Results 21 to 30 of about 6,841 (192)

Functionally cured chronic hepatitis B: A cure‐related occult HBV infection state [PDF]

mLife, Volume 5, Issue 4, Page 393-400, August 2026.
Abstract Occult HBV infection (OBI) is characterized by the presence of replication‐competent hepatitis B virus (HBV) DNA (covalently closed circular DNA [cccDNA] and/or relaxed circular DNA [rcDNA]) in the liver and/or HBV DNA in the blood, despite negative hepatitis B surface antigen (HBsAg) serology.
Fengmin Lu, Xin Zheng, Xinyu Du, Xianlin Ye, Yongzhen Liu, Jinfeng Zeng, Ying Yan   +6 more
wiley   +2 more sources

Regulation Mechanism of HBV cccDNA

Infection International, 2012
Covalently closed circular (ccc) DNA of hepatitis B virus (HBV) existed in the nuclei of HBV infected hepatocytes with a half-life time of 14.3 years in a mathematic model.
Min Li, Shun-ai Liu, Jun Cheng, Min Quan, Qi Wang   +4 more
core   +2 more sources

Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes. [PDF]

PLoS Pathogens, 2013
Covalently closed circular DNA (cccDNA) of hepadnaviruses exists as an episomal minichromosome in the nucleus of infected hepatocyte and serves as the transcriptional template for viral mRNA synthesis. Elimination of cccDNA is the prerequisite for either
Fei Liu, Matthew Campagna, Yonghe Qi, Xuesen Zhao, Fang Guo, Chunxiao Xu, Sichen Li, Wenhui Li, Timothy M Block, Jinhong Chang, Ju-Tao Guo   +10 more
doaj   +2 more sources

Generation of HBV cccDNA using single-stranded M13 phage DNA for authentic minichromosome functionality [PDF]

Journal of Virology
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) persists as minichromosomes in the nuclei of hepatocytes and serves as the transcriptional template for viral RNAs.
Yumeng Li, Ting Hua, Menghan Hao, Liman Chen, Wenjun Huang, Zhong Fang, Asha Ashuo, Yaming Li, Zhigang Yi, Hongzhou Gu, Zhenghong Yuan, Jieliang Chen   +11 more
doaj   +2 more sources

Super-Resolution Microscopy Analysis of Hepatitis B Viral cccDNA and Host Factors

Viruses, 2023
Infection with hepatitis B virus (HBV) cannot be cured completely because of the persistence of covalently closed circular DNA (cccDNA). We previously found that the host gene dedicator of cytokinesis 11 (DOCK11) was required for HBV persistence. In this
Phuong Thi Bich Doan, Kouki Nio, Tetsuro Shimakami, Kazuyuki Kuroki, Ying-Yi Li, Saiho Sugimoto, Hideo Takayama, Hikari Okada, Shuichi Kaneko, Masao Honda, Taro Yamashita   +10 more
doaj   +2 more sources

Therapeutic interventions aimed at cccDNA: unveiling mechanisms and evaluating the potency of natural products [PDF]

Frontiers in Cellular and Infection Microbiology
Hepatitis B virus (HBV) infection persists as a formidable global health predicament, imposing a substantial burden on public health. It not only elevates the risk of cirrhosis but also significantly heightens the incidence of hepatocellular carcinoma ...
Liyuan Hao, Liyuan Hao, Shenghao Li, Xiaoyu Hu   +3 more
doaj   +2 more sources

IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome. [PDF]

PLoS ONE, 2015
The HBV covalently closed circular DNA (cccDNA) is organized as a mini-chromosome in the nuclei of infected hepatocytes by histone and non-histone proteins.
Gianna Aurora Palumbo, Cecilia Scisciani, Natalia Pediconi, Leonardo Lupacchini, Dulce Alfalate, Francesca Guerrieri, Ludovica Calvo, Debora Salerno, Silvia Di Cocco, Massimo Levrero, Laura Belloni   +10 more
doaj   +4 more sources

Nucleotide excision repair and poly(ADP-ribose) polymerase 1 cooperate in HBV cccDNA synthesis: A potential viral therapeutic target [PDF]

JHEP Reports
Background & Aims: Blocking the synthesis of HBV covalently closed circular (ccc)DNA is crucial for achieving a viral cure. Previous work showed that inhibiting nucleotide excision repair (NER) reduced cccDNA levels in HBV-producing liver cells. Here,
Hsu-Chin Hung, Hung-Wen Tsai, Yung-Tsung Li, Wen-Chun Liu, Kuang-Hsiung Cheng, Chia-Jui Yen, Yun-Ping Lee, Yuan-Hsin Fang, Cheng-Hsiang Chuang, Hui-Lin Wu, Ting-Tsung Chang, Wenya Huang   +11 more
doaj   +2 more sources

Detection and characterization of Hepatitis B virus double-stranded linear DNA-derived covalently closed circular DNA in chronic hepatitis B patients. [PDF]

PLoS Pathogens
Background and aimsHepatitis B virus (HBV) replication generates a double-stranded linear DNA (dslDNA) byproduct. This dslDNA can undergo intermolecular and intramolecular nonhomologous end-joining (NHEJ) recombination, resulting in viral integration and
Hsin-Ni Liu, Elena Kim, Ning Sun, Zhili Wang, ThiThuyTu Nguyen, Fwu-Shan Shieh, Yuanjie Liu, Marc G Ghany, Raymond T Chung, Richard K Sterling, Selena Y Lin, Haitao Guo, Daryl T Y Lau, Ying-Hsiu Su   +13 more
doaj   +2 more sources

DOCK11 promotes HBV cccDNA formation through a PARP1-dependent mechanism [PDF]

Microbiology Spectrum
Hepatitis B virus (HBV) infection remains a major global health concern due to the persistence of covalently closed circular DNA (cccDNA) in the hepatocyte nucleus, which contributes to viral persistence and hepatocarcinogenesis despite antiviral therapy.
Hideo Takayama, Kouki Nio, Kazuyuki Kuroki, Ying-Yi Li, Saiho Sugimoto, Tetsuro Shimakami, Kazuhisa Murai, Kazunori Kawaguchi, Takumi Nishiuchi, Shuichi Kaneko, Masao Honda, Taro Yamashita   +11 more
doaj   +2 more sources