Results 11 to 20 of about 6,841 (192)

hnRNPA2B1 induces HBV cccDNA degradation by recruiting APOBEC3B. [PDF]

Nucleic Acids Res
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) constitutes a viral persistence reservoir that sustains chronic infection. Although the DNA damage response (DDR) facilitates cccDNA biogenesis, its role in regulating cccDNA stability ...
Fu Z, Wang L, Sun Y, Ren C, Dou Y, Wang K, Fan Y, Yue X, Li C, Gao L, Liang X, Ma C, Wu Z.   +12 more
europepmc   +5 more sources

Minicircle HBV cccDNA with a Gaussia luciferase reporter for investigating HBV cccDNA biology and developing cccDNA-targeting drugs [PDF]

Scientific Reports, 2016
Chronic Hepatitis B Virus (HBV) infection is generally not curable with current anti-viral drugs. Virus rebounds after stopping treatment from the stable HBV covalently-closed-circular DNA (cccDNA). The development of drugs that directly target cccDNA is
Reszka-Blanco, Natalia J., Hu, Jianming, Wu, Yaxu, Murphy, Christopher M., Li, Feng, Su, Lishan, Chi, Liqun, Cheng, Liang   +7 more
core   +3 more sources

Establishment of Cre-mediated HBV recombinant cccDNA (rcccDNA) cell line for cccDNA biology and antiviral screening assays [PDF]

Antiviral Research, 2018
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), existing in hepatocyte nuclei as a stable minichromosome, plays a central role in the life cycle of the virus and permits the persistence of infection.
Wu, Min, Lu Bai, Yue, Lei, Xiaonan Zhang, Chen, Jieliang, Zhang, Xiaonan; id_orcid, Li, Yaming, Jin Li, Yaming Li, Zhenghong Yuan, Min Wu, Lei Yue, Bai, Lu, Li, Jin, Jieliang Chen, Yuan, Zhenghong   +15 more
core   +3 more sources

Mapping the Interactions of HBV cccDNA with Host Factors [PDF]

International Journal of Molecular Sciences, 2019
Hepatitis B virus (HBV) infection is a major health problem affecting about 300 million people globally. Although successful administration of a prophylactic vaccine has reduced new infections, a cure for chronic hepatitis B (CHB) is still unavailable ...
Yee-Joo Tan, Zijie Lim, Nur K. Mohd-Ismail, Jayantha Gunaratne   +3 more
core   +3 more sources

Gene Editing Technologies to Target HBV cccDNA

Viruses, 2022
Hepatitis B virus (HBV) remains a significant cause of mortality and morbidity worldwide, since chronic HBV infection is associated with elevated risk of cirrhosis and hepatocellular carcinoma.
Gregoire, Francine, Testoni, Barbara, Martinez, Maria Guadalupe, Zoulim, Fabien, Elena Smekalova, Emmanuel Combe, Smekalova, Elena, Francine Gregoire, Maria Guadalupe Martinez, Fabien Zoulim, Barbara Testoni, Combe, Emmanuel   +11 more
core   +4 more sources

Analyses of HBV cccDNA quantification and modification.

, 2016
Covalently closed circular DNA (cccDNA) serves as the transcriptional template of hepatitis B virus (HBV) replication in the nucleus of infected cells. It ensures the persistence of HBV even if replication is blocked.
Protzer, U., Ulrike Protzer, Xia, Y., Stadler, D., Daniela Stadler, Yuchen Xia, Chunkyu Ko, Ko, C.   +7 more
core   +5 more sources

Targeting Viral cccDNA for Cure of Chronic Hepatitis B [PDF]

Current Hepatology Reports, 2020
Purpose of Review Chronic hepatitis B (CHB), caused by hepatitis B virus (HBV), is amajor cause of advanced liver disease and hepatocellular carcinoma (HCC) worldwide. HBV replication is characterized by the synthesis of covalently closed circular (ccc)
Eloi Verrier, Thomas F. Baumert, Ligat, Gaëtan, Verrier, Eloi, Ligat, G. (Gaëtan), Baumert, Thomas F., Goto, Kaku, Kaku Goto, Goto, K. (Kaku), Gaëtan Ligat, Verrier, E. (Eloi)   +10 more
core   +5 more sources

Estimating hepatitis B virus cccDNA persistence in chronic infection [PDF]

Virus Evolution, 2020
Hepatitis B virus (HBV) infection is a major global health problem with over 240 million infected individuals at risk of developing progressive liver disease and hepatocellular carcinoma.
Lumley, Sheila F, Pellis, Lorenzo; id_orcid, McKeating, Jane A., Mckeating, Jane A, Matthews, Philippa C, Lythgoe, Katrina, Lumley, Sheila F., Lumley, Sheila, Lythgoe, Katrina A, Matthews, Philippa, Matthews, Philippa C., Lythgoe, Katrina A., McKeating, Jane   +12 more
core   +4 more sources

A novel highly specific qPCR assay for distinguishing HBV cccDNA from rcDNA following bisulfite pretreatment [PDF]

Journal of Virology
The persistence of covalently closed circular DNA (cccDNA) underlies chronic hepatitis B virus (HBV) infection and remains as the major barrier to achieving a functional cure.
Ning Sun, Zhili Wang, Zach Heimer, Chris Wenner, Selena Y. Lin, Heidi Y. Ding, Roman Kubas, You-Yu Liu, Eliza Qiu, Hsin-Ni Liu, Hsu-Chin Hung, Wenya Huang, Tianlun Zhou, Daryl T.-Y. Lau, Ying-Hsiu Su, Haitao Guo   +15 more
doaj   +2 more sources

Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target

Gut, 2022
International audienceObjectives Chronic hepatitis B virus (HBV) infection is a leading cause of liver disease and hepatocellular carcinoma. A key feature of HBV replication is the synthesis of the covalently close circular (ccc)DNA, not targeted by ...
Pessaux, Patrick, Margaux J Heuschkel, Naoto Fujiwara, Miller, Julija, Mukherji, Atish, Root, David E., Doernbrack, Katharina, Laurent Mailly, Jühling, Frank, Verrier, Eloi R., Heuschkel, Margaux, J, Heydmann, Laura, Yujin Hoshida, Eloi R Verrier, El Saghire, Houssein, Katharina Doernbrack, Catherine Schuster, Michael Nassal, Gaëtan Ligat, Atish Mukherji, Frank Jühling, Sen-Yung Hsieh, Nassal, Michael, Dörnbrack, Katharina, Houssein El Saghire, David E Root, Ligat, Gaëtan, Brino, Laurent, Laurent Brino, Anne Maglott-Roth, Emanuele Felli, Hoshida, Yujin, Felli, Emanuele, Heuschkel, Margaux J, Hsieh, Sen-Yung, Patrick Pessaux, Julija Miller, Thomas F. Baumert, Laura Heydmann, Verrier, Eloi, Fujiwara, Naoto, Maglott-Roth, Anne, Root, David, Mailly, Laurent, Baumert, Thomas, Schuster, Catherine   +45 more
core   +4 more sources