Results 31 to 40 of about 817,924 (155)

Persistent viral infections and their role in heart disease

Frontiers in Microbiology, 2022
Viral infections are the culprit of many diseases, including inflammation of the heart muscle, known as myocarditis. Acute myocarditis cases have been described in scientific literature, and viruses, such as parvovirus B19, coxsackievirus B3, or more ...
Ashwin Badrinath, Sagar Bhatta, Anna Kloc   +2 more
doaj   +1 more source

Old disease, new twist

Journal of Hospital Medicine, EarlyView.
Abstract An 81‐year‐old man with a history of high‐grade urothelial carcinoma of the bladder and ureter on treatment with atezolizumab and tiragolumab presented to the emergency department with 5 months of malaise, generalized weakness, and fatigue and 2 weeks of subjective fevers. One month prior to presentation, he received an empiric 9‐day course of
Hadi Roudsari, Gurpreet Dhaliwal, Anand D. Jagannath, Alan H. Baik, Sam Brondfield   +4 more
wiley   +1 more source

Novel Antiviral Activity of Ethyl 3-Hydroxyhexanoate Against Coxsackievirus B Infection

Frontiers in Microbiology, 2022
Coxsackievirus group B (CVB) is a member of the genus Enterovirus in the family Picornaviridae. CVB infection has been implicated as a major etiologic agent of viral myocarditis, dilated cardiomyopathy, meningitis, and pancreatitis among children and ...
Oluwatayo Israel Olasunkanmi, James Mageto, Juval Avala Ntsigouaye, Ming Yi, Yanru Fei, Yang Chen, Sijia Chen, Weizhen Xu, Lexun Lin, Wenran Zhao, Yan Wang, Zhao-Hua Zhong   +11 more
doaj   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Sphingosine‐1‐Phosphate Attenuates LPS‐Induced Inflammatory Cardiac Injury in Association With RASGRP1–S100A9–NLRP3 Signaling

Drug Development Research, Volume 87, Issue 7, November 2026.
ABSTRACT Lipopolysaccharide (LPS) induces endotoxemia‐associated inflammatory cardiac injury rather than classical viral or autoimmune myocarditis. Sphingosine‐1‐phosphate (S1P) regulates cardiovascular and immune responses, predominantly through S1P receptors, but whether it also modulates macrophage‐associated inflammatory signaling during LPS ...
Chaofu Yue, Qiaolin Li, Chunyan Li, Taoxian Yang, Xian Huang, Feng Yue, Qiuyu Long, Rong Li, Rong Lei, Qingsong Ma, Caimei Hu, Qian Yang, Yongjun Yan, Yuan Liu, QinYong Yan, Mei Yang   +15 more
wiley   +1 more source

Polyomavirus Drives Cerebellar Lesions in AIDS Monkeys With Ataxia

MedComm, Volume 7, Issue 11, November 2026.
Chronic SIV‐infected macaques with ataxia develop severe cerebellar lesions driven by simian polyomavirus 40 (SV40) infection. SV40 preferentially infects cerebellar granule cells, inducing pyroptosis and an aberrant proliferative state. Pyroptotic neuronal injury promotes microglial recruitment and activation, amplifying local neuroinflammation and ...
Tian‐Zhang Song, Li‐Rong Zhang, Yun‐Mei Wang, Yan Hu, Qing Li, Ren‐Rong Tian, Liu‐Meng Yang, Si‐Dong Xiong, Dong‐Dong Wu, Yong‐Tang Zheng   +9 more
wiley   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, Volume 13, Issue 57, 14 October 2026.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Outbreak of hand, foot and mouth disease/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study [PDF]

, 2012
Hand, foot and mouth disease (HFMD) and herpangina (HA) are frequently caused by several distinct serotypes belonging to the human enterovirus A species (HEVA).
S. Ughetto, Henquell, C., Bailly, J.-L., A. Mirand, D. Antona, C. Henquell, H. Peigue-Lafeuille, Antona, D., Archimbaud, C., J.-L. Bailly, Mirand, A., Ughetto, S., C. Archimbaud, Peigue-Lafeuille, H.   +13 more
core   +1 more source

Antiviral activity of the dihydroquercetin during the Coxsackievirus В4 replication in vitro

Вопросы вирусологии, 2016
A study of the antiviral activity of antioxidants against viral infections is believed to be essential for creating complex antiviral agents. Dihydroquercetin is considered as the most active antioxidant extracted from larix gmelinii.
A. V. Galochkina, V. V. Zarubaev, O. I. Kiselev, V. A. Babkin, L. A. Ostroukhova   +4 more
doaj   +1 more source

Cross‐Neutralizing and Broadly Neutralizing Human Antibodies Against Nonenveloped Viruses

European Journal of Immunology, Volume 56, Issue 10, October 2026.
In this review article, Marchand et al. compare cross ‐ and broadly ‐neutralizing human antibodies against non ‐ enveloped viruses from several major families, discussing their structural characteristics, neutralization mechanisms and relevance for the development of antiviral vaccines and therapeutics.
Sarah Marchand, Samy Taouli, Dorian McIlroy   +2 more
wiley   +1 more source