at 48 hours post-transfection of pNF-κB-Luc(0.25μg) and the indicated plasmids (0.4μg) in Huh7 cells ...
Kyun-Hwan Kim (9450) +7 more
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MicroRNA profiling of human hepatocytes induced by HBx in hepatocarcinogenesis. [PDF]
, 2009 Yip, Wing Kit.Thesis (M.Phil.)--Chinese University of Hong Kong, 2009.Includes bibliographical references (leaves 100-119).Abstract also in Chinese.Abstract (English version) --- p.iAbstract (Chinese version) --- p.iiiAcknowledgments --- p.vTable of ...
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Parvulin 14 and Parvulin 17 Bind to HBx and cccDNA and Upregulate Hepatitis B Virus Replication from cccDNA to Virion in an HBx-Dependent Manner [PDF]
, 2019 The parvulin 14 (Par14) and parvulin 17 (Par17) proteins, which are both encoded by the PIN4 gene, play roles in protein folding, chromatin remodeling, DNA binding, ribosome biogenesis, and cell cycle progression.
Kim, J +8 more
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Hepatitis B virus X gene inhibits hepatocyte apoptosis in mice via Akt/mTOR pathway
Di-san junyi daxue xuebao, 2019 Objective To investigate the effect of hepatitis B virus X (HBx) on apoptosis and cell cycle of hepatocytes in mice with normal immune functions and explore the underlying mechanisms.
WANG Xue +5 more
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Hepatitis B virus X protein accelerates the development of hepatoma
Cancer Biology & Medicine, 2014 The chronic infection of hepatitis B virus (HBV) is closely related to the occurrence and development of hepatocellular carcinoma (HCC). Accumulated evidence has shown that HBV X protein (HBx protein) is a multifunctional regulator with a crucial role in
Xiao-Dong Zhang, Yuan Wang, Li-Hong Ye
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Non-proteolytic ubiquitination of HBx controls HBV replication
Virologica Sinica• The expression level of TRIM21 in patients is negatively correlated with the replication and integration of HBV. • TRIM21 was found to trigger non-proteolytic ubiquitination of X protein of HBV. • This study proposes that the PRYSPRY and RING domains in TRIM21 dimer can form a docking conformation for HBx binding. • TRIM21-mediated HBx ubiquitination
Sheng, Xiangpeng +15 more
openaire +2 more sources
The Influence of HBx on Cellular Ca2+ Homeostasis
, 2017 慢性B型肝炎病毒(HBV)感染是造成肝細胞癌的主因，但是我們尚未完全解明HBV引發肝細胞癌的機制。科學家發現HBV產生的HBx可以透過調控細胞內的鈣離子，促進HBV的複製，並造成細胞死亡。科學家還發現HBx轉基因鼠容易得到肝癌，由此研究推論HBx是引發肝細胞癌的重要原因。於是我們研究HBx究竟如何調控細胞內鈣離子訊號，且藉此推敲HBx引發肝細胞癌的機制。我們透過拍攝HepG2和Huh7兩種肝癌細胞的活細胞鈣離子螢光影像進行觀察與分析。透過分析細胞質鈣離子指示劑fura-2訊號 ...
Tsai, Pei-Ju, 蔡沛儒
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Global re‐wiring of p53 transcription regulation by the hepatitis B virus X protein
Molecular Oncology, 2016 Background The tumour suppressor p53 is a central player in transcription regulation and cell fate determination. By interacting with p53 and altering its sequence‐specific binding to the response elements, the hepatitis B virus X protein (HBx) was ...
Cheryl Chan +6 more
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HBx protein induces gp96 expression.
, 2013 (A) Real-time PCR and western blot analysis of gp96 mRNA and protein levels in Huh7 cells transfected with the HBV expression vector pHBV or a GFP expression vector pEGFP-C1 (mock) or the empty vector pcDNA3.1 as a control.
Fusheng Wang (102710) +7 more
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