Results 41 to 50 of about 6,841 (192)

Overexpression of DNA-methyltransferases in persistency of cccDNA pool in chronic hepatitis B [PDF]

Терапевтический архив, 2017
Aim. To define the role of DNA-methyltransferases of type 1 and type 3A in hepatitis B viral cycle. Materials and methods. Human hepatoma cells HepG2 with stable expression of 1.1-mer HBV genome were transfected with vectors encoding DNA ...
D S Kostyushev, A P Zueva, S A Brezgin, A D Lipatnikov, V N Simirskii, D Glebe, E V Volchkova, G A Shipulin, V P Chulanov   +8 more
doaj   +1 more source

The role of host DNA ligases in hepadnavirus covalently closed circular DNA formation. [PDF]

PLoS Pathogens, 2017
Hepadnavirus covalently closed circular (ccc) DNA is the bona fide viral transcription template, which plays a pivotal role in viral infection and persistence.
Quanxin Long, Ran Yan, Jieli Hu, Dawei Cai, Bidisha Mitra, Elena S Kim, Alexander Marchetti, Hu Zhang, Soujuan Wang, Yuanjie Liu, Ailong Huang, Haitao Guo   +11 more
doaj   +1 more source

Host factors involved in HBV cccDNA maintenance [PDF]

, 2017
B型肝炎ウイルス（HBV）持続感染者は国内で130～150万人と推定されており、感染を放置すれば慢性肝炎、肝硬変、肝がんへと進行するおそれがある。HBV持続感染では、cccDNAと呼ばれる環状ウイルスDNAが、宿主細胞の核内に維持されウイルス複製の鋳型となる。cccDNAを除去する有効な治療法は無く、B型肝炎の根治が難しい理由となっているが、現在のところcccDNAを標的とする分子機構の知見が少ない。本研究では、HBV cccDNAに対してゲノム情報を改変すると考えられる宿主因子AID ...
70378892, 喜多村, 晃一, 449
core   +1 more source

IFN-α confers epigenetic regulation of HBV cccDNA minichromosome by modulating GCN5-mediated succinylation of histone H3K79 to clear HBV cccDNA [PDF]

Clinical Epigenetics, 2020
AbstractBackgroundHepatitis B virus covalently closed circular DNA (HBV cccDNA) is assembled by histones and non-histones into a chromatin-like cccDNA minichromosome in the nucleus. The cellular histone acetyltransferase GCN5, displaying succinyltransferase activity, is recruited onto cccDNA to modulate HBV transcription in cells.
Ying Yuan, Hongfeng Yuan, Guang Yang, Haolin Yun, Man Zhao, Zixian Liu, Lina Zhao, Yu Geng, Lei Liu, Jiapei Wang, Huihui Zhang, Yufei Wang, Xiao-dong Zhang   +12 more
openaire   +2 more sources

Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA.

PLoS Pathogens, 2022
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), serving as the viral persistence form and transcription template of HBV infection, hijacks host histone and non-histone proteins to form a minichromosome and utilizes posttranslational ...
Elena S Kim, Jun Zhou, Hu Zhang, Alexander Marchetti, Maarten van de Klundert, Dawei Cai, Xiaoyang Yu, Bidisha Mitra, Yuanjie Liu, Mu Wang, Ulrike Protzer, Haitao Guo   +11 more
doaj   +1 more source

Potential capacity of interferon-α to eliminate covalently closed circular DNA (cccDNA) in hepatocytes infected with hepatitis B virus

Gut Pathogens, 2021
Interferon-alpha (IFN-α) and nucleot(s)ide analogs (NAs) are first-line drugs for the treatment of chronic hepatitis B virus (HBV) infections. Generally, NAs target the reverse transcription of HBV pregenomic RNA, but they cannot eliminate covalently ...
Gang Wang, Jun Guan, Nazif U. Khan, Guojun Li, Junwei Shao, Qihui Zhou, Lichen Xu, Chunhong Huang, Jingwen Deng, Haihong Zhu, Zhi Chen   +10 more
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Image_2_KAT2A Promotes Hepatitis B Virus Transcription and Replication Through Epigenetic Regulation of cccDNA Minichromosome.TIF

, 2022
Hepatitis B virus (HBV) infection remains a major health problem worldwide. Sufficient maintenance of the HBV covalently closed circular DNA (cccDNA), which serves as a template for HBV transcription, is responsible for the failure of antiviral therapies.
Ji-Hua Ren (3181890), Fan Li (49953), Si-Yu Yuan (11991191), Xu Wen (2708356), Mei-Ling Dong (11991200), Jing Liu (38537), Yuan Zhang (41832), Min-Li Yang (11991197), Hai-Bo Yu (2406934), Yu-Jiao Zhou (11991194), Da-Peng Zhang (802906), Fang Ren (819350), Juan Chen (61123), Hui Zhang (7197), Ai-Long Huang (3181887), Qing Wang (27728), Yi-Ping Qin (8132244), Zhen Yang (107412), Yao Chen (149006), Sheng-Tao Cheng (4110184), Hong-Zhong Zhou (3181878), Ming Tan (34506), Wei-Xian Chen (540311), Xin He (48101), Zhi-Hong Li (1523968)   +24 more
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Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA [PDF]

Science, 2014
Clearance of Chronic Virus The family of mRNA-editing enzymes, APOBEC, restricts hepatitis B virus (HBV) replication. Lucifora et al. (p.
Lucifora, Julie, Xia, Yuchen, Reisinger, Florian, Zhang, K., Stadler, Daniela, Cheng, Xiaoming, Sprinzl, Martin, Koppensteiner, Herwig, Makowska, Zuzanna, Volz, Tassilo, Remouchamps, Caroline, Chou, Wen-Min, Thasler, Wolfgang, Huser, Norbert, Durantel, David, Liang, T Jake, Munk, Carsten, Heim, Markus, Browning, Jeffrey, Dejardin, Emmanuel, Dandri, Maura, Schindler, Michael, Heikenwalder, Mathias, Protzer, Ulrike   +23 more
openaire   +5 more sources

cccDNA Maintenance in Chronic Hepatitis B – Targeting the Matrix of Viral Replication

Infection and Drug Resistance, 2020
Maura Dandri,1,2 Joerg Petersen3 1Department of Internal Medicine, University Medical Center Hamburg – Eppendorf, Hamburg, Germany; 2German Center for Infection Research (DZIF), Hamburg-Luebeck-Borstel-Riems Site, Germany; 3Institute for ...
Dandri M, Petersen J
doaj  

Schematic model of IL6 modulation of cccDNA transcription.

, 2016
STAT3, HNF1α and HNF4α bind the cccDNA and contribute to activate the transcription of cccDNA (middle). IL6 treatment results in the hypo-acetylation of cccDNA-bound histones and inhibits HBV transcription through the combined effect on HNF1α and HNF4α ...
Debora Salerno (446879), Natalia Pediconi (828493), Cecilia Scisciani (828492), Gianna Aurora Palumbo (828491), Leonardo Lupacchini (828494), Dulce Alfalate (828495), Massimo Levrero (17645), Silvia Di Cocco (828497), Francesca Guerrieri (828496), Ludovica Calvo (259889), Laura Belloni (828498)   +10 more
core   +1 more source