Results 61 to 70 of about 1,497,781 (343)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Healthcare Analytics, 2023 There are potentially infinite gene expression markers for Lung Squamous Cell Carcinoma. This results in a high-dimensional data with a large number of features. The selection of relevant markers for analysis is thus, of utmost importance.
Atanu Bhattacharjee +2 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
From Transience to Recurrence for Cox–Ingersoll–Ross Model When b < 0
Mathematics, 2023 We consider the Cox–Ingersoll–Ross (CIR) model in time-dependent domains, that is, the CIR process in time-dependent domains reflected at the time-dependent boundary.
Mingli Zhang, Gaofeng Zong
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Statistical model on student performance in UTHM by using non-parametric, semi-parametric and parametric survival analysis [PDF]
, 2019 Student performance defined as students who are capable to success during their studies. This study explored the use of survival analysis to investigate the performance of Bachelor’s degree students in Universiti Tun Hussein Onn Malaysia (UTHM). The data
Che Hamat, Che Azmeeza
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice [PDF]
, 2007 Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Angioni, Carlo Federico +8 more
core +1 more source
Expression of COX-1 and COX-2 in a Clinical Model of Acute Inflammation [PDF]
The Journal of Pain, 2007 Cyclooxygenase (COX) plays an important role in the induction of pain and inflammation as well as the analgesic actions of NSAIDs and coxibs. This study evaluates the expression of the two isoforms COX-1 and COX-2 in a clinical model in which the surgical removal of impacted third molars is used to evaluate the analgesic activity of anti-inflammatory ...
Asma A, Khan +3 more
openaire +2 more sources