Results 41 to 50 of about 20,829 (225)

Genetic diversity of Coxsackievirus A21 associated with sporadic cases of acute respiratory infections in Malaysia

BMC Infectious Diseases, 2021
Background Coxsackievirus A21 (CVA21), a member of Enterovirus C from the Picornaviridae family, has been associated with respiratory illnesses in humans.
Nur Izzati Supian, Kim Tien Ng, Jack Bee Chook, Yutaka Takebe, Kok Gan Chan, Kok Keng Tee   +5 more
doaj   +1 more source

Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination

iScience, 2022
Summary: Viral respiratory tract infections exacerbate airway disease and facilitate life-threatening bacterial colonization in cystic fibrosis (CF). Annual influenza vaccination is recommended and vaccines against other common respiratory viruses may ...
Virginia M. Stone, Renata Utorova, Marta Butrym, Amir-Babak Sioofy-Khojine, Minna M. Hankaniemi, Emma E. Ringqvist, Marfa Blanter, Anirudra Parajuli, Terezia Pincikova, Björn Fischler, Ferenc Karpati, Vesa P. Hytönen, Heikki Hyöty, Lena Hjelte, Malin Flodström-Tullberg   +14 more
doaj   +1 more source

Induction of cytopathic effect and cytokines in coxsackievirus B3-infected murine astrocytes [PDF]

, 2013
BACKGROUND: Coxsackievirus commonly infects children and occasionally causes severe meningitis and/or encephalitis in the newborn. The underlying mechanism(s) behind the central nervous system pathology is poorly defined. METHODS: It is hypothesized that
Dangui Zhang, Gang Xin, Gefei Wang, Jun Zeng, Kangsheng Li, Weizhong Li, Xiaoxuan Chen, Zhiwu Jiang   +7 more
core   +1 more source

Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance. [PDF]

PLoS Pathogens, 2011
The rise in type 1 diabetes (T1D) incidence in recent decades is probably related to modifications in environmental factors. Viruses are among the putative environmental triggers of T1D.
Maikel L Colli, Tatiane C Nogueira, Florent Allagnat, Daniel A Cunha, Esteban N Gurzov, Alessandra K Cardozo, Merja Roivainen, Anne Op de Beeck, Decio L Eizirik   +8 more
doaj   +1 more source

Persistent viral infections and their role in heart disease

Frontiers in Microbiology, 2022
Viral infections are the culprit of many diseases, including inflammation of the heart muscle, known as myocarditis. Acute myocarditis cases have been described in scientific literature, and viruses, such as parvovirus B19, coxsackievirus B3, or more ...
Ashwin Badrinath, Sagar Bhatta, Anna Kloc   +2 more
doaj   +1 more source

Enhancement of coxsackievirus B3 infection by antibody to a different coxsackievirus strain [PDF]

Journal of General Virology, 2002
Group B coxsackieviruses (CVBs) are a major cause of viral myocarditis and pancreatitis in humans and produce a similar pattern of disease in inbred strains of mice. As there are six strains of CVBs, individuals can be infected with multiple serotypes.
Jaskamal, Girn, Mojgan, Kavoosi, Janet, Chantler   +2 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Novel Antiviral Activity of Ethyl 3-Hydroxyhexanoate Against Coxsackievirus B Infection

Frontiers in Microbiology, 2022
Coxsackievirus group B (CVB) is a member of the genus Enterovirus in the family Picornaviridae. CVB infection has been implicated as a major etiologic agent of viral myocarditis, dilated cardiomyopathy, meningitis, and pancreatitis among children and ...
Oluwatayo Israel Olasunkanmi, James Mageto, Juval Avala Ntsigouaye, Ming Yi, Yanru Fei, Yang Chen, Sijia Chen, Weizhen Xu, Lexun Lin, Wenran Zhao, Yan Wang, Zhao-Hua Zhong   +11 more
doaj   +1 more source

Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda. [PDF]

, 2019
Febrile illness is a major burden in African children, and non-malarial causes of fever are uncertain. In this retrospective exploratory study, we used metagenomic next-generation sequencing (mNGS) to evaluate serum, nasopharyngeal, and stool specimens ...
Byaruhanga, Oswald, de Bourcy, Charles, DeRisi, Joseph L, Dimitrov, Boris, Egger, Rebecca, Hsu, Jennifer, Juan, Yun-Fang, Kalantar, Katrina, Kyohere, Mary, Langelier, Charles, Mpimbaza, Arthur, Nakielny, Sara, Ramesh, Akshaya, Rosenthal, Philip J, Ruel, Theodore, Sheu, Jonathan, Wang, James, Wilson, Michael R   +17 more
core   +3 more sources

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source