Tracking Virus-Specific CD4+ T Cells during and after Acute Hepatitis C Virus Infection [PDF]
Background. CD4+ T cell help is critical in maintaining antiviral immune responses and such help has been shown to be sustained in acute resolving hepatitis C.
Paul Klenerman +175 more
core +2 more sources
Sero-prevalence and risk factors for hepatitis B virus infection among health care workers in a tertiary hospital in Uganda. [PDF]
BACKGROUND: Hepatitis B virus (HBV) infection is a global public health challenge. Prevalence of current hepatitis B virus infection in the general population in Uganda is about 10%.
Bwogi, Josephine +14 more
core +2 more sources
Characterisation of the membrane and protein interactions of the Hepatitis C Virus NS2 [PDF]
Hepatitis C virus (HCV) readily establishes a chronic infection and it is currently thought to infect 2-3% of the global population. Treatment for HCV places a severe burden on patients, leading to a premature treatment termination in approximately 20 ...
King, Barnabas James
core +6 more sources
Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection [PDF]
Cellular immune responses are an important correlate of hepatitis C virus (HCV) infection outcome. These responses are governed by the host's human leukocyte antigen (HLA) type, and HLA-restricted viral escape mutants are a critical aspect of this host ...
Cheng, Wendy +70 more
core +1 more source
Hepatitis B virus (HBV) X protein (HBx) is a viral regulatory and multifunctional protein. It is well-known that the canonical HBx reading frame bears two phylogenetically conserved internal in-frame translational initiation codons at Met2 and Met3, thus
Sergio Hernández +5 more
doaj +1 more source
Human immunodeficiency virus : 25 years of diagnostic and therapeutic strategies and their impact on hepatitis B and C virus [PDF]
The human immunodeficiency virus (HIV) had spread unrecognized in the human population as sexually transmitted disease and was finally identified by its disease AIDS in 1981.
Hans Wilhelm Doerr +5 more
core +1 more source
Liver X receptor mediates hepatitis B virus X protein–induced lipogenesis in hepatitis B virus–associated hepatocellular carcinoma # [PDF]
Abstract Although hepatitis B virus X protein (HBx) has been implicated in abnormal lipid metabolism in hepatitis B virus (HBV)–associated hepatic steatosis, its underlying molecular mechanism remains unclear. Liver X receptor (LXR) plays an important role in regulating the expression of genes involved in hepatic lipogenesis ...
Tae-Young, Na +9 more
openaire +2 more sources
Hepatitis B Virus-X Downregulates Expression of Selenium Binding Protein 1
Selenium binding protein 1 (SELENBP1) has been known to be reduced in various types cancer, and epigenetic change is shown to be likely to account for the reduction of SELNEBP1 expression. With cDNA microarray comparative analysis, we found that SELENBP1
Young-Man Lee +3 more
doaj +1 more source
Geographic and species association of hepatitis B virus genotypes in non-human primates [PDF]
Infection with hepatitis B virus (HBV) has been detected in human populations throughout the world, as well as in a number of ape species (Pan troglodytes, Gorilla gorilla, gibbons [Nomascus and Hylobates species] and Pongo pygmaeus).
Holmes, E.C +8 more
core +1 more source
Identifying and Characterizing Interplay between Hepatitis B Virus X Protein and Smc5/6
Hepatitis B X protein (HBx) plays an essential role in the hepatitis B virus (HBV) replication cycle, but the function of HBx has been elusive until recently.
Christine M. Livingston +4 more
doaj +1 more source

