Angewandte Chemie, EarlyView.A hybrid “confocal” electrochemiluminescence (ECL) microscopy combines depth‐resolved and time‐resolved imaging to visualize ECL processes across three spatial dimensions and time. By exploiting sluggish coreactant kinetics at ITO electrodes, homogeneous redox propagation enables depth‐resolved, single‐cell resolution mapping of living multicellular ...
Elisa D'Arrigo +4 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Same building blocks, different destinies. Pathway complexity directs nucleic acid–loaded polyion complex micelles along distinct assembly trajectories, resulting in either hexagonally shaped or spheroidal nanoparticles with distinct internal structuring.
Lennart van den Hoven +7 more
wiley +2 more sources
Viral manipulation of host cell glutamine metabolism and glutamine rewiring in hepatic diseases: Editorial on "Glutamate dehydrogenase 1-dependent α-ketoglutarate promotes hepatitis B virus transcription by modulating histone methylations on the covalently closed circular DNA minichromosome". [PDF]
Clin Mol HepatolDezhbord M, Kim KH.
europepmc +1 more source
Covalently closed circular DNA (cccDNA) forms a template for the replication of hepatitis B virus (HBV) and duck HBV (DHBV). Recent studies suggest that activation-induced cytidine deaminase (AID) functions in innate immunity, although its molecular ...
Chowdhury, Sajeda +4 more
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An allosteric inhibitor of sirtuin 2 blocks hepatitis B virus covalently closed circular DNA establishment and its transcriptional activity. [PDF]
Antiviral ResTang L +4 more
europepmc +1 more source
Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus covalently closed circular DNA. [PDF]
J Biol Chem, 2021 Meier-Stephenson V +9 more
europepmc +1 more source
Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy
Angewandte Chemie International Edition, EarlyView.Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean +3 more
wiley +1 more source
Interferon Alpha Induces Multiple Cellular Proteins That Coordinately Suppress Hepadnaviral Covalently Closed Circular DNA Transcription. [PDF]
J Virol, 2020 Cheng J +6 more
europepmc +1 more source
Quantification and epigenetic evaluation of the residual pool of hepatitis B covalently closed circular DNA in long-term nucleoside analogue-treated patients. [PDF]
Sci Rep, 2020 Lebossé F +9 more
europepmc +1 more source
Worldwide, an estimated 296 million people are chronically infected with hepatitis B virus (HBV). Chronic hepatitis B (CHB) is a known cause of life-threatening liver diseases including cirrhosis, fibrosis, and hepatocellular carcinoma (HCC).
Temple, Heidi
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