Results 21 to 30 of about 14,514 (174)

Coxsackie Virus and its Effect on Human Health: A review

مجلة التربية والعلم
In low- and middle-income countries, coxsackievirus infections constitute a serious public health concern, especially for young children and newborns.
Manar Fawzi Altaie, Elaph Madallah Shuwaikh AL-Qaisi, Anmar Ahmed Altaie   +2 more
doaj   +1 more source

Coxsackievirus and Adenovirus Receptor Cytoplasmic and Transmembrane Domains Are Not Essential for Coxsackievirus and Adenovirus Infection [PDF]

Journal of Virology, 1999
ABSTRACTCoxsackievirus and adenovirus receptor (CAR) from which the cytoplasmic domain had been deleted and glycosylphosphatidylinositol (GPI)-anchored CAR lacking both transmembrane and cytoplasmic domains were both capable of facilitating adenovirus 5-mediated gene delivery and infection by coxsackievirus B3.
X, Wang, J M, Bergelson
openaire   +2 more sources

Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance. [PDF]

PLoS Pathogens, 2011
The rise in type 1 diabetes (T1D) incidence in recent decades is probably related to modifications in environmental factors. Viruses are among the putative environmental triggers of T1D.
Maikel L Colli, Tatiane C Nogueira, Florent Allagnat, Daniel A Cunha, Esteban N Gurzov, Alessandra K Cardozo, Merja Roivainen, Anne Op de Beeck, Decio L Eizirik   +8 more
doaj   +1 more source

Persistent viral infections and their role in heart disease

Frontiers in Microbiology, 2022
Viral infections are the culprit of many diseases, including inflammation of the heart muscle, known as myocarditis. Acute myocarditis cases have been described in scientific literature, and viruses, such as parvovirus B19, coxsackievirus B3, or more ...
Ashwin Badrinath, Sagar Bhatta, Anna Kloc   +2 more
doaj   +1 more source

Recurrent Coxsackievirus Infection in a Patient with Lamellar Ichthyosis [PDF]

Pediatric Dermatology, 2016
AbstractWe describe a case of coxsackievirus (CV) A6 infection in a patient with lamellar ichthyosis followed by subsequent CV A8 infection within the same year. Atypical cutaneous features characterized the infection. This observation, combined with the rapidity with which reinfection occurred, suggests that the natural history of CV infection may be ...
William E, Damsky, Jonathan S, Leventhal, David, Khalil, Matthew D, Vesely, Brittany G, Craiglow, Leonard M, Milstone, Keith A, Choate   +6 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Novel Antiviral Activity of Ethyl 3-Hydroxyhexanoate Against Coxsackievirus B Infection

Frontiers in Microbiology, 2022
Coxsackievirus group B (CVB) is a member of the genus Enterovirus in the family Picornaviridae. CVB infection has been implicated as a major etiologic agent of viral myocarditis, dilated cardiomyopathy, meningitis, and pancreatitis among children and ...
Oluwatayo Israel Olasunkanmi, James Mageto, Juval Avala Ntsigouaye, Ming Yi, Yanru Fei, Yang Chen, Sijia Chen, Weizhen Xu, Lexun Lin, Wenran Zhao, Yan Wang, Zhao-Hua Zhong   +11 more
doaj   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches

Animal Models and Experimental Medicine, EarlyView.
This review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Milad Faraji, Maedeh Faraji, Nasrin Kazemipour   +2 more
wiley   +1 more source

The Role of B Lymphocytes in Coxsackievirus B3 Infection [PDF]

The American Journal of Pathology, 1999
Coxsackieviruses are important human pathogens, frequently causing myocarditis, pancreatitis, and a variety of less severe diseases. B lymphocytes appear central to the interaction between these viruses and their mammalian hosts, because agammaglobulinemic humans, genetically incapable of antibody production, are susceptible to chronic infections by ...
I, Mena, C M, Perry, S, Harkins, F, Rodriguez, J, Gebhard, J L, Whitton   +5 more
openaire   +2 more sources