Results 251 to 260 of about 757,334 (297)
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The Lancet, 1999
In the past 100 years aspirin has demonstrated its value as an analgesic, anti-inflammatory, and antithrombotic agent. However, by 1938, it was clear that aspirin was gastrotoxic. Non-steroidal anti-inflammatory drugs (NSAIDs), developed since the 1960s, failed to achieve the goal of "a safer aspirin". The demonstration that inhibition of prostaglandin
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In the past 100 years aspirin has demonstrated its value as an analgesic, anti-inflammatory, and antithrombotic agent. However, by 1938, it was clear that aspirin was gastrotoxic. Non-steroidal anti-inflammatory drugs (NSAIDs), developed since the 1960s, failed to achieve the goal of "a safer aspirin". The demonstration that inhibition of prostaglandin
+11 more sources
Journal of Cardiovascular Pharmacology, 2006
Inflammation plays a central role in the development of atherosclerotic disease, from the early phases of lesion formation to plaque disruption, the main underlying cause of acute ischemic syndromes. Arachidonic acid metabolism is implicated in the pathophysiology of ischemic syndromes affecting the coronary or cerebrovascular territory, as ...
CIPOLLONE, Francesco +1 more
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Inflammation plays a central role in the development of atherosclerotic disease, from the early phases of lesion formation to plaque disruption, the main underlying cause of acute ischemic syndromes. Arachidonic acid metabolism is implicated in the pathophysiology of ischemic syndromes affecting the coronary or cerebrovascular territory, as ...
CIPOLLONE, Francesco +1 more
openaire +3 more sources
Current Pharmaceutical Design, 2007
It wasn't until 1990, when the existence of two different cyclooxygenases was hypothesized, based on the evidence that steroids inhibited the increase in COX activity induced by bacterial lipopolysaccharides in macrophages, without any effects on the basal production of prostaglandins or leukotrienes.
Iezzi A. +3 more
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It wasn't until 1990, when the existence of two different cyclooxygenases was hypothesized, based on the evidence that steroids inhibited the increase in COX activity induced by bacterial lipopolysaccharides in macrophages, without any effects on the basal production of prostaglandins or leukotrienes.
Iezzi A. +3 more
openaire +3 more sources
Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 2001
(2001). COX-2 and ALS. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders: Vol. 2, No. 3, pp. 121-122.
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(2001). COX-2 and ALS. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders: Vol. 2, No. 3, pp. 121-122.
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