Results 51 to 60 of about 9,710 (220)
Episomal HBV persistence within transcribed host nuclear chromatin compartments involves HBx
Epigenetics & Chromatin, 2018 Background In hepatocyte nuclei, hepatitis B virus (HBV) genomes occur episomally as covalently closed circular DNA (cccDNA). The HBV X protein (HBx) is required to initiate and maintain HBV replication.
Kai O. Hensel +4 more
doaj +1 more source
Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux +6 more
wiley +1 more source
HBx, especially HBx-d382, enhances CyclinD1 expression.
, 2012 (A) CyclinD1 protein level of the engineered LO2 cells. (B) The histogram of CyclinD1 mRNA and protein level in LO2/HBx and LO2/HBx-d382 cells, compared with LO2/pcDNA3.0 cells ...
Zhouhua Hou (142578) +6 more
core +1 more source
Hepatitis B virus X protein upregulates mTOR signaling through IKKβ to increase cell proliferation and VEGF production in hepatocellular carcinoma. [PDF]
PLoS ONE, 2012 Hepatocellular carcinoma (HCC), a major cause of cancer-related death in Southeast Asia, is frequently associated with hepatitis B virus (HBV) infection.
Chia-Jui Yen +9 more
doaj +1 more source
Advanced Science, Volume 13, Issue 50, 7 September 2026.This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu +6 more
wiley +1 more source
HBx decreases IRS1 expression.
, 2013 (A) The effects of HBx protein on IRS1 expression in wild-type and HBx-transgenic mice. Proteins in liver extracts from control and HBx-transgenic mice were immunoblotted with anti-IRS1, anti-phospho-IRS1 (Ser307), anti-IRβ, anti-HBx, and anti-Actin ...
JaeHun Cheong (366273) +2 more
core +1 more source
Advanced Science, Volume 13, Issue 51, 14 September 2026.Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang +10 more
wiley +1 more source
, 2016 (A) The expression of HBx in Huh-7 cells transfected with HBV expressing plasmid (WT HBV) or plasmid expressing HBV genome with HBx mutation (MUT HBV) was measured by western blot analysis. β-actin was used as a loading control. (B-C) ROS levels in Huh-7
Ai-Long Huang (3181887) +8 more
core +1 more source
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT Ferroptosis is a form of programmed cell death characterized by iron‐dependent phospholipid peroxidation and is implicated in a wide range of human diseases. Emerging evidence highlights the critical role of epigenetic regulation in this process.
Xiaoqian Tang +5 more
wiley +1 more source
Hepatitis B Virus HBx Gene and Hepatocarcinogenesis
Intervirology, 1995 The association between hepatitis B virus (HBV) and hepatocellular carcinoma (HCC) has been known over the past 20 years. We have shown that the HBx gene of HBV induces HCC in transgenic mice and that HBx protein may be involved in hepatocarcinogenesis in human chronic HBV infection.
openaire +2 more sources