Results 11 to 20 of about 39,333 (253)
Cyclooxygenase 1(COX1) polymorphisms in African-American and caucasian populations [PDF]
Human Mutation, 2002 Cyclooxygenases (COXs) are the primary targets of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs), and thus enzymes of major interest to pharmacology, pharmacogenetics, and epidemiology. Genetic variants that affect enzyme function, or the interaction with NSAIDs, could alter drug response.
Cornelia M. Ulrich +6 more
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Defective COX1 expression in aging mice liver [PDF]
Biology Open, 2023 ABSTRACT Mitochondrial defects are associated with aging processes and age-related diseases, including cardiovascular diseases, neurodegenerative diseases and cancer. In addition, some recent studies suggest mild mitochondrial dysfunctions appear to be associated with longer lifespans.
Steffen Witte +5 more
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Circulation Research, 2019 Rationale: Endothelial cells (ECs) and platelets, which respectively produce antithrombotic prostacyclin and prothrombotic thromboxane A 2 , both express COX1 (cyclooxygenase1). Consequently, there has been no way to delineate any antithrombotic role for COX1-derived prostacyclin from ...
Jane A. Mitchell +8 more
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An Ancient Fission of Mitochondrial cox1 [PDF]
Molecular Biology and Evolution, 2009 Many genes inherited from the alpha-proteobacterial ancestor of mitochondria have undergone evolutionary transfer to the nuclear genome in eukaryotes. In some rare cases, genes have been functionally transferred in pieces, resulting in split proteins that presumably interact in trans within mitochondria, fulfilling the same role as the ancestral ...
Ryan M.R. Gawryluk, Michael W. Gray
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The Carboxyl-terminal End of Cox1 Is Required for Feedback Assembly Regulation of Cox1 Synthesis in Saccharomyces cerevisiae Mitochondria [PDF]
Journal of Biological Chemistry, 2010 Synthesis of the largest cytochrome c oxidase (CcO) subunit, Cox1, on yeast mitochondrial ribosomes is coupled to assembly of CcO. The translational activator Mss51 is sequestered in early assembly intermediate complexes by an interaction with Cox14 that depends on the presence of newly synthesized Cox1. If CcO assembly is prevented, the level of Mss51
Miguel Shingú-Vázquez +5 more
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Molecular and biochemical analysis of Saccharomyces cerevisiae cox1 mutants [PDF]
Current Genetics, 1998 We report on the molecular and biochemical analysis of a set of 13 respiratory deficient mutants of Saccharomyces cerevisiae which are specifically altered in COX1, the gene encoding the subunit Cox1p of cytochrome c oxidase. DNA sequence analysis shows that three are due to frameshift mutations, two to nonsense mutations, and eight to missense ...
Lemaire, C., Robineau, S., Netter, P.
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Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly [PDF]
The EMBO Journal, 2007 Cytochrome c oxidase (complex IV) of the respiratory chain is assembled from nuclear and mitochondrially-encoded subunits. Defects in the assembly process lead to severe human disorders such as Leigh syndrome. Shy1 is an assembly factor for complex IV in Saccharomyces cerevisiae and mutations of its human homolog, SURF1, are the most frequent cause for
Mick, David U. +8 more
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Swarms of diversity at the gene cox1 in Antarctic krill [PDF]
Heredity, 2010 The Antarctic krill, Euphausia superba, is an abundant and key species found in the Southern Ocean that forms dense, discrete swarms. Despite over three decades of research on Antarctic krill, the genetics of individual swarms is yet to be specifically investigated.
Goodall-Copestake, WP +5 more
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Human mitochondrial COX1 assembly into cytochrome c oxidase at a glance [PDF]
Journal of Cell Science, 2015 Mitochondria provide the main portion of cellular energy in form of ATP produced by the F1Fo ATP synthase, which uses the electrochemical gradient, generated by the mitochondrial respiratory chain (MRC). In human mitochondria, the MRC is composed of four multisubunit enzyme complexes, with the cytochrome c oxidase (COX, also known as complex IV) as the
Sven Dennerlein, Peter Rehling
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Frontiers in Veterinary Science, 2020 Coenurus cerebralis is the larval stage of Taenia multiceps commonly found in the brain (cerebral form), intramuscular and subcutaneous tissues (non-cerebral form) of ungulates.
Mughees Aizaz Alvi +12 more
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