Human picornaviruses associated with neurological diseases and their neutralization by antibodies [PDF]
, 2017 Picornaviruses are the most commonly encountered infectious agents in mankind. They typically cause mild infections of the gastrointestinal or respiratory tract, but sometimes also invade the central nervous system.
Ang +22 more
core +1 more source
Induction of cytopathic effect and cytokines in coxsackievirus B3-infected murine astrocytes [PDF]
, 2013 BACKGROUND: Coxsackievirus commonly infects children and occasionally causes severe meningitis and/or encephalitis in the newborn. The underlying mechanism(s) behind the central nervous system pathology is poorly defined. METHODS: It is hypothesized that
Dangui Zhang +7 more
core +1 more source
Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody
Nature Communications, 2017 Coxsackievirus A6 (CVA6) has recently emerged as a major cause of hand, foot and mouth disease in children worldwide but no vaccine is available against CVA6 infections.
Longfa Xu +22 more
semanticscholar +1 more source
Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways
Viruses, 2016 To successfully replicate, viruses protect their genomic material from degradation by the host cell. RNA viruses must contend with numerous destabilizing host cell processes including mRNA decay pathways and viral RNA (vRNA) degradation resulting from ...
Wendy Ullmer, Bert L. Semler
doaj +1 more source
Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease
Emerging Infectious Diseases, 2020 Hand, foot and mouth disease (HFMD) is an emerging infection with pandemic potential. Knowledge of neutralizing antibody responses among its pathogens is essential to inform vaccine development and epidemiologic research.
Lam Anh Nguyet +23 more
doaj +1 more source
The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding
Animal Research and One Health, EarlyView.A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang +10 more
wiley +1 more source
An outbreak of acute haemorrhagic conjunctivitis associated with coxsackievirus A24 variant in The Gambia, West Africa. [PDF]
, 2017 OBJECTIVE: An outbreak of acute haemorrhagic conjunctivitis occurred in The Gambia, West Africa in 2011. Affected individuals presented with conjunctival haemorrhages, swelling and ocular discharge.
Bailey, Robin L +4 more
core +1 more source
ESC Heart Failure, EarlyView.Proposed management of myo‐pericardial diseases. A systematic interdisciplinary approach to myo‐pericardial disease is essential to reach a correct diagnosis, starting from multiparametric characterization including EKG, echocardiography with GLS, laboratory exams and CMR or, in case of electric or haemodynamic instability, EMB.
Marco Merlo +18 more
wiley +1 more source
Enteroviruses and T1D: Is It the Virus, the Genes or Both which Cause T1D
Microorganisms, 2020 Type 1 diabetes (T1D) is a chronic autoimmune disorder that results from the selective destruction of insulin-producing β-cells in the pancreas. Up to now, the mechanisms triggering the initiation and progression of the disease are, in their complexity ...
Shirin Geravandi +2 more
doaj +1 more source
Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells [PDF]
, 2011 Coxsackievirus B (CVB), a member of the enterovirus family, targets the polarized epithelial cells lining the intestinal tract early in infection. Although the polarized epithelium functions as a protective barrier, this barrier is likely exploited by ...
Bergelson, JM +6 more
core +1 more source