Results 41 to 50 of about 755,483 (324)

Contribution of non-steroidal anti-inflammatory drugs to breast cancer treatment: In vitro and in vivo studies [PDF]

Veterinary World
Chronic inflammation plays a crucial role in carcinogenesis. High levels of serum prostaglandin E2 and tissue overexpression of cyclooxygenase-2 (COX-2) have been described in breast, urinary, colorectal, prostate, and lung cancers as being involved in ...
Tiago Ferreira, I. Faustino-Rocha, Vítor M. Gaspar, Rui Medeiros, João F. Mano, Paula A. Oliveira   +5 more
doaj   +1 more source

An Insight of Co-Encapsulation Nigella sativa and Cosmos caudatus Kunth Extracts as Anti-Inflammatory Agent Through In Silico Study

Jurnal Kimia Sains dan Aplikasi, 2021
This study analyzes anti-inflammatory activity from extracts of Nigella sativa and Cosmos caudatus Kunth co-encapsulated through in silico molecular docking. The LC-MS results revealed that extracts of N.
Nadiyah Zuhroh, Zubaidah Ningsih, Anna Safitri   +2 more
doaj   +1 more source

Cyclic AMP increases COX-2 expression via mitogen-activated kinase in human myometrial cells [PDF]

, 2012
Cyclic AMP (cAMP) is the archetypal smooth muscle relaxant, mediating the effects of many hormones and drugs. However, recently PGI2, acting via cAMP/PKA, was found to increase contraction-associated protein expression in myometrial cells and to promote ...
Amsen, Blumenfeld, Cao, Faour, Fetalvero, Goldenberg, Jung, Kaminski, Kirtikara, Klein, Landau, Martin, Matsuura, Mehats, Meloni, Minguet, Mohan, Olson, Oyesanya, Schmitz, Schroer, Simhan, Simpkin, Slater, Sooranna, Sparey, Ster, Streicher, Subbaramaiah, Sun, Wadhwa, Wu, Xu, Yaqub, Yin, Zakar   +35 more
core   +2 more sources

Could TNF-antagonists be a novel treatment strategy for BPH patients?

Cell Stress, 2022
Cytotoxic therapies, such as chemotherapy and radiotherapy, are mainstays of cancer treatment for both early and unresectable, advanced disease. In addition to debulking the tumour mass through direct killing of proliferating tumour cells, these ...
Charlotte R. Bell, Santiago Zelenay
doaj   +1 more source

Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis. [PDF]

, 2016
Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional regulation of tumor-promoting genes such as COX-2, TNFα and VEGF. Overexpression of
Aguado, Andrea, Anant, Shrikant, Blanco, Fernando F., Brody, Jonathan R., Dixon, Dan A., Meisner-Kober, Nicole, Padhye, Subhash, Preet, Ranjan, Stevens, Laura E., Vishwakarma, Vikalp, Vyas, Alok, Weir, Scott J., Xu, Liang   +12 more
core   +2 more sources

Antioxidant and Anti-inflammatory Activities of Salacca zalacca (Gaertn.) Peel Extract on Pb-induced Fibroblast Cells

Journal of Nature and Science of Medicine
Background: Salacca zalacca is a plant indigenous to Indonesia that consists of skin, pulp, and seed. The skin of S. zalacca, typically disposed of as waste, displays antioxidant and anti-inflammatory qualities.
Ermi Girsang, Chrismis Novalinda Ginting, I Nyoman Ehrich Lister, Fadhilah Haifa Zahiroh, Hanna Sari Widya Kusuma, Wahyu Widowati   +5 more
doaj   +1 more source

Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats [PDF]

, 2007
Several studies suggest that cyclooxygenase (COX)-2 plays a pivotal role in the progression of ischemic brain damage. In the present study, we investigated the effects of selective inhibition of COX-2 with nimesulide (12 mg/kg) and selective inhibition ...
Candelario-Jalil, Eduardo, Fiebich, Bernd, Garcia-Cabrera, Michel, Gonzalez-Falcon, Armando, Leon, Olga Sonia   +4 more
core   +2 more sources

Survival for Children Diagnosed With Wilms Tumour (2012–2022) Registered in the UK and Ireland Improving Population Outcomes for Renal Tumours of Childhood (IMPORT) Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga, Angela Lopez‐Cortes, Reem Al‐Saadi, Suzanne Tugnait, Kristina Dzhuma, Catriona Duncan, Gordan Vujanic, Tanzina Chowdhury, Claudia Allemani, Michel P. Coleman, Kathy Pritchard‐Jones, the Children's Cancer and Leukaemia Group (CCLG) Renal Tumour Special Interest Group, Hugh Bishop, Anthony McCarthy, Pamela Kearns, Helen Rees, Amos Burke, Meriel Jenney, Jane Pears, Hamish Wallace, Milind Ronghe, Tanzina Chowdhury, Susan Picton, Emma Ross, Lisa Howell, Bernadette Brennan, Gail Halliday, Richard Grundy, Shaun Wilson, Sucheta Vaidya, Daniel Yeomanson, Jessica Bate, Vesna Pavasovic, Jessica Bate, Sabine Irtan, Jesper Brok, Minou Oostveen, Kristina Dzhuma, Mark Weeks, Richard Williams, Mark Powis, Max Pachl, Bruce Okoye, Naima Smeulders, Gordan Vujanic, Oystein Olsen, Tom Watson, Susan Shelmerdine, Dan Saunders, Angela Lopez-Cortes, Taryn Treger, Tom Jackson, Suzanne Tugnait, Lisa Howell, Tanzina Chowdhury, Sam Behjati, Angela Polanco   +56 more
wiley   +1 more source

Tolerance to alternative cyclooxygenase-2 inhibitors in nonsteroidal anti-inflammatory drug hypersensitive patients [PDF]

, 2013
Background: Non-steroidal anti-inflammatory drugs (NSAIDs) frequently cause adverse drug reactions. Many studies have shown that drugs which selectively inhibit the cyclooxygenase-2 enzyme (COX-2) are safe alternatives in the majority of patients ...
Bruijnzeel-Koomen, C.A., Knulst, A.C. (André), Malskat, W.S.J. (Wendy), Röckmann, H. (Heike)   +3 more
core   +1 more source

A Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Surveillance imaging aims to detect tumour relapse before symptoms develop, but it's unclear whether earlier detection of relapse leads to better outcomes in children and young people (CYP) with medulloblastoma and ependymoma. This systematic review aims to identify relevant literature to determine the efficacy of surveillance magnetic ...
Lucy Shepherd, Melissa Taylor, Helen Fulbright, Bob Phillips   +3 more
wiley   +1 more source