Results 21 to 30 of about 9,710 (220)
The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway. [PDF]
, 1998 The X gene product of the human hepatitis B virus (HBx) is a transcriptional activator of various viral and cellular genes. We recently have determined that the production of tumor necrosis factor-alpha (TNF-alpha) by HBV-infected hepatocytes is ...
Armesilla, Angel +11 more
core +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: The hepatitis B virus X protein (HBx) is a viral trans-activator that plays a crucial role in pathogenesis of hepatocellular carcinoma (HCC) via an unknown mechanism.
Mashael R. Al-Anazi +4 more
doaj +1 more source
Carboxyl-terminal truncated HBx regulates a distinct microRNA transcription program in hepatocellular carcinoma development. [PDF]
PLoS ONE, 2011 BACKGROUND: The biological pathways and functional properties by which misexpressed microRNAs (miRNAs) contribute to liver carcinogenesis have been intensively investigated.
Wing-Kit Yip +16 more
doaj +1 more source
Hayati Journal of Biosciences, 2022 Hepatitis B virus (HBV) infects human and causes chronic liver infection, leading to liver cirrhosis and hepatocellular carcinoma. HBV X (Hbx) protein is known to interact with tumor suppressor protein p53 and block its translocation into the nucleus ...
Anita Artarini +4 more
doaj +1 more source
Emerging Microbes and Infections, 2019 HBx is a short-lived protein whose rapid turnover is mainly regulated by ubiquitin-dependent proteasomal degradation pathways. Our prior work identified BAF155 to be one of the HBx binding partners.
Huijing Chen +8 more
doaj +1 more source
Biomedicines, 2021 Hepatitis B virus (HBV) X protein (HBx) is a viral regulatory and multifunctional protein. It is well-known that the canonical HBx reading frame bears two phylogenetically conserved internal in-frame translational initiation codons at Met2 and Met3, thus
Sergio Hernández +5 more
doaj +1 more source
Journal of General Virology, 2009 HBx, a small regulatory protein of hepatitis B virus, plays an important role in stimulating viral genome replication. HBx was shown to be associated with diverse subcellular locations, such as the nucleus, cytoplasm and mitochondria. Some studies have linked the stimulation of genome replication by HBx to its cytoplasmic function, while other reports ...
Man-Young, Cha +4 more
openaire +2 more sources
Hepatitis B Virus Protein X Induces Degradation of Talin-1
Viruses, 2016 In the infected human hepatocyte, expression of the hepatitis B virus (HBV) accessory protein X (HBx) is essential to maintain viral replication in vivo.
Maarten A. A. van de Klundert +3 more
doaj +1 more source
Molecules, 2021 Hepatitis B virus (HBV) is a circular, and partially double-stranded DNA virus. Upon infection, the viral genome is translocated into the cell nucleus, generating the covalently closed circular DNA (cccDNA) intermediate, and forming a mini chromosome ...
Cristian Prieto +7 more
doaj +1 more source
HBx Inhibits the Growth of CCL13-HBX-Stable Cells via the GSK-3β/β-Catenin Cascade
Intervirology, 2008 <i>Objective:</i> The hepatitis B virus X protein (HBx) plays critical roles in cell survival via modulation of signaling pathways. In our previous studies, we reported that HBx inhibited the growth of CCL13-HBx-stable cells (Chang-HBx cells) in vitro and tumor formation in vivo in CCL13-HBx-cell-injected nude mice; however, this inhibition
Chan-Yen, Kuo +3 more
openaire +2 more sources