Results 51 to 60 of about 22,089 (224)

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways

Viruses, 2016
To successfully replicate, viruses protect their genomic material from degradation by the host cell. RNA viruses must contend with numerous destabilizing host cell processes including mRNA decay pathways and viral RNA (vRNA) degradation resulting from ...
Wendy Ullmer, Bert L. Semler
doaj   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Preocular Tear Film Tests in Acute Hemorrhagic Conjunctivitis Caused by Coxsackievirus A24 Variant

, 2012
Pur po se: Our aim was to evaluate the preocular tear film in patients who had acute hemorrhagic conjunctivitis (AHC) caused by coxsackievirus A24 variant (CVA24v).
Evre Pekel, Engin Faik Azman, Burhan Babaoğlu, Yusuf Avni Yılmaz, Şenol Sabancı, Gökhan Pekel, Sezen Harmancı   +6 more
core   +1 more source

Pentavalent Sialic Acid Conjugates Block Coxsackievirus A24 Variant and Human Adenovirus Type 37 – Viruses That Cause Highly Contagious Eye Infections

, 2020
Coxsackievirus A24 variant (CVA24v) and human adenovirus 37 (HAdV-37) are leading causative agents of the severe and highly contagious ocular infections acute hemorrhagic conjunctivitis and epidemic keratoconjunctivitis, respectively.
thilo, stehle, Rebecca, Thompson, Naresh, Chandra, Nitesh, Mistry, Emil, Johansson, Georg, Zocher, Mikael, Elofsson, Daniel L., Hurdiss, Weixing, Qian, Lars, Frängsmyr, C. David, Andersson, Niklas, Arnberg, Rémi, Caraballo   +12 more
core   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Molecular epidemiology of Coxsackievirus B3

Infection, Genetics and Evolution, 2010
Molecular epidemiological characteristics are needed to understand the impact of Coxsackievirus B3 (CV-B3) infection, since no CV-B3 genotyping literature is available. Twenty-nine CV-B3 Taiwan strains obtained from 1992 to 2005 were analyzed. A phylogenetic tree was constructed based on the 290 nucleotide sequence of the VP1 gene of Taiwan isolates ...
Pei-Yu, Chu, Guan-Ming, Ke, Yao-Shen, Chen, Po-Liang, Lu, Hsiu-Lin, Chen, Min-Sheng, Lee, Bao-Chen, Chen, Tsi-Shu, Huang, Yu-Chen, Li, Li-Chiu, Chou, Sheng-Yu, Wang, Kuei-Hsiang, Lin   +11 more
openaire   +2 more sources

Molecular Phylogeny of Coxsackievirus A16 [PDF]

Journal of Clinical Microbiology, 2014
We have read the article by [Zong et al.][1] with considerable interest ([1][2]). They described the molecular phylogeny of Coxsackievirus A16 (CVA16) in Shenzhen, China, from 2005 to 2009. In their paper, they claimed that “Subtype B2 could be further divided into clusters B2a, B2b, and B2c ...
Ting, Sun, Yiming, Liu, Yanjun, Zhang, Linfu, Zhou   +3 more
openaire   +2 more sources

Search for Coxsackievirus B3 RNA in idiopathic dilated cardiomyopathy using gene amplification by polymerase chain reaction

, 1992
A polymerase chain reaction (PCR) amplification assay was developed to detect Coxsackievirus B3 ribonucleic acid (RNA) in blood and myocardial tissue of explanted hearts from 40 patients who underwent cardiac transplantation and in 1 normal heart. Twenty-
Arbustini E., Vigano M., Bramerio M., Gavazzi A., Diegoli M., Percivalle E., Grasso M., Silini E., Ratti G., Milanesi G.   +9 more
core   +1 more source