Results 111 to 120 of about 9,710 (220)
Zhongshan Daxue xuebao. Yixue kexue ban, 2000 【目的】构建携 HBx 基因的逆转录病毒载体, 为研究 HBx 基因与肝癌生物学行为间的关系提供基础。【方法】采 用 PCR 技术从 HBV 全基因组中扩增 HBx 基因; 将 HBx 基因亚克隆至质粒 pLNSX, 构建质粒 pLNSHBx,磷酸钙-DNA 共沉淀 法将重组体导入包装细胞系 PA317, 检测培养上清病毒滴度。【结果】应用 PCR 技术成功地从 HBV 基因组中克隆出全长 HBx 基因, 并经序列分析证实; 建立了产病毒细胞株 PA317/HBx,检测其培养上清病毒滴度为 8.
闵 军, 刘彦文, 陈积圣
doaj
SIGNIFICANCE OF ANTI-HBX ANTIBODIES IN HEPATITIS-B VIRUS-INFECTION
, 1991 Serological responses to hepatitis B virus-X determinants have been noted in human sera, but conflicting findings concerning the correlation of anti-HBx antibodies with different stages of hepatitis B virus infection or pathological sequelae have been ...
LEVRERO M +13 more
core +2 more sources
Transcriptional regulation of tumor suppressor gene RASSF1A by HBx
Molecular and Cellular ProbesThe occurrence of liver cancer in China is primarily attributed to chronic hepatitis B virus (HBV) infection. HBV X protein (HBx) has emerged as a significant carcinogenic driver in HBV-related liver cancer. However, the underlying mechanism by which HBx contributes to liver cancer development is not fully understood.This study investigated HBx's role ...
Yanhong Kang +4 more
openaire +3 more sources
Additional file 1: Figure S1. of Genome-wide identification of direct HBx genomic targets
, 2017 HBx ChIP-Seq experiments analysis. Figure S2. HBx occupancy on cellular promoters. Figure S3. HBx occupancy on the control RFP2 promoter. Figure S4. HBx occupancy on cellular promoters in NTCP-HepG2 cells infected with wild-type and mt-HBx HBV. Figure S5.
Daniel DâAndrea (4227907) +10 more
core +1 more source
Multiple mechanisms of HBx in promoting chromosome instability
, 2017 The hepatitis B virus X protein (HBx) encoded in HBV genome has been implicated in development of hepatocellular carcinoma (HCC) by promoting centrosome aberration and chromosomal instability.
Ching, YP
core
Sequences of chemically synthesized HBx-siRNAs.
, 2013 Sequences of chemically synthesized HBx-siRNAs.
Cai Zhang (163340) +3 more
core +1 more source
Virology JournalBackground Chronic hepatitis B virus (HBV) infection remains a serious public health challenge, and primary treatment strategies are unable to cure HBV infection due to the persistence of HBV covalently closed circular DNA (cccDNA) in the nuclei of cells.
Linshan Jiang +9 more
doaj +1 more source
HBx promotes tumorigenicity through RRM2-mediated autophagy in hepatocellular carcinoma
Background Hepatitis B virus (HBV) infection can exacerbate liver disease progression through multiple mechanisms, eventually leading to hepatocellular carcinoma (HCC).
Yaqun Li +6 more
core +1 more source
HBx, p22-FLIP and NEMO potentially form a ternary complex.
, 2013 (A) Interaction of HBx with p22-FLIP in Huh7 cells. After co-transfection of HBx-HA and p22-FLIP plasmids in Huh7 cells (approximately 6×105), cell lysates were immunoprecipitated by anti-Flip (left panel) or anti-HA (right panel) antibodies ...
Kyun-Hwan Kim (9450) +7 more
core +1 more source
The hepatitis B virus (HBV) X protein (HBx) is a key player in viral transcription, replication, and HBV-associated hepatocarcinogenesis. Several novel HBx-interacting host cellular factors: DDX1, DDX3, MOV10 RNA helicases, INI1/hSNF5 chromatin ...
Ariumi, Yasuo
core