Results 11 to 20 of about 3,362,872 (199)

Hepatitis B Viral Protein HBx: Roles in Viral Replication and Hepatocarcinogenesis

Viruses
Hepatitis B virus (HBV) infection remains a major public health concern worldwide, with approximately 296 million individuals chronically infected. The HBV-encoded X protein (HBx) is a regulatory protein of 17 kDa, reportedly responsible for a broad ...
Dong Li, Yassir Hamadalnil, Thomas Tu
doaj   +4 more sources

Chromatin remodelling factor BAF155 protects hepatitis B virus X protein (HBx) from ubiquitin-independent proteasomal degradation

Emerging Microbes and Infections, 2019
HBx is a short-lived protein whose rapid turnover is mainly regulated by ubiquitin-dependent proteasomal degradation pathways. Our prior work identified BAF155 to be one of the HBx binding partners.
Huijing Chen, Yi Zhang, Shuangshuang Ye, Qiong Wu, Youfen Lin, Kaiqin Sheng, Wannan Chen, Xinjian Lin, Xu Lin   +8 more
doaj   +3 more sources

The hepatitis B virus HBx protein inhibits caspase 3 activity [PDF]

Journal of Biological Chemistry, 1998
The hepatitis B virus-encoded HBx protein coactivates transcription of viral and cellular genes, and it is believed to play an important role in hepatitis B virus-related liver cancer.
Katrin Gottlob, LEVRERO, Massimo, K. Gottlob, Massimo Levrero, Marcilla Fulco, A. Graessmann, M. Fulco, Adolf Graessmann   +7 more
core   +6 more sources

Id-1 Induces Proteasome-dependent Degradation of the HBX Protein

Journal of Molecular Biology, 2008
Id-1 is a member of the HLH protein family that regulates a wide range of cellular processes such as cell proliferation, apoptosis, senescence and overexpression of Id-1 was recently suggested to play roles in the development and progression of different
Wang, X, Wong, YC, Lee, TKW, Chiu, Yung-Tuen, Chiu, YT, Ling, MT, Wong, KF, Leung, SCL, Wang, Xiang-Hong, Leung, Steve, Ling, Patrick, Lee, Terence, Fung, Maggie, Wong, Yong Chuan, Fung, MKL, Wong, Kwong Fai   +15 more
core   +5 more sources

Epigenetic control of HBV by HBx protein-releasing the break?

Nature Reviews Gastroenterology & Hepatology, 2015
HBV persists by depositing covalently closed circular DNA (cccDNA) into the nucleus of infected host cells. HBV X protein (HBx) is a crucial determinant for regulating HBV activity, but the molecular details have not been fully understood. A new role for
Protzer, U., Ulrike Protzer, Protzer, Ulrike   +2 more
core   +3 more sources

Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice [PDF]

Virology, 2009
Identifying the requirements for the regulatory HBx protein in hepatitis B virus (HBV) replication is an important goal. A plasmid-based HBV replication assay was used to evaluate whether HBx subcellular localization influences its ability to promote ...
Hodgson, Amanda J., Keasler, Victor V., Slagle, Betty L., Madden, Charles R.   +3 more
core   +3 more sources

The Role of Hepatitis B Viral Protein HBx in Hepatocarcinogenesis

Dokkyo Medical Journal
With approximately 296 million individuals estimated worldwide, the chronic infection of hepatitis B virus (HBV) is one of the most common risk factors for hepatocellular carcinoma (HCC).
Muroyama, Ryosuke
core   +4 more sources

Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: an alternative mechanism of HBx-related pathogenesis [PDF]

Proceedings of the National Academy of Sciences, 2002
The role of the hepatitis B virus X protein (HBx) in the pathogenesis of hepatitis B virus (HBV) infection remains unclear. HBx exhibits pleiotropic biological effects, whose in vivo relevance is a matter for debate. In the present report, we have used a
Bréchot, C, Tralhao, JG, Tu, H, Roudier, J, Goulenok, C, Joulin, V, Kremsdorf, D, Carnot, F, Morosan, S, Zavala, F, Giannini, C   +10 more
core   +6 more sources

JMJD2D stabilises and cooperates with HBx protein to promote HBV transcription and replication. [PDF]

JHEP Rep, 2023
HBV infection is a global health burden. Covalently closed circular DNA (cccDNA) transcriptional regulation is a major cause of poor cure rates of chronic hepatitis B (CHB) infection. Herein, we evaluated whether targeting host factors to achieve functional silencing of cccDNA may represent a novel strategy for the treatment of HBV infection.To ...
Kong X, Liu Z, Zhang R, Xie F, Liang R, Zhang Y, Yu L, Yang W, Li X, Chen Q, Li B, Hong Y, Li M, Xia X, Gu L, Fu L, Li X, Shen Y, Wu T, Yu C, Li W.   +20 more
europepmc   +4 more sources

Novel HBx-interacting host cellular factors regulate dynamic nuclear and cytoplasmic localization of Hepatitis B virus X protein (HBx)

Virology
The hepatitis B virus (HBV) X protein (HBx) is a key player in viral transcription, replication, and HBV-associated hepatocarcinogenesis. Several novel HBx-interacting host cellular factors: DDX1, DDX3, MOV10 RNA helicases, INI1/hSNF5 chromatin ...
Ariumi, Yasuo
core   +2 more sources