Results 181 to 190 of about 26,709,678 (285)

Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives as novel anti-cancer, dual EGFR^WT/COX-2 inhibitors with docking studies. [PDF]

RSC Adv, 2023
Reda N, Elshewy A, El-Askary HI, Mohamed KO, Helwa AA.   +4 more
europepmc   +1 more source

Comparative gastrointestinal toxicity of selective cyclooxygenase (COX-2) inhibitors

, 2005
614-619Cyclooxygenase (COX-2) inhibitors were developed with the hope that they will cause fewer gastrointestinal adverse effects. Ability of selective as well as nonselective COX inhibitors to alter ischemia-reperfusion induced damage of gastric ...
Malhotra, S, Pandhi, P, Nada, R, Shafiq, N   +3 more
core  

Sonoselective Transfection of Glioma Endothelium

Advanced Science, EarlyView.
Delivering non‐viral, gene‐bearing nanoparticles with thiol‐decorated surfaces to gliomas with focused ultrasound yields transfection tropism for endothelial cells. From this platform, “sonoselective” transfection of glioma endothelium is achieved via incorporation of an endothelial cell‐specific promoter.
Anna C. Debski, Catherine M. Gorick, Victoria R. Breza, Jackson Tirrell, Krishan Perumal, Katherine M. Nowak, Ji Song, Natasha D. Sheybani, Richard J. Price   +8 more
wiley   +1 more source

Identification of Enhanced Cyclooxygenase-2 (COX-2) Inhibitors Beyond Curcumin Through Virtual Screening to Target Inflammation-Related Metabolic Complications. [PDF]

Int J Mol Sci
Moetlediwa MT, Ramashia R, Mangale MB, Pheiffer C, Jack BU, Salifu EY, Ramharack P.   +6 more
europepmc   +1 more source

COX-2 Inhibitors Decrease Expression of PD-L1 in Colon Tumors and Increase the Influx of Type I Tumor-infiltrating Lymphocytes. [PDF]

Cancer Prev Res (Phila), 2022
Cecil DL, Gad EA, Corulli LR, Drovetto N, Lubet RA, Disis ML.   +5 more
europepmc   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Cross-Reactivity and Cross-Intolerance Among Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Clinical Patterns, COX-1-Mediated Mechanisms, and Implications for COX-2 Inhibitors and Paracetamol. [PDF]

Int J Mol Sci
Andryszkiewicz W, Lippik M, Makieła M, Modrzyk B, Gomułka K.   +4 more
europepmc   +1 more source

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

Phytocompounds in Precision Dermatology: COX-2 Inhibitors as a Therapeutic Target in Atopic-Prone Skin. [PDF]

Biomolecules
Suleman M, Sayaf AM, Moltrasio C, Tricarico PM, Giambuzzi F, Rimondi E, Melloni E, Secchiero P, Marcuzzi A, Marzano AV, Crovella S.   +10 more
europepmc   +1 more source

Rational Design and Synthesis of New Selective COX-2 Inhibitors with In Vivo PGE2-Lowering Activity by Tethering Benzenesulfonamide and 1,2,3-Triazole Pharmacophores to Some NSAIDs. [PDF]

Pharmaceuticals (Basel), 2022
El-Dershaby NH, El-Hawash SA, Kassab SE, Daabees HG, Abdel Moneim AE, El-Miligy MMM.   +5 more
europepmc   +1 more source