Results 71 to 80 of about 5,076 (170)

Repurpose an FDA‐Approved Antibody Using DARPin‐Scaffolded Bridge Protein

Chemistry–Methods, Volume 6, Issue 5, May 2026.
The cell line and scalable upstream/downstream process development needed for every new monoclonal antibody are both highly expensive and time‐consuming, significantly increasing the cost of new antibody therapeutics. By contrast, the production of many synthetic binders can be accomplished rapidly and with lower production costs.
Michael Woolley, Joshua D. Bryant, Samuel Vrana, Karuppiah Chockalingam, Zhilei Chen   +4 more
wiley   +1 more source

Cowpox virus. [PDF]

British Journal of Ophthalmology, 1992
W N Dugmore, Z M Dabir
openaire   +1 more source

Cowpox virus virulence determinants

, 2019
New cowpox virus (CPXV) infections occur naturally in Germany in increasing numbers. It is striking that an infection of the pet rats with these newly occurring CPXV strains often leads to a lethal outcome. Likewise, a CPXV isolate from a pet rat that as well caused human infection in Southern Germany, RatPox09, causes severe disease in Wistar rats ...
openaire   +2 more sources

Study of Vaccinia and Cowpox viruses' replication in Rac1-N17 dominant-negative cells

Memorias do Instituto Oswaldo Cruz, 2013
Interfering with cellular signal transduction pathways is a common strategy used by many viruses to create a propitious intracellular environment for an efficient replication.
Ana Paula Carneiro Salgado, Jamária Adriana Pinheiro Soares-Martins, Luciana Garcia Andrade, Jonas Dutra Albarnaz, Paulo César Peregrino Ferreira, Erna Geessien Kroon, Cláudio Antônio Bonjardim   +6 more
doaj   +1 more source

Fatal Cowpox Virus Infection in Human Fetus, France, 2017. [PDF]

Emerg Infect Dis, 2021
Ferrier A, Frenois-Veyrat G, Schvoerer E, Henard S, Jarjaval F, Drouet I, Timera H, Boutin L, Mosca E, Peyrefitte C, Ferraris O.   +10 more
europepmc   +1 more source

Readiness Level of Spanish Labs to Detect Mpox Clade Ib: A Nationwide EQA

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT To assess the preparedness and diagnostic capacity of Spanish clinical microbiology laboratories to detect the emerging monkeypox virus (MPXV) Clade Ib through a nationwide external quality assessment. A blinded 16‐sample panel (serum and DNA eluates) containing MPXV Clade Ib, Clade II, vaccinia, and negatives was distributed.
Adolfo De Salazar, Anabel Negredo, Juan Carlos Galán, Teresa Del Peso, Marta Illescas, Laura Martínez‐García, Concepción Gimeno, Federico García, María Paz Sánchez‐Seco, the QC Mpox Spain Collaborators, Sonia Algarate, Andrés Antón, Ana Milagro, Fernando Buñuel, Laura Calatayud, Pilar Catalán, Gregorio Marañón, Marta Domínguez‐Gil González, Manel Flores, Pablo Fraile, Ana Fuentes López, María del Carmen Garma, Mª Dolores Gómez‐Ruíz, Mónica Gozalo, Manuel Grau, Almudena Gutiérrez‐Arroyo, Silvia Hernáez, Águeda Hernández‐Rodríguez, Noelia Hernando, Flor Isabel Hidalgo, José Luis Juan, Eduardo Lagarejos, Miguel Julián Martínez‐Yoldi, Santiago Melón, Pablo Mendoza, Laura Merino, Milagrosa Montes, Jordi Niubó, María Dolores Ocete, Alejandra Pérez‐García, Jorge Alfredo Pérez‐García, Mercedes Pérez‐Ruiz, Sonia Pérez‐Castro, Jordi Reina, Romina Soledad Romero, Genoveva Santillana, Encarna Simarro, Mikel Urruticoechea, Laura Herrero, Francisca Molero   +49 more
wiley   +1 more source

Intrabronchial inoculation of cynomolgus macaques with cowpox virus

Journal of General Virology, 2012
The public health threat of orthopoxviruses from bioterrorist attacks has prompted researchers to develop suitable animal models for increasing our understanding of viral pathogenesis and evaluation of medical countermeasures (MCMs) in compliance with the FDA Animal Efficacy Rule.
Alvin L, Smith, Marisa, St Claire, Srikanth, Yellayi, Laura, Bollinger, Peter B, Jahrling, Jason, Paragas, Joseph E, Blaney, Reed F, Johnson   +7 more
openaire   +2 more sources

Complex Approach to Species-Specific Detection of Cowpox Virus

Проблемы особо опасных инфекций, 2016
Objective of the study is to develop and validate the method for species-specific detection of cowpox virus (CPV). Materials and methods. Utilized were oligonucleotide primers and fluorescence-labeled probes for genus-specific detection of ...
R. A. Maksyutov
doaj   +1 more source

Replication of cowpox virus in macrophages is dependent on the host range factor p28/N1R. [PDF]

Virol J, 2021
Bourquain D, Schrick L, Tischer BK, Osterrieder K, Schaade L, Nitsche A.   +5 more
europepmc   +1 more source

Human Cytomegalovirus Infection in Haematopoietic Stem Cell Transplant Recipients and CAR‐T Cell Recipients—PART 2: Antiviral Therapy and Virus‐Specific T Cell Therapy for HCMV in Allo‐HSCT

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT Human cytomegalovirus (HCMV) reactivation is a common and significant complication after allogeneic haematopoietic stem cell transplantation (allo‐HSCT), causing potentially life‐threatening disease. Antiviral therapy approaches for HCMV are often limited by toxicities and the risk of developing antiviral drug resistance.
Gaurav Sutrave, Michelle K. Yong, Danya Kaplan, David J. Gottlieb, Allison Abendroth, Barry Slobedman, Emily Blyth, Lauren Stern   +7 more
wiley   +1 more source