Results 41 to 50 of about 40,521 (233)

SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication. [PDF]

, 2016
Accumulating evidence suggests that viruses hijack cellular proteins to circumvent the host immune system. Ubiquitination and SUMOylation are extensively studied posttranslational modifications (PTMs) that play critical roles in diverse biological ...
Gong, P, Hu, Q, Ke, X, Liu, Y, Meng, J, Shu, B, Wang, H, Zhang, Y, Zheng, C, Zheng, Z   +9 more
core   +1 more source

CARD8 makes coxsackievirus more “heartbreaking”

Journal of Experimental Medicine, 2022
In this issue of JEM, Nadkarni et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20212117) identify CARD8 as an innate sensor triggered by coxsackievirus B3 proteases to drive pyroptosis of aortic endothelial cells and cardiac myocytes, fueling viral replication and heart inflammation.
Qiankun Wang, Liang Shan
openaire   +2 more sources

Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. [PDF]

, 2017
The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions.
Cadwell, Ken, Debnath, Jayanta
core   +1 more source

Coxsackievirus B3, Shandong Province, China, 1990–2010

Emerging Infectious Diseases, 2012
To determine the cause of a 2008 outbreak of aseptic meningitis in Shandong Province, China, we analyzed samples from outbreak patients and coxsackievirus B3 samples collected during 1990–2010 surveillance. The cause of the outbreak was coxsackievirus B3,
Zexin Tao, Yanyan Song, Yan Li, Yao Liu, Ping Jiang, Xiaojuan Lin, Guifang Liu, Lizhi Song, Haiyan Wang, Aiqiang Xu   +9 more
doaj   +1 more source

A Kidnapping Story: How Coxsackievirus B3 and Its Host Cell Interact.

Cellular Physiology and Biochemistry, 2019
Infections with Coxsackievirus B3 and other members of the enterovirus genus are a common reason for myocarditis and sudden cardiac death in modern society.
S. Peischard, H. Ho, C. Theiss, N. Strutz‐Seebohm, G. Seebohm   +4 more
semanticscholar   +1 more source

Cathepsin B aggravates coxsackievirus B3-induced myocarditis through activating the inflammasome and promoting pyroptosis

PLoS Pathogens, 2018
Cathepsin B (CatB) is a cysteine proteolytic enzyme widely expressed in various cells and mainly located in the lysosomes. It contributes to the pathogenesis and development of many diseases. However, the role of CatB in viral myocarditis (VMC) has never
Yaping Wang, L. Jia, Jian Shen, Yi-dong Wang, Zurong Fu, Sheng'an Su, Zhejun Cai, Jian-an Wang, Meixiang Xiang   +8 more
semanticscholar   +1 more source

Coxsackie-adenovirus receptor expression is enhanced in pancreas from patients with type 1 diabetes [PDF]

, 2016
Objectives: One of the theories connecting enterovirus (EV) infection of human islets with type 1 diabetes (T1D) is the development of a fertile field in the islets.
Alhazmi, A, Anagandula, M, Anagandula, M, Anquetil-Besnard, F, Atkinson, M, Breuer, J, Burch, T, Campbell-Thompson, M, Chapman, N, Clare-Salzler, M, Dahl-Jørgensen, K, Depledge, D, Domsgen, E, Dotta, F, Dyahal, S, Eizirik, D, Flodström Tullberg, M, Frisk, G, Frisk, G, Fuxe, J, Gerling, I, Gianani, R, Giepmans, B, Hodik, M, Homann, D, Horwitz, M, Hyöty, H, Hyöty, H, Jelmer, W, Kaddis, J, Kakoola, D, Kalicharan, R, Kent, S, Krogvold, L, Kuipers, J, Kusmartseva, I, Laiho, J, Larsson, P, Leete, P, Lenchik, N, Lloyd, R, Mancarella, F, Marjomaki, V, Morgan, N, Morris, M, Nadler, J, Nigi, L, Nyalwidhe, J, Oikarnen, M, OpDeBeeck, A, Patti, A, Petrosino, J, Piemonti, L, Plagnol, V, Pugliese, A, Richardson, S, Rodriguez-Calvo, T, Russell, M, Sabouri, S, Sarimiento, L, Sarkar, S, Sarmiento, L, Sebastiani, G, Smithee, S, Toniolo, A, Tracy, S, Ventriglia, G, von Herrath, M, Wolters, A, Yang, M   +69 more
core   +1 more source

Update on coxsackievirus B3 myocarditis [PDF]

Current Opinion in Rheumatology, 2012
To present recent findings on the pathogenesis of coxsackievirus B3 (CVB3) myocarditis based on animal models, with a focus on the role of T helper (Th) immune responses in disease progression.Acute CVB3 myocarditis is known to be increased by Th1 immune responses, but recent findings indicate that Th1-type immunity protects against acute myocarditis ...
DeLisa, Fairweather, Katelyn A, Stafford, Yoon K, Sung   +2 more
openaire   +2 more sources

Emerging Coxsackievirus A6 Causing Hand, Foot and Mouth Disease, Vietnam

Emerging Infectious Diseases, 2018
Hand, foot and mouth disease (HFMD) is a major public health issue in Asia and has global pandemic potential. Coxsackievirus A6 (CV-A6) was detected in 514/2,230 (23%) of HFMD patients admitted to 3 major hospitals in southern Vietnam during 2011–2015 ...
N. T. Anh, L. Nhu, H. Van, N. Hong, T. T. Thanh, V. Hang, N. Ny, L. A. Nguyet, T. Phuong, L. Nhan, N. T. Hung, T. H. Khanh, H. M. Tuan, H. Viet, Nguyen Tran Nam, D. C. Viet, P. Qui, B. Wills, Sarawathy Sabanathan, N. Chau, L. Thwaites, H. Rogier van Doorn, G. Thwaites, M. Rabaa, Le Van Tan   +24 more
semanticscholar   +1 more source

A transcriptomic investigation of handicap models in sexual selection [PDF]

, 2014
We are grateful to D. Calder and T. Helps for access to study sites, and G. Murray-Dickson and M. Oliver for help with fieldwork and comments on manuscript drafts. This work was funded by NERC grant NE/D000602/1 (SBP), a NERC advanced fellowship (FM) and
Martinez-Padilla, Jesus, Mougeot, Francois, Paterson, Steve, Piertney, Stuart B., Webster, Lucy M. I., Wenzel, Marius Alexander   +5 more
core   +1 more source