Results 11 to 20 of about 755,483 (324)

Ku80 cooperates with CBP to promote COX-2 expression and tumor growth. [PDF]

, 2015
Cyclooxygenase-2 (COX-2) plays an important role in lung cancer development and progression. Using streptavidin-agarose pulldown and proteomics assay, we identified and validated Ku80, a dimer of Ku participating in the repair of broken DNA double ...
Chen, Yiming, Cheng, Wei, Dai, Meng, Deng, Wuguo, Du, Sha, Guo, Wei, Hu, Wenxian, Huang, Wenlin, Jia, Yunlu, Li, Mei, Li, Zhenglin, Liu, Quentin, Meng, Songshu, Qin, Yu, Wang, Jingshu, Wang, Shusen, Wu, Taihua, Xiao, Xiangsheng, Xiao, Yao, Xuan, Yang, Yi, Canhui, Yu, Wendan, Yuan, Yuhui, Zhao, Shilei   +23 more
core   +3 more sources

Systematic study of constitutive cyclo-oxygenase-2 expression: role of NFκB and NFAT transcriptional pathways [PDF]

, 2015
Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs (NSAIDs).
Ahmetaj-Shala, B, Berglund, LM, Chan, MV, Garcia-Vaz, E, Gomez, MF, Herschman, HR, Jiao, J, Kirkby, NS, Mitchell, JA, Verdu, EF, Wallace, JL, Zaiss, AK   +11 more
core   +1 more source

COX-2 chronology [PDF]

Gut, 2005
The role of selective cyclooxygenase (COX)-2 inhibitors in medical practice has become controversial since evidence emerged that their use is associated with an increased risk of myocardial infarction. Selective COX-2 inhibitors were seen as successor to non-selective non-steroidal anti-inflammatory drugs, in turn successors to aspirin.
openaire   +2 more sources

Targeting Biomarkers of Proliferation and Inflammation (Ki67, p53, and COX-2) in Actinic Keratoses with Photodynamic Therapy. [PDF]

Biomedicines
Ceryn J, Lesiak A, Ciążyńska M, Sobolewska-Sztychny D, Noweta M, Stasikowska-Kanicka O, Ciążyński K, Zalaudek I, Narbutt J.   +8 more
europepmc   +3 more sources

Selective COX-2 inhibitors and risk of myocardial infarction [PDF]

, 2005
Selective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids.
Klauss, V., Krotz, F., Schiele, T. M., Sohn, Hae-Young   +3 more
core   +1 more source

Pancreatic Stellate Cells (PSCs) express Cyclooxygenase-2 (COX-2) and pancreatic cancer stimulates COX-2 in PSCs

Molecular Cancer, 2005
Background Cyclooxygenase 2 (COX-2), the inducible form of prostaglandin G/H synthase, is associated with several human cancers including pancreatic adenocarcinoma.
Denham Woody, Bell Richard H, Talamonti Mark S, Pelham Carolyn, Ding Xian-Zhong, Ujiki Michael, Yoshida Seiya, Adrian Thomas E   +7 more
doaj   +1 more source

Nimesulide Induced Histopathological Changes in the Vas Deferens of Mice [PDF]

Journal of Clinical and Diagnostic Research, 2013
Aim: Nimesulide, a preferential COX-2 inhibitor has 20 times more selectivity towards COX-2 than that of COX-1. COX-2 selective inhibitors cause frequent nephrotoxicity and hepatotoxicity following their usage.
Thotakura Balaji, Manickam Subramanian, Vaithianathan Gnanasundaram, Sharmila Saran Raj Endran, Hannah Sugirthabai Rajila Rajendran   +4 more
doaj   +1 more source

Kaempferol Improves Breast Cancer-Related Depression through the COX-2/PGE2 Pathway

Frontiers in Bioscience-Landmark, 2023
Background: Breast cancer-related depression (BCRD) is strongly associated with BC and increases recurrence and mortality. This study investigated the role of kaempferol in the pathogenesis of BCRD and its underlying mechanism.
Qing Zhu, Yuanshan Han, Ying He, Yilan Fu, Hui Yang, Yun Chen, Yingrui Shi   +6 more
doaj   +1 more source

Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity. [PDF]

, 2007
he important role of cyclooxygenase-2 (COX-2) in the pathogenesis of inflammation and side effect limitations of current COX-2 inhibitor drugs illustrates a need for the design of new compounds based on alternative structural templates.
ANZELLOTTI P, ANZINI M., BIAVA M, BOTTA M, CAPPELLI A, FORLI S, GHELARDINI C, MAKOVEC F, MANETTI, F, PATRIGNANI P, PERGOLA, CARLO, POCE G, PORRETTA GC, ROSSI, ANTONIETTA, ROVINI M, SAUTEBIN, LIDIA, SUPINO S, VIVOLI E   +17 more
core   +1 more source

The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer [PDF]

, 2005
<b>OBJECTIVE</b>: To test the hypothesis that angiogenesis in prostate cancer is associated with tumour invasion and metastasis, and that this is mediated through increased cyclooxygenase-2 (COX-2) expression.
Bartlett, J.M.S., Edwards, J., Mukherjee, R., Underwood, M.A.   +3 more
core   +1 more source