Results 61 to 70 of about 2,861,963 (268)

Cellular DNA Topoisomerases Are Required for the Synthesis of Hepatitis B Virus Covalently Closed Circular DNA [PDF]

Journal of Virology, 2019
Persistent HBV infection relies on stable maintenance and proper functioning of a nuclear episomal form of the viral genome called cccDNA, the most stable HBV replication intermediate. One of the major reasons for the failure of currently available antiviral therapeutics to cure chronic HBV infection is their inability to eradicate or ...
Muhammad, Sheraz, Junjun, Cheng, Liudi, Tang, Jinhong, Chang, Ju-Tao, Guo   +4 more
openaire   +2 more sources

PCR mediated recombination impacts the analysis of hepatitis B Virus covalently closed circular DNA [PDF]

, 2016
International audienceBackground: The replication of HBV involves the production of covalently closed circular DNA (cccDNA) from the HBV genome through the repair of virion relaxed circular DNA (rcDNA) in the virion.
Vartanian, Jean Pierre, Jean-Pierre Vartanian, Simon Wain-Hobson, Suspène, Rodolphe, Thiers, Valérie, Rodolphe Suspène, Wain-Hobson, Simon, Valérie Thiers   +7 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Covalently closed-circular hepatitis B virus DNA reduction with entecavir or lamivudine

World Journal of Gastroenterology, 2015
To investigate the reduction in hepatitis B virus (HBV) covalently closed-circular DNA (cccDNA) with entecavir (ETV) or lamivudine (LAM).This analysis included patients who had participated in the randomized Phase III study ETV-022 comparing ETV vs LAM in nucleos(t)ide-naive, HBeAg-positive patients.
Bowden, S, Locarnini, S, Chang, TT, Chao, YC, Han, KH, Gish, RG, de Man, Rob, Yu, M, Llamoso, C, Tang, Hui   +9 more
openaire   +2 more sources

Characterization of the Intracellular Deproteinized Relaxed Circular DNA of Hepatitis B Virus: an Intermediate of Covalently Closed Circular DNA Formation [PDF]

Journal of Virology, 2007
ABSTRACT Covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is formed by conversion of capsid-associated relaxed circular DNA (rcDNA) via unknown mechanisms and exists in the nucleus of the infected hepatocyte as a minichromosome that serves as the transcription template for viral RNAs. To study the molecular pathway of cccDNA
Haitao, Guo, Dong, Jiang, Tianlun, Zhou, Andrea, Cuconati, Timothy M, Block, Ju-Tao, Guo   +5 more
openaire   +2 more sources

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Disrupting HBV Persistence: Genetic Engineering Approach to Break the Oncogenic HBx Gene

NUST Journal of Engineering Sciences
Chronic Hepatitis B virus (HBV) infection can cause liver cirrhosis or cancer , making it a persistent worldwide health concern. Nucleoside analogs used in current antiviral treatments can prevent HBV from replicating, but they do not break the ...
Saleha Resham, Haiqa Khan, Fazal Adnan, Sobia Manzoor   +3 more
doaj   +1 more source

Uracil DNA glycosylase counteracts APOBEC3G-induced hypermutation of hepatitis B viral genomes: excision repair of covalently closed circular DNA. [PDF]

PLoS Pathogens, 2013
The covalently closed circular DNA (cccDNA) of the hepatitis B virus (HBV) plays an essential role in chronic hepatitis. The cellular repair system is proposed to convert cytoplasmic nucleocapsid (NC) DNA (partially double-stranded DNA) into cccDNA in ...
Kouichi Kitamura, Zhe Wang, Sajeda Chowdhury, Miyuki Simadu, Miki Koura, Masamichi Muramatsu   +5 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Does Tyrosyl DNA Phosphodiesterase-2 Play a Role in Hepatitis B Virus Genome Repair?

PLoS ONE, 2015
Hepatitis B virus (HBV) replication and persistence are sustained by a nuclear episome, the covalently closed circular (CCC) DNA, which serves as the transcriptional template for all viral RNAs.
Xiuji Cui, Rebecca McAllister, Rajeev Boregowda, Ji A Sohn, Felipe Cortes Ledesma, Keith W Caldecott, Christoph Seeger, Jianming Hu   +7 more
doaj   +1 more source