Results 241 to 250 of about 755,483 (324)

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Baicalin Mitigates <i>Pasteurella multocida</i>-Induced Pulmonary and Vascular Injury via NLRP3/COX-2 Inhibition in Mice. [PDF]

Animals (Basel)
Zhang D, Zhao C, Xue Y, Lu Q, Liu Y, Xiong J, Ye C, Fu S, Wu Z, Qiu Y, Guo P.   +10 more
europepmc   +1 more source

COX-2 and COX-2 enzyme inhibition.

International journal of immunopathology and pharmacology, 2004
openaire   +1 more source

COX-2を指標とした放射線誘発バイスタンダー細胞応答に関する研究Analysis of radiation induced bystander response by COX-2 induction in A549 human lung carcinoma cells（18SJ05）

, 2021
小林 亜利紗, 大澤 大輔, Nahathai Dukaew, Autosavapromporn Narongchai, Ahbrizal Farizal Tengku Ahmad Tengku, 小西 輝昭   +5 more
openalex   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

The interplay between COX-2, chemotherapeutic drugs, and chemoresistance in colon cancer. [PDF]

Sci Rep
Shalaby SM, Shawky SA, Ashour H, Sarhan W.   +3 more
europepmc   +1 more source

Flavonoids targeting of I&kappa;B phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells

, 2011
Borhane Annabi, Elizabeth Tahanian, Luis Arguello Sanchez, Tze Chieh Shiao, René Roy   +4 more
openalex   +2 more sources

Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer

Advanced Science, EarlyView.
Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Wenhan Li, Feiquan Ying, Xinkai Pang, Qiulei Wu, Guoqing Li, Lin Huang, Jiayu Xin, Xiaoli Liu, Pan Liu, Xiaohan Xu, Shuran Tan, Yumei Gao, Tong Liu, Si Sun, Xiaoman Wang, Yiping Wen, Liqiong Cai, Shi Du, Yuan Zhang, Jing Cai   +19 more
wiley   +1 more source

Integrating COX-2, stromal PD-L1, and T-cell infiltration enhances prognostic stratification in colorectal cancer. [PDF]

BMC Cancer
Topi G, Sjölander A, Satapathy SR.
europepmc   +1 more source

Osteocyte expression of caspase-3, COX-2, IL-6 and sclerostin are spatially and temporally associated following stress fracture initiation

, 2014
Andy Wu, L. J. Kidd, Nicholas Cowling, Wendy L. Kelly, Mark R. Forwood   +4 more
openalex   +2 more sources