Results 21 to 30 of about 757,334 (297)

Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats [PDF]

, 2007
Several studies suggest that cyclooxygenase (COX)-2 plays a pivotal role in the progression of ischemic brain damage. In the present study, we investigated the effects of selective inhibition of COX-2 with nimesulide (12 mg/kg) and selective inhibition ...
Candelario-Jalil, Eduardo, Fiebich, Bernd, Garcia-Cabrera, Michel, Gonzalez-Falcon, Armando, Leon, Olga Sonia   +4 more
core   +2 more sources

Amantadine produces analgesia through a unique mechanism and pharmacokinetics in chickens [PDF]

Iraqi Journal of Veterinary Sciences
Nowadays, there is a requisite for worthy and effective analgesic drugs with the least side effects for proper use in veterinary medicine. The goal was to relate amantadine (AMN) pharmacodynamics (i.e. analgesia and COX-2 inhibition) with a preferential (
Faisal F. Idris, Yaareb J. Mousa
doaj   +1 more source

Cyclooxygenase-2-Prostaglandin E2 pathway: A key player in tumor-associated immune cells

Frontiers in Oncology, 2023
Cyclooxygenases-2 (COX-2) and Prostaglandin E2 (PGE2), which are important in chronic inflammatory diseases, can increase tumor incidence and promote tumor growth and metastasis.
Kaipeng Jin, Kaipeng Jin, Kaipeng Jin, Chao Qian, Chao Qian, Chao Qian, Jinti Lin, Jinti Lin, Jinti Lin, Bing Liu, Bing Liu, Bing Liu   +11 more
doaj   +1 more source

Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer [PDF]

, 2016
In patients with colorectal cancer (CRC), local and systemic inflammatory responses have been extensively reported to associate with cancer survival. However, the specific signalling pathways responsible for inflammatory responses are not clear. The PTEN/
Bennett, Lindsay, Edwards, Joanne, Horgan, Paul G., McMillan, Donald C., Park, James, Powell, Arfon G.M.T., Roseweir, Antonia K., Van Wyk, Hester C.   +7 more
core   +3 more sources

Synthesis of 2-Methyl-3-indolylacetic Derivatives as Anti-Inflammatory Agents That Inhibit Preferentially Cyclooxygenase 1 without Gastric Damage [PDF]

, 2006
Novel substituted 2-methyl-3-indolylacetic derivatives were synthesized and evaluated for their activity in vitro and in vivo on COX-1 and COX-2. Active compounds were screened to determine their gastrointestinal tolerability in vivo in the rat.
C. Renner, CALIENDO, GIUSEPPE, CIRINO, GIUSEPPE, FIORINO, FERDINANDO, PERISSUTTI, ELISA, ROSSI, ANTONIETTA, ROVIEZZO, FIORENTINA, SANTAGADA, VINCENZO, SAUTEBIN, LIDIA, SEVERINO, BEATRICE   +9 more
core   +1 more source

Hidden Cardiotoxicity of Rofecoxib Can be Revealed in Experimental Models of Ischemia/Reperfusion

Cells, 2020
Cardiac adverse effects are among the leading causes of the discontinuation of clinical trials and the withdrawal of drugs from the market. The novel concept of ‘hidden cardiotoxicity’ is defined as cardiotoxicity of a drug that manifests in ...
Gábor B. Brenner, András Makkos, Csilla Terézia Nagy, Zsófia Onódi, Nabil V. Sayour, Tamás G. Gergely, Bernadett Kiss, Anikó Görbe, Éva Sághy, Zoltán S. Zádori, Bernadette Lázár, Tamás Baranyai, Richárd S. Varga, Zoltán Husti, András Varró, László Tóthfalusi, Rainer Schulz, István Baczkó, Zoltán Giricz, Péter Ferdinandy   +19 more
doaj   +1 more source

The Role of Prostaglandins in Different Types of Cancer

Cells, 2021
The prostaglandins constitute a family of lipids of 20 carbon atoms that derive from polyunsaturated fatty acids such as arachidonic acid. Traditionally, prostaglandins have been linked to inflammation, female reproductive cycle, vasodilation, or ...
Álvaro Jara-Gutiérrez, Victoriano Baladrón   +1 more
doaj   +1 more source

Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. [PDF]

, 2011
Based on its capacity to inhibit in vitro HIV-1 replication in T cells and the release of pro-inflammatory cytokines in monocytes, the prenylated heterodimeric phloroglucinyl α-pyrone arzanol was identified as the major anti-inflammatory and anti-viral ...
Appendino G, Bauer J, Dehm F, Koeberle A, Northoff H, Pollastro F, ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, Werz O.   +8 more
core   +1 more source

Pharmacodynamic and Pharmacokinetic Comparison between Selective and Non-selective COX-2 Inhibitors in Mice [PDF]

Journal of Applied Veterinary Sciences
Nowadays, there is a need for good and efficacious NSAIDs with minimal side effects to be applied in veterinary medicine. The aim was to compare the pharmacodynamics (analgesia and inhibition of COX-2) and pharmacokinetics between selective (nimesulide ...
Taimaa Yahya, Yaareb Mousa
doaj   +1 more source

Kaempferol Improves Breast Cancer-Related Depression through the COX-2/PGE2 Pathway

Frontiers in Bioscience-Landmark, 2023
Background: Breast cancer-related depression (BCRD) is strongly associated with BC and increases recurrence and mortality. This study investigated the role of kaempferol in the pathogenesis of BCRD and its underlying mechanism.
Qing Zhu, Yuanshan Han, Ying He, Yilan Fu, Hui Yang, Yun Chen, Yingrui Shi   +6 more
doaj   +1 more source