Results 91 to 100 of about 196,785 (313)

Elastic stiffening of reservoir rocks with rising pore pressure under constant biaxial far-field stress: application to the Porthos geological carbon-dioxide sequestration project

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
This study systematically quantifies elastic stiffening in fluid-saturated porous media, distinguishing the critical influence of biaxial far-field stress from simplified uniaxial conditions. The Linear Superposition Method (LSM) of elastic displacements
Axel Dorian Piepi Toko, Ruud Weijermars
doaj   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Syn-CpG-Spacer: A Panel web app for synonymous recoding of viral genomes with CpG dinucleotides

<p>Syn-CpG-Spacer is a Progressive Web App (PWA) for biomedical scientists written in Python using Panel, Bokeh, Biopython libraries. It allows for synonymous recoding of genetic sequences to increase the frequency of CpG dinucleotides by setting ...
Sulkowski, Aleksander, Swanson, Chad, Bouton, Clément   +2 more
core   +1 more source

Defining the protein complement of CpG islands [PDF]

, 2011
In higher eukaryotes, the DNA base Cytosine can exist in a variety of modified forms when in the dinucleotide CpG. Although a methylated form tends to dominate within the genome, approximately 1% of all CpG dinucleotides are found unmodified at high ...
Thomson, John Paterson
core  

Correction to: Probabilistic estimation of hydraulic fracture half-lengths: validating the Gaussian pressure-transient method with the traditional rate transient analysis-method (Wolfcamp case study)

Journal of Petroleum Exploration and Production Technology, 2023
Dandi Alvayed, Mohammed Sofian Ali Khalid, Moaz Dafaalla, Ahmed Ali, Ahmed Farid Ibrahim, Ruud Weijermars   +5 more
doaj   +1 more source

Induction of Robust Immune Responses by CpG-ODN-Loaded Hollow Polymeric Nanoparticles for Antiviral and Vaccine Applications in Chickens

International Journal of Nanomedicine, 2020
Shu-Yi Lin,1 Bing-Yu Yao,2 Che-Ming Jack Hu,2,3 Hui-Wen Chen1,3 1Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan; 2Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; 3Research Center for Nanotechnology and ...
Lin SY, Yao BY, Hu CMJ, Chen HW
doaj  

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

A) Heatmap displaying the differential methylation pattern (with FDR < 0.05) and B) Circos plot representing the chromosome location of top 21 CpG sites (LS-CPG-WEKA) in early versus late stage of LIHC.

, 2019
A) Heatmap displaying the differential methylation pattern (with FDR < 0.05) and B) Circos plot representing the chromosome location of top 21 CpG sites (LS-CPG-WEKA) in early versus late stage of LIHC.
Sherry Bhalla (4886938), Harpreet Kaur (107427), Gajendra P. S. Raghava (7354226)   +2 more
core   +1 more source