Results 1 to 10 of about 18,512 (153)

Developing a strain-dependent susceptibility to hepatocellular carcinoma in a murine model based on histopathological evidence and genetic context. [PDF]

Animal Model Exp Med
Using F1 (C57BL/6J/Smad4+/− X CC) mice, we found that partial loss of Smad4 promotes liver carcinogenesis in a strain‐dependent manner, highlighting the importance of genetic modifiers in tumor susceptibility. The use of Collaborative Cross mice provides a valuable platform for uncovering genotype‐specific cancer susceptibilities in preclinical ...
Zohud O, Nashef A, Abu-Elnaaj I, Iraqi FA.   +3 more
europepmc   +2 more sources

Omics-Based Identification of Shared and Gender Disparity Routes in Hras12V-Induced Hepatocarcinogenesis: An Important Role for Dlk1-Dio3 Genomic Imprinting Region

Frontiers in Genetics, 2021
The phenomenon of gender disparity is very profound in hepatocellular carcinoma (HCC). Although previous research has revealed important roles of microRNA (miRNA) in HCC, there are no studies investigating the role of miRNAs in gender disparity observed ...
Jing Zhang, Huiling Li, Jianyi Dong, Nan Zhang, Yang Liu, Xiaoqin Luo, Jun Chen, Jingyu Wang, Aiguo Wang   +8 more
doaj   +1 more source

The dual role of transforming growth factor-beta signatures in human B viral multistep hepatocarcinogenesis: early and late responsive genes [PDF]

Journal of Liver Cancer, 2022
Background/Aim Transforming growth factor-beta (TGF-β) has a dichotomous role, functioning as a tumor suppressor and tumor promoter. TGF-β signatures, explored in mouse hepatocytes, have been reported to predict the clinical outcomes of hepatocellular ...
Jeong Eun Yoo, Ji Hae Nahm, Young-Joo Kim, Youngsic Jeon, Young Nyun Park   +4 more
doaj   +1 more source

The Effects and Underlying Mechanisms of Hepatitis B Virus X Gene Mutants on the Development of Hepatocellular Carcinoma

Frontiers in Oncology, 2022
We aimed to elucidate the mechanism by which hepatitis B virus X (HBx) mutations increase the occurrence of hepatocellular carcinoma (HCC) and identify novel putative therapeutic targets. Wild-type HBx (WT-HBx) and four HBx mutants (M1, A1762T/G1764A; M2,
Rui Pu, Wenbin Liu, Xinyu Zhou, Xi Chen, Xiaomei Hou, Shiliang Cai, Liping Chen, Jianfeng Wu, Fan Yang, Xiaojie Tan, Jianhua Yin, Xin Wang, Guangwen Cao   +12 more
doaj   +1 more source

Serum Anti-14-3-3 Zeta Autoantibody as a Biomarker for Predicting Hepatocarcinogenesis

Frontiers in Oncology, 2021
Hepatocellular carcinoma (HCC) is a common malignancy worldwide. Alpha-fetoprotein (AFP) is still the only serum biomarker widely used in clinical settings.
Ting Wang, Xue-ying Huang, Su-jun Zheng, Ye-ying Liu, Si-si Chen, Feng Ren, Jun Lu, Zhong-ping Duan, Mei Liu   +8 more
doaj   +1 more source

JMJD4-demethylated RIG-I prevents hepatic steatosis and carcinogenesis

Journal of Hematology & Oncology, 2022
Background Hepatocarcinogenesis is driven by necroinflammation or metabolic disorders, and the underlying mechanisms remain largely elusive. We previously found that retinoic acid-inducible gene-I (RIG-I), a sensor for recognizing RNA virus in innate ...
Zhenyang Li, Ye Zhou, Kaiwei Jia, Yingyun Yang, Liyuan Zhang, Suyuan Wang, Yue Dong, Mu Wang, Yunhui Li, Shan Lu, Wannian Zhang, Luxin Zhang, Yiwen Fan, Dingji Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +17 more
doaj   +1 more source

Expression Levels of Three Key Genes CCNB1, CDC20, and CENPF in HCC Are Associated With Antitumor Immunity

Frontiers in Oncology, 2021
IntroductionHepatocellular carcinoma (HCC) is the most common primary liver cancer with a low 5-year survival rate. The heterogeneity of HCC makes monotherapy unlikely.
Tengfei Si, Zhenlin Huang, Yuanhang Jiang, Abigail Walker-Jacobs, Shaqira Gill, Robert Hegarty, Mohammad Hamza, Shirin Elizabeth Khorsandi, Shirin Elizabeth Khorsandi, Shirin Elizabeth Khorsandi, Wayel Jassem, Wayel Jassem, Nigel Heaton, Nigel Heaton, Yun Ma   +14 more
doaj   +1 more source

Hormonally Induced Hepatocellular Carcinoma in Diabetic Wild Type and Carbohydrate Responsive Element Binding Protein Knockout Mice

Cells, 2021
Objective: In the rat, the pancreatic islet transplantation model is an established method to induce hepatocellular carcinomas (HCC), due to insulin-mediated metabolic and molecular alterations like increased glycolysis and de novo lipogenesis and the ...
Vincent Nuernberger, Sharif Mortoga, Christoph Metzendorf, Christian Burkert, Katrina Ehricke, Elisa Knuth, Jenny Zimmer, Stephan Singer, Neetika Nath, Majedul Karim, Mohd Yasser, Diego F. Calvisi, Frank Dombrowski, Silvia Ribback   +13 more
doaj   +1 more source

Cancer chemopreventive potential of cooked glutinous purple rice on the early stages of hepatocarcinogenesis in rats

Frontiers in Nutrition, 2022
Cancer prevention using dietary phytochemicals holds great potential, particularly in the alternative treatment of liver cancer. Our previous study found that the methanol extract of cooked purple rice performed various biological functions including ...
Huina Guo, Huina Guo, Charatda Punvittayagul, Arpamas Vachiraarunwong, Warunyoo Phannasorn, Rawiwan Wongpoomchai   +5 more
doaj   +1 more source

Histopathological and clinicopathological studies on the antioxidant effect of gold nanoparticles in diethyInitrosamine induced hepatocarcinogenesis in rats [PDF]

Veterinary Medical Journal - Giza, 2016
This study investigated the antioxidant and therapeutic effect of gold nanoparticles (GNPs) against diethylnitrosamine (DENA) induced hepatocarcinogenesis. 24 rats were divided into four groups.
Eman Hassanen, Reda Korany, Taher Salah Eldin, A Bakeer   +3 more
doaj   +1 more source