Results 131 to 140 of about 550,309 (325)

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

Advanced Science, EarlyView.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo, Lingyi Yang, Zirui Huang, Kai Qian, Yuan Shi, Mengjia Fei, Yuan Feng, Zixian Chen, Ming Qiu, Linglin Tang, Anqi Li, Zhibao Lv, Jiangbin Liu, Zhou Chen, Kuiran Dong, Zhuoying Wang   +15 more
wiley   +1 more source

Testing hypotheses under covariate-adaptive randomisation and additive models

Statistical Theory and Related Fields, 2018
Covariate-adaptive randomisation has a long history of applications in clinical trials. Shao, Yu, and Zhong [(2010). A theory for testing hypotheses under covariate-adaptive randomization. Biometrika, 97, 347–360] and Shao and Yu [(2013).
Ting Ye
doaj   +1 more source

A Simple Test for the Absence of Covariate Dependence in Hazard Regression Models [PDF]

This paper extends commonly used tests for equality of hazard rates in a two-sample or k-sample setup to a situation where the covariate under study is continuous.
Bhattacharjee, Arnab
core   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Covariates of Fear of Falling and Associated Activity Curtailment [PDF]

, 1998
Jonathan Howland, Margie E. Lachman, E. Wesley F. Peterson, Jennifer Cote, Linda Kasten, Alan M. Jette   +5 more
openalex   +1 more source

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
wiley   +1 more source

Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. [PDF]

, 1996
Richard E. Ostlund, JH Yang, Samuel Klein, Ronald L. Gingerich   +3 more
openalex   +1 more source

Type I Interferon Signaling Augments Autoimmunity in Neuromyelitis Optica Spectrum Disorder

Advanced Science, EarlyView.
The cGAS‐STING innate immune pathway is excessively activated both in peripheral monocytes and CNS microglia in patients with NMOSD, leading to an overproduction of IFN‐I. IFN‐I subsequently acts on AQP4‐specific autoreactive T cells. Blocking this pathway may offer novel therapeutic options for individuals with NMOSD.
Tian‐Xiang Zhang, Xiaoxiao Yang, Xue Gao, Xiaoshan Du, Xuegan Lian, Naiyuan Shao, Ye Liu, Zhenning Huang, Dongmei Jia, Alexander Y. L. Lau, Zhiguo Li, Zaal Kokaia, Fu‐Dong Shi, Chao Zhang   +13 more
wiley   +1 more source

Rural households vulnerability to covariate and idiosyncratic shocks using multilevel longitudinal model: evidence from Ethiopia

Heliyon, 2022
The economic reports on income inequality, poverty, and other welfare indicators are relevant if it was supported by the evidence of income traps because rural households in developing countries were frequently hit by several shocks.
Yalfal Temesgen, Mengistu Ketema, Alelign Ademe   +2 more
doaj  

Mixture models for cancer survival analysis: application to population‐based data with covariates [PDF]

, 1999
R. De Angelis, R. Capocaccia, T. Hakulinen, B. Soderman, A. Verdecchia   +4 more
openalex   +1 more source