Results 1 to 10 of about 138,235 (114)

Hepatitis B virus X protein and hepatitis C virus core protein cooperate to repress E-cadherin expression via DNA methylation [PDF]

Heliyon, 2022
Dual infection of hepatitis B virus (HBV) and hepatitis C virus (HCV) is closely associated with an increased risk of hepatocellular carcinoma; however, the underlying mechanism is poorly understood. In the present study, we found that HBV X protein (HBx)
Hyunyoung Yoon, Kyung Lib Jang
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Hepatitis B Virus X Protein Stimulates Hepatitis C Virus (HCV) Replication by Protecting HCV Core Protein from E6AP-Mediated Proteasomal Degradation [PDF]

Microbiology Spectrum, 2022
Most clinical and experimental studies have suggested that hepatitis C virus (HCV) is dominant over hepatitis B virus (HBV) during coinfection, although the underlying mechanism remains unclear.
Hyunyoung Yoon, Jiwoo Han, Kyung Lib Jang   +2 more
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Inactivation of tumor suppressor TAp63 by hepatitis B virus X protein in hepatocellular carcinoma [PDF]

Chinese Medical Journal, 2022
. Background:. The hepatitis B virus X (HBx) protein plays a critical role in the initiation and progression of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC).
Bangxiang Xie, Qian Hao, Xiang Zhou, Dexi Chen, Yuanyuan Ji   +4 more
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Hepatitis B virus X protein and TGF-β: partners in the carcinogenic journey of hepatocellular carcinoma [PDF]

Frontiers in Oncology
Hepatitis B infection is substantially associated with the development of liver cancer globally, with the prevalence of hepatocellular carcinoma (HCC) cases exceeding 50%.
Wei Yan, Wei Yan, Wei Yan, Dean Rao, Dean Rao, Dean Rao, Feimu Fan, Feimu Fan, Feimu Fan, Huifang Liang, Huifang Liang, Huifang Liang, Huifang Liang, Zunyi Zhang, Zunyi Zhang, Zunyi Zhang, Hanhua Dong, Hanhua Dong, Hanhua Dong   +18 more
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Hepatitis B Virus X Protein Upregulates SREBP2 to Modulate Autophagy in Hepatocellular Carcinoma [PDF]

Cancer Medicine
Background The interaction between Hepatitis B virus X protein (HBx) and sterol regulatory element binding protein 2 (SREBP2) in modulating autophagy to influence inflammation and tumorigenesis is not fully understood.
Qiuyan Lin, Yongxu Lin, Yongzhu Huang, Mingrong Wang, Xiaoxia Xie, Weiqi Cai, Qilan Guo, Pingying Jiang, Yuanlin Qi, Dan Li   +9 more
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Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction [PDF]

Nature Communications, 2019
Hepatitis B virus X protein (HBx) binds anti-apoptotic Bcl-xL through its BH3-like motif to promote viral replication. Here, the authors provide the structure of the HBx BH3-like domain and Bcl-xL, which shows an unusual mode of interaction, and identify
Tian-Ying Zhang, Hong-Ying Chen, Jia-Li Cao, Hua-Long Xiong, Xiao-Bing Mo, Tian-Liang Li, Xiao-Zhen Kang, Jing-Hua Zhao, Bo Yin, Xiang Zhao, Cheng-Hao Huang, Quan Yuan, Ding Xue, Ning-Shao Xia, Y. Adam Yuan   +14 more
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Modern views on the role of X gene of the hepatitis B virus (Hepadnaviridae: Orthohepadnavirus: Hepatitis B virus) in the pathogenesis of the infection it causes

Вопросы вирусологии, 2022
The review presents information on the role of hepatitis B virus (Hepadnaviridae: Orthohepadnavirus: Hepatitis B virus) (HBV) X gene and the protein it encodes (X protein) in the pathogenesis of viral hepatitis B.
Y. V. Panasiuk, N. V. Vlasenko, N. S. Churilova, V. V. Klushkina, D. V. Dubodelov, E. N. Kudryavtseva, M. I. Korabelnikova, Z. S. Rodionova, T. A. Semenenko, S. N. Kuzin, V. G. Akimkin   +10 more
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Mechanism of HBx Protein Inhibiting DKK4 Expression and Its Effect on Proliferation and Migration of Hepatocarcinoma Cell Lines

Zhongliu Fangzhi Yanjiu, 2022
Objective To explore the mechanism of hepatitis B virus X protein down-regulating DKK4 and its effect on the proliferation, migration of HCC cell lines.
ZHANG Wenjing, ZHANG Gufen, WANG Xiaoyan, ZHANG Ying, QUAN Huiqin   +4 more
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Role of hepatitis B virus non-structural protein HBx on HBV replication, interferon signaling, and hepatocarcinogenesis

Frontiers in Microbiology, 2023
Hepatitis B, a global health concern caused by the hepatitis B virus (HBV), infects nearly 2 billion individuals worldwide, as reported by the World Health Organization (WHO).
Fei Wang, Hongxiao Song, Fengchao Xu, Jing Xu, Le Wang, Fan Yang, Yujia Zhu, Guangyun Tan   +7 more
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Pre- and Post-Transcriptional Control of HBV Gene Expression: The Road Traveled towards the New Paradigm of HBx, Its Isoforms, and Their Diverse Functions

Biomedicines, 2023
Hepatitis B virus (HBV) is an enveloped DNA human virus belonging to the Hepadnaviridae family. Perhaps its main distinguishable characteristic is the replication of its genome through a reverse transcription process. The HBV circular genome encodes only
Rodrigo A. Villanueva, Alejandra Loyola
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