Results 61 to 70 of about 1,415,363 (344)
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Testing and interpreting assumptions of COX regression analysis
Cancer Research, Statistics, and Treatment, 2019 The COX regression analysis is like any statistical test that is based on multiple assumptions. This is a guide for how to test the assumptions and how to interpret the results.
Sampada Dessai, Vijay Patil
doaj +1 more source
Healthcare Analytics, 2023 There are potentially infinite gene expression markers for Lung Squamous Cell Carcinoma. This results in a high-dimensional data with a large number of features. The selection of relevant markers for analysis is thus, of utmost importance.
Atanu Bhattacharjee +2 more
doaj +1 more source
Estimates of influenza vaccine effectiveness in primary care in Scotland vary with clinical or laboratory endpoint and method : experience across the 2010/11 season [PDF]
, 2013 Aim: This study examines estimation of seasonal influenza vaccine effectiveness (VE) for a cohort of patients attending general practice in Scotland in 2010/11.
Kavanagh, Kimberley +2 more
core +3 more sources
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Model Regresi Cox Proportional Hazards Pada Data Lama Studi Mahasiswa (Studi Kasus Di Fakultas Sains Dan Matematika Universitas Diponegoro Semarang Mahasiswa Angkatan 2009) [PDF]
, 2014 High education has important role to increase the intellectual life of the nation and the development of natural sciences and technology by producing the quality graduates. The quality graduates just need 48 month to finish the study.
Hutahaean, L. P. (Landong) +2 more
core
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh +8 more
wiley +1 more source
Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice [PDF]
, 2007 Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Angioni, Carlo Federico +8 more
core +1 more source
Expression of COX-1 and COX-2 in a Clinical Model of Acute Inflammation [PDF]
The Journal of Pain, 2007 Cyclooxygenase (COX) plays an important role in the induction of pain and inflammation as well as the analgesic actions of NSAIDs and coxibs. This study evaluates the expression of the two isoforms COX-1 and COX-2 in a clinical model in which the surgical removal of impacted third molars is used to evaluate the analgesic activity of anti-inflammatory ...
Raymond A. Dionne +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source