HBV HBx protein masks epigenetic reader Spindlin1 via an inter-molecular zinc finger to subvert transcriptional control [PDF]
Nature CommunicationsThe HBx protein from Hepatitis B virus (HBV) is essential for replication and promotes pathogenicity during chronic infection. HBx hijacks host proteins, reprogramming them to evade antiviral defence.
Alexis Clavier +8 more
doaj +2 more sources
HBx Downregulates TFEB via the CUL4A/CUL4B–DDB1 Axis to Disrupt Lysosomal Function in Hepatocellular Carcinoma Cells [PDF]
CellsHepatitis B virus (HBV) infection remains a major global health burden, with chronic infection leading to severe liver diseases including cirrhosis and hepatocellular carcinoma (HCC). HBV-encoded X protein (HBx) plays a critical role in viral replication
Chunyan Zhang, Yuanping Han, Huan Yang
doaj +2 more sources
PreS1BP mediates inhibition of Hepatitis B virus replication by promoting HBx protein degradation [PDF]
Virus ResearchBackground: PreS1-binding protein (PreS1BP), recognized as a nucleolar protein and tumor suppressor, influences the replication of various viruses, including vesicular stomatitis virus (VSV) and herpes simplex virus type 1 (HSV-1).
Jun Wang +10 more
doaj +2 more sources
HBx Induces the Production of N-GPC3 in Hepatoma Cells to Promote the Evasion of Macrophage Phagocytosis Through Activating Furin. [PDF]
J Cell Mol MedABSTRACT The hepatitis B virus X protein (HBx) is a central oncogenic driver in hepatocellular carcinoma (HCC). Although glypican‐3 (GPC3) is a phosphatidylinositol proteoglycan‐specific biomarker for HCC. However, the combined role of HBx and GPC3 in mediating HCC cell evasion from macrophage phagocytosis remains unclear. Here, we demonstrate that HBx
Wu J +8 more
europepmc +2 more sources
Homeobox protein MSX-1 restricts hepatitis B virus by promoting ubiquitin-independent proteasomal degradation of HBx protein. [PDF]
PLoS PathogensHepatitis B virus (HBV) X protein (HBx) is a key factor for regulating viral transcription and replication. We recently characterized homeobox protein MSX-1 (MSX1) as a host restriction factor that inhibits HBV gene expression and genome replication by ...
Qian Qiu +15 more
doaj +2 more sources
Antiviral Compounds Screening Targeting HBx Protein of the Hepatitis B Virus [PDF]
International Journal of Molecular Sciences, 2022 Tetsuhiro Chiba +2 more
exaly +2 more sources
HBx Promotes Liver Cancer Cells to Escape NK-92 Cell Attack by Mediating ADAM10 to Enzyme Cut MICA/B Shedding From Cancer Cell Membrane. [PDF]
J Cell Mol MedABSTRACT MICA/B shedding from the membrane of cancer cells can inhibit natural killer (NK) cells from attacking hepatocellular carcinoma (HCC). This study explored the role of HBx in mediating MICA/B shedding. The expression of HBx, MICA/B and HIF‐1α in HBV‐infected HCC was analysed using bioinformatics, and the localization of these proteins in ...
Huang K +8 more
europepmc +2 more sources
The Role of HBx Protein in Diseases Beyond the Liver [PDF]
Infection and Drug Resistance, 2023 Yize Li, Hong-Mei Zhang, Qing-Qing Liu
exaly +2 more sources
Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex [PDF]
Cells, 2020 Joseph M Hyser +2 more
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Transcriptomic identification of HBx-associated hub genes in hepatocellular carcinoma [PDF]
PeerJ, 2021 Background Hepatocellular carcinoma (HCC) is one of the most common malignancies around the world. Among the risk factors involved in liver carcinogenesis, hepatitis B virus (HBV) X protein (HBx) is considered to be a key regulator in ...
Zhengzhong Ni +8 more
doaj +2 more sources