Results 151 to 160 of about 26,709,678 (285)

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Design, synthesis, and biological evaluation of a new series of amide-linked chalcone derivatives as selective COX-2 inhibitors. [PDF]

RSC Adv
Shamim A, Nadeem H, Hussain T, Rehman A, Masaud SM, Ayaz S, Bashir K, Latif M, Alrokayan S, Ali H, Irshad N.   +10 more
europepmc   +1 more source

New NSAID Conjugates as Potent and Selective COX-2 Inhibitors: Synthesis, Molecular Modeling and Biological Investigation. [PDF]

Molecules, 2023
Bokhtia RM, Panda SS, Girgis AS, Samir N, Said MF, Abdelnaser A, Nasr S, Bekheit MS, Dawood AS, Sharma H, Wade M, Sharma SK, Ghanim AM.   +12 more
europepmc   +1 more source

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Selective COX-2 inhibitors for short-term musculoskeletal pain in inflammatory bowel disease in remission: a narrative review. [PDF]

BMJ Open Gastroenterol
van Nieuwenhoven MA.
europepmc   +1 more source

The Search for Cyclooxygenase-2 (COX-2) Inhibitors for the Treatment of Inflammation Disease: An in-silico Study. [PDF]

J Multidiscip Healthc, 2022
Ruslin R, Yamin Y, Kasmawati H, Mangrura S, Kadidae L, Alroem A, Arba M.   +6 more
europepmc   +1 more source

Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: anti-inflammatory and analgesic activities.

European journal of medicinal chemistry, 2015
A. Alanazi, A. El-Azab, Ibrahim A. Al-Suwaidan, K. Eltahir, Y. Asiri, Naglaa I. Abdel-Aziz, A. Abdel-Aziz   +6 more
semanticscholar   +1 more source

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

Design, Synthesis, and Evaluation of Bis-Chalcones and Bis-Flavones as Selective COX-2 Inhibitors. [PDF]

Chem Biol Drug Des
Pereira R, Freitas M, Araújo AN, Silva VLM, Fernandes E.   +4 more
europepmc   +1 more source

Antiinflammation Derived Suzuki-Coupled Fenbufens as COX-2 Inhibitors: Minilibrary Construction and Bioassay. [PDF]

Molecules, 2022
Farn SS, Lai YB, Hua KF, Chen HP, Yu TY, Lo SN, Shen LH, Sheu RJ, Yu CS.   +8 more
europepmc   +1 more source