Results 231 to 240 of about 2,861,963 (268)
Differences in sequences between HBV relaxed circular and covalently closed circular DNA forms
Clinical and Experimental Hepatology, 2016 Rybicka, Magda +3 more
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Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles
European Journal of Organic Chemistry, EarlyView.Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu +2 more
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Journal of Virology, 2017 Hepatitis B virus (HBV) covalently closed circular (CCC) DNA functions as the only viral template capable of coding for all the viral RNA species and is thus essential to initiate and sustain viral replication.
Jianming Hu, Jun Luo
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Journal of Hepatology, 2006 Background/Aims: This study aimed to measure the intrahepatic total hepatitis B virus (HBV) DNA and covalently closed circular DNA (cccDNA) levels in tumor and non-tumor tissues in hepatocellular carcinoma (HCC) patients.
James Fung +2 more
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Surrogate Markers for Hepatitis B Virus Covalently Closed Circular DNA
Seminars in Liver Disease, 2022Chronic infection with the hepatitis B virus (HBV) is one of the most common causes of liver disease worldwide. Chronic HBV infection is currently incurable because of the persistence of the viral template for the viral transcripts, covalently closed circular deoxyribonucleic acid (cccDNA). Detecting changes in cccDNA transcriptional activity is key to
Thomas Tu +2 more
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Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA
Liver International, 2017 Background & Aims: Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a key to viral persistence in chronic hepatitis B infection. Serum hepatitis B core‐related antigen (HBcrAg) is a novel marker for HBV disease.
James Fung, Ka-Shing Cheung
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Quantitative binding of covalently closed circular DNA to nitrocellulose in NaI
Analytical Biochemistry, 1983A procedure for quantitatively binding covalently closed circular DNA to nitrocellulose is detailed. The procedure involves making DNA saturated with respect to Nat at 25 degrees C, denaturing the DNA by heating to 80-100 degrees C, then passing the DNA-NaI solution through a nitrocellulose membrane at 50-60 degrees C.
J, Bresser, D, Gillespie
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Melting behavior of a covalently closed, single-stranded, circular DNA
Biochemistry, 1989We synthesized the 26-residue deoxynucleotide sequence d(TTCCT5GGAATTCCT5GGAA) which folds intramolecularly to form a dumbbell-shaped, double-hairpin structure with a gap between the 3' and the 5' ends. We used T4 polynucleotide kinase to phosphorylate the 5' end followed by T4 DNA ligase to close the 3' and 5' ends.
D A, Erie +4 more
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In vitro packaging of covalently closed circular monomers of bacteriophage DNA
Journal of Molecular Biology, 1975Extracts from coliphage P2 or P4-infected cells can package exogenous P2 or P4 DNA into viable phage particles. This in vitro system was used to determine the structure of the DNA substrate for the packaging reaction. Results obtained with covalently joined linear concatemers, covalently closed circles, and mature phage DNA as the substrates indicate ...
G J, Pruss, J C, Wang, R, Calendar
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Interaction of covalently closed circular PM-2 DNA and hedamycin
Biochemical and Biophysical Research Communications, 1979Abstract The interaction of hedamycin with covalently closed circular PM-2 DNA was examined. Hedamycin produced strand breakage detectable in alkaline sucrose gradients. Under neutral conditions hedamycin inhibited ethidium bromide binding and induced conformational changes in PM-2 DNA.
S, Mong, J E, Strong, S T, Crooke
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