Results 111 to 120 of about 6,841 (192)

cccDNA– induced hepatocarcinogenesis is regulated by an HBx–stimulated interaction between male specific lethal 2 and cccDNA [PDF]

HPB, 2019
Xueli Jin, Suk kyun Hong, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh   +4 more
openaire   +1 more source

Association between intrahepatic cccDNA and the severity of liver inflammation in chronic hepatitis B virus infection patients

Frontiers in Medicine
Background and aimsThis research aimed to examine the association between hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and liver inflammation in chronic hepatitis B (CHB) infection patients.MethodsFrom August 2013 to June 2022, CHB ...
Suxian Zhao, Chen Dong, Chudi Chang, Jiaming Zhang, Jing Li, Xiaoxiao Zhang, Weiguang Ren, Ying Zhang, Yuemin Nan   +8 more
doaj   +1 more source

SIRT7 Promotes Hepatitis B Virus Transcription via the Upregulation of DDB1 Expression and Facilitation of DDB1 Recruitment to Covalently Closed Circular DNA

Frontiers in Bioscience-Landmark
Background: Transcription of the hepatitis B virus (HBV) is regulated by the acetylation status of H3/H4 histones bound to the covalently closed circular DNA (cccDNA) minichromosome.
Fang Cao, Yuemei Zhao, Shouhui Zhong, Lina Chen, Xing-Yue Wang, Anqi Zheng, Jiwei Zuo, Mingjun Wu, Qiao Cheng, Kai-Fu Tang   +9 more
doaj   +1 more source

HOXA‐AS2 Epigenetically Inhibits HBV Transcription by Recruiting the MTA1‐HDAC1/2 Deacetylase Complex to cccDNA Minichromosome

Advanced Science
Persistent transcription of HBV covalently closed circular DNA (cccDNA) is critical for chronic HBV infection. Silencing cccDNA transcription through epigenetic mechanisms offers an effective strategy to control HBV.
YiPing Qin, JiHua Ren, HaiBo Yu, Xin He, ShengTao Cheng, WeiXian Chen, Zhen Yang, FengMing Sun, ChunDuo Wang, SiYu Yuan, Peng Chen, DaiQing Wu, Fang Ren, AiLong Huang, Juan Chen   +14 more
doaj   +1 more source

HBV cccDNA: The Stumbling Block for Treatment of HBV Infection [PDF]

Journal of Clinical and Translational Hepatology, 2019
Liu, Shousheng, Xin, Yongning
openaire   +2 more sources

Aiming at the cccDNA for a cure of HBV persistence [PDF]

Chinese Science Bulletin, 2019
openaire   +1 more source

CS7.3 cccDNA function and HBV replication

International Journal of Infectious Diseases, 2011
Levrero, M., Belloni, L., Guerrieri, F., Pediconi, N.   +3 more
openaire   +1 more source

Dual HBV cccDNA-linked HiBiT reporter hepatocyte models for screening of candidate cccDNA modulators. [PDF]

Virulence
Cao J, Zhang Y, Ma J, Wang S, Wu Y, Xiong H, Wang M, Shi T, Fu B, Fu X, Chen X, Ye H, Xia N, Yuan Q.   +13 more
europepmc   +1 more source

Targeting cccDNA for Degradation: Endogenous- and Exogenous-Based Methods of Nuclear-Localized DNA Destruction in the Context of Chronic Hepatitis B Infection. [PDF]

Viruses
Thompson C, Meier-Stephenson V.
europepmc   +1 more source

HBsAg glycan isomer: a potential circulating biomarker for monitoring cccDNA and predicting virologic response in chronic hepatitis B. [PDF]

Front Cell Infect Microbiol
Li J, Hu Z, Wu M, Ji Y, Zhang X, Chen F, Wu X, Zhang Q, Chen C, Zhu C, Zhu L.   +10 more
europepmc   +1 more source