Results 11 to 20 of about 757,334 (297)

Ku80 cooperates with CBP to promote COX-2 expression and tumor growth. [PDF]

, 2015
Cyclooxygenase-2 (COX-2) plays an important role in lung cancer development and progression. Using streptavidin-agarose pulldown and proteomics assay, we identified and validated Ku80, a dimer of Ku participating in the repair of broken DNA double ...
Chen, Yiming, Cheng, Wei, Dai, Meng, Deng, Wuguo, Du, Sha, Guo, Wei, Hu, Wenxian, Huang, Wenlin, Jia, Yunlu, Li, Mei, Li, Zhenglin, Liu, Quentin, Meng, Songshu, Qin, Yu, Wang, Jingshu, Wang, Shusen, Wu, Taihua, Xiao, Xiangsheng, Xiao, Yao, Xuan, Yang, Yi, Canhui, Yu, Wendan, Yuan, Yuhui, Zhao, Shilei   +23 more
core   +3 more sources

Systematic study of constitutive cyclo-oxygenase-2 expression: role of NFκB and NFAT transcriptional pathways [PDF]

, 2015
Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs (NSAIDs).
Ahmetaj-Shala, B, Berglund, LM, Chan, MV, Garcia-Vaz, E, Gomez, MF, Herschman, HR, Jiao, J, Kirkby, NS, Mitchell, JA, Verdu, EF, Wallace, JL, Zaiss, AK   +11 more
core   +1 more source

COX-2 chronology [PDF]

Gut, 2005
The role of selective cyclooxygenase (COX)-2 inhibitors in medical practice has become controversial since evidence emerged that their use is associated with an increased risk of myocardial infarction. Selective COX-2 inhibitors were seen as successor to non-selective non-steroidal anti-inflammatory drugs, in turn successors to aspirin.
openaire   +2 more sources

Transactivation of EGFR by LPS induces COX-2 expression in enterocytes [PDF]

, 2012
Necrotizing enterocolitis (NEC) is the leading cause of gastrointestinal morbidity and mortality in preterm infants. NEC is characterized by an exaggerated inflammatory response to bacterial flora leading to bowel necrosis.
A Grishin, AA Fanaroff, AA Maynard, Anatoly Grishin, AO Fagbemi, AV Grishin, B Dvorak, B Lugo, BB Warner, BJ Stoll, BK Reuter, CE Shin, CL Leaphart, Claus Schneider, CP Sodhi, D Hsu, D. Brent Polk, DH Chung, Henri Ford, JA Clark, Jeffrey Upperman, JL Koff, Jörn-Hendrik Weitkamp, M Fukata, M Fukata, M Petrosyan, MD Halpern, Michael J. Rosen, Michael Kallen, Nathalie Signoret, Noemi Tejera, O Morteau, P Chailler, PJ Miettinen, Poojitha Matta, PW Lin, RR Nair, S Cetin, SC Fitzgibbons, SC Gribar, SC Gribar, SO Guthrie, Steven J. McElroy, Stuart Hobbs, T Jilling, T Yamaoka   +45 more
core   +3 more sources

Pancreatic Stellate Cells (PSCs) express Cyclooxygenase-2 (COX-2) and pancreatic cancer stimulates COX-2 in PSCs

Molecular Cancer, 2005
Background Cyclooxygenase 2 (COX-2), the inducible form of prostaglandin G/H synthase, is associated with several human cancers including pancreatic adenocarcinoma.
Denham Woody, Bell Richard H, Talamonti Mark S, Pelham Carolyn, Ding Xian-Zhong, Ujiki Michael, Yoshida Seiya, Adrian Thomas E   +7 more
doaj   +1 more source

Selective COX-2 inhibitors and risk of myocardial infarction [PDF]

, 2005
Selective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids.
Klauss, V., Krotz, F., Schiele, T. M., Sohn, Hae-Young   +3 more
core   +1 more source

Dimethyl Fumarate Alleviates Dextran Sulfate Sodium-Induced Colitis, through the Activation of Nrf2-Mediated Antioxidant and Anti-inflammatory Pathways. [PDF]

, 2020
Oxidative stress and chronic inflammation play critical roles in the pathogenesis of ulcerative colitis (UC) and inflammatory bowel diseases (IBD). A previous study has demonstrated that dimethyl fumarate (DMF) protects mice from dextran sulfate sodium ...
Farzaneh, Ted, Ichii, Hirohito, Lau, Hien, Li, Shiri, Robles, Lourdes, Stamos, Michael J, Takasu, Chie, Vaziri, Nosratola D, Vo, Kelly   +8 more
core   +2 more sources

Evaluation of the immunoexpression of COX-1, COX-2 and p53 in Crohn's disease Avaliação da imunoexpressão de COX-1, COX-2 e p53 na doença de Crohn

Arquivos de Gastroenterologia, 2008
BACKGROUND: Crohn's disease accompanied by nonspecific or idiopathic ulcerative proctocolitis corresponds to a condition called intestinal inflammatory disease.
Mônica Romero, Ricardo Artigiani, Henrique Costa, Celina Tizuko Fujiyama Oshima, Sender Miszputen, Marcello Franco   +5 more
doaj   +1 more source

The role of macrophage migration inhibitory factor in promoting benign prostatic hyperplasia epithelial cell growth by modulating COX-2 and P53 signaling

Biology Open, 2020
Inflammation and proinflammatory cytokines have been implicated in the progression of benign prostatic hyperplasia (BPH). Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine. Our previous study found that MIF is highly expressed in
Hualin Song, Qi Shen, Shuai Hu, Jie Jin
doaj   +1 more source

Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors

Saudi Pharmaceutical Journal, 2023
This review highlights the potential role of cyclooxygenase-2 enzyme (COX-2) in the pathogenesis of Alzheimer's disease (AD) and the potential therapeutic use of non-steroidal anti-inflammatory drugs (NSAIDs) in the management of AD. In addition to COX-2
Nathalie Moussa, Ninar Dayoub
doaj   +1 more source