NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis
Advanced Science, EarlyView.Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong +18 more
wiley +1 more source
Cytokine Storm Induction Linked to Multi‐Organ Failure in Fatal Jellyfish Stings
Advanced Science, EarlyView.N. nomurai is the most important injurious species in the coastal area of China. Model construction, omics analysis, mechanism exploration, and intervention measures of N. nomurai envenomation are performed in the current study, and it suggested that cytokine storm played an important role in pathogenesis.
Yichao Wang +15 more
wiley +1 more source
Letter to the editor: Comment on GLP-1-based drugs and COVID-19 treatment
, 2020 Tianru Jin, Mingyao Liu
openalex +1 more source
Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Advanced Science, EarlyView.Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang +4 more
wiley +1 more source
How Does Misinformation Spill-Over Spatially? New Evidence from COVID-19 Drug Treatment Endorsements
, 2021 Bansal A, Chatterjee C, Kumar A.
europepmc +1 more source
Quantum mechanical studies of the adsorption of Remdesivir, as an effective drug for treatment of COVID-19, on the surface of pristine, COOH-functionalized and S-, Si- and Al- doped carbon nanotubes [PDF]
, 2021 Samaneh Bagheri Novir +1 more
openalex +1 more source
Drug Resistance Predictions Based on a Directed Flag Transformer
Advanced Science, EarlyView.CAPTURE, a deep learning framework combining structural and sequence data to predict drug‐resistant Mpro mutations, revealing that PAXLOVID use may be accelerating resistance—supporting real‐time viral surveillance and therapeutic design. Abstract The evolving SARS‐CoV‐2 virus threatens global public health, particularly with potential resistance to ...
Dong Chen +8 more
wiley +1 more source
Anticancer drugs and COVID-19 antiviral treatments in patients with cancer: What can we safely use?
, 2020 Paul Gougis +6 more
openalex +2 more sources
Machine Learning‐Enhanced Nanoparticle Design for Precision Cancer Drug Delivery
Advanced Science, EarlyView.Machine Learning (ML) is revolutionizing cancer nanomedicine by optimizing nanoparticle (NP) design and drug delivery. This review summarizes ML applications across all stages of NP drug delivery, along with a discussion of ongoing challenges and future directions.
Qingquan Wang +5 more
wiley +1 more source