Results 101 to 110 of about 13,629 (283)

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, Volume 12, Issue 25, July 3, 2025.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

Necrotic Ulcerated Lesion in a Young Boy Caused by Cowpox Virus Infection

Case Reports in Dermatology, 2011
The case presented here points towards the fact that skin lesion observed with a cowpox virus is a rare event but should be considered more as the number of cases has increased in the last years. Cowpox virus (CPXV) belongs to the Poxviridae family.
Anne-Laure Favier, Olivier Flusin, Sébastien Lepreux, Hervé Fleury, Christine Labrèze, Aurélie Georges, Jean-Marc Crance, Franck Boralevi   +7 more
doaj   +1 more source

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, Volume 12, Issue 26, July 10, 2025.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

Antiviral activities of two nucleos(t)ide analogs against vaccinia, mpox, and cowpox viruses in primary human fibroblasts

Antiviral Research, 2023
Lara Dsouza, Anil Pant, Samuel Offei, Lalita Priyamvada, B. Pope, P. Satheshkumar, Zhengqiang Wang, Zhilong Yang   +7 more
semanticscholar   +1 more source

Companion Animals as a Source of Viruses for Human Beings and Food Production Animals [PDF]

, 2016
Companion animals comprise a wide variety of species, including dogs, cats, horses, ferrets, guinea pigs, reptiles, birds and ornamental fish, as well as food production animal species, such as domestic pigs, kept as companion animals.
Brown, I.H. (Ian), Haenen, O.L., Jong, M.D. (Menno) de, Kuiken, T. (Thijs), Osterhaus, A.D.M.E. (Albert), Papa, A. (Anna), Reperant, L.A. (Leslie), Rimstad, E., Valarcher, J.-F.   +8 more
core   +4 more sources

Optical Method for the Detection of Viral RNA Using an Optical Fiber Sensor

Journal of Biophotonics, Volume 18, Issue 7, July 2025.
This study presents a fiber‐optic sensor with a microsphere tip functionalized with a gold layer and oligonucleotide probes for detecting SARS‐CoV‐2 RNA at concentrations as low as 10−12 M in near real time. ABSTRACT This study introduces a fiber‐optic sensor functionalized with a sensing probe for SARS‐CoV‐2 RNA detection.
Patryk Sokołowski, Paweł Wityk, Joanna Raczak‐Gutknecht, Wiktoria Brzezińska, Michał Sobaszek, Paweł Kalinowski, Sebastian Garcia‐Galan, Małgorzata Szczerska   +7 more
wiley   +1 more source

Experimental Cowpox Virus (CPXV) Infections of Bank Voles: Exceptional Clinical Resistance and Variable Reservoir Competence

Viruses, 2017
Cowpox virus (CPXV) is a zoonotic virus and endemic in wild rodent populations in Eurasia. Serological surveys in Europe have reported high prevalence in different vole and mouse species.
A. Franke, R. Ulrich, Saskia Weber, N. Osterrieder, M. Keller, D. Hoffmann, M. Beer   +6 more
semanticscholar   +1 more source

Increased susceptibility of Cantagalo virus to the antiviral effect of ST-246® [PDF]

, 2013
Cantagalo virus (CTGV) is the etiologic agent of a pustular disease in dairy cows and dairy workers in Brazil with important economical and occupational impacts. Nevertheless, no antiviral therapy is currently available.
Beltrame, Cristiana O., Byrd, Chelsea M., Cardwell, Kara B., Damaso, Clarissa R., Hruby, Dennis E., Jordan, Robert, Medaglia, Maria Luiza G., Santos-Fernandes, Élida, Schnellrath, Laila C.   +8 more
core   +1 more source

Interdisciplinary Approach to Monkeypox Prevention: Integrating Nanobiosensors, Nanovaccines, Artificial Intelligence, Visual Arts, and Social Sciences

Small Structures, Volume 6, Issue 7, July 2025.
This illustration depicts a comprehensive strategy against monkeypox, showcasing its transmission, symptoms, and prevention. Centralized around nanomaterials and biosensors, it integrates early screening, Internet of Things, vaccination, and community involvement through collaboration among healthcare workers, scientists, researchers, social groups ...
Vishal Chaudhary, Lucky Lucky, Harsh Sable, Nikhil Bhalla   +3 more
wiley   +1 more source

Morphology of deoxyribonucleic acid extracted from cores of vaccinia virus [PDF]

, 1967
It has been shown recently that the outer layers of vaccinia virions can be removed selectively under mild conditions to yield a preparation that consists entirely of "cores" (K. B. Easterbrook, Ultrastruct. Res. 14:484, 1966).
Easterbrook, K. B.
core