Results 71 to 80 of about 196,785 (313)

A new approach to medical rehabilitation and palliative care for patients with oncology in the context of integrative medicine

Актуальные проблемы теоретической и клинической медицины
The systematic review summarizes modern studies of the effect of plant phenols and certain drugs on the intracellular biochemical cascade in the formation of anti-cancer immunity.
S. A. Panov, N. T. Baltabekov, A. V. Pavlyukov, A. A. Paltushev, B. E. Nurgaliev, A. V. Rysbaev   +5 more
doaj   +1 more source

The Association of Methylation Level in the CYP39A1 Gene with High Altitude Pulmonary Edema in the Chinese Population

Pharmacogenomics and Personalized Medicine, 2023
Pingyi Wang,1– 3 Hongyan Lu,1– 3 Hao Rong,1– 3 Yuhe Wang,1– 4 Li Wang,1– 3 Xue He,1– 3 Dongya Yuan,1– 3 Yongjun He,1– 3 Tianbo Jin1– 3 1Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region ...
Wang P, Lu H, Rong H, Wang Y, Wang L, He X, Yuan D, He Y, Jin T   +8 more
doaj  

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

The performance of stage classification hybrid models developed using 51 features (LS-CpG-RNA-hybrid) that comprise 21 CpG sites and 30 RNA transcripts.

, 2019
The performance of stage classification hybrid models developed using 51 features (LS-CpG-RNA-hybrid) that comprise 21 CpG sites and 30 RNA transcripts.
Sherry Bhalla (4886938), Harpreet Kaur (107427), Gajendra P. S. Raghava (7354226)   +2 more
core   +1 more source

Developing ground motion prediction models for West Java: A machine learning approach to support Indonesia's earthquake early warning system

Applied Computing and Geosciences
Indonesia, one of the most earthquake-prone countries in the world, is currently developing an Earthquake Early Warning (EEW) system. A key component of this system, the Regional EEW, relies on Ground Motion Prediction models (GMPMs) to issue end-user ...
Andy Rachmadan, Ardiansyah Koeshidayatullah, SanLinn I. Kaka   +2 more
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

The performance of different machine learning techniques-based stage classification models developed using 21 methylation CpG sites selected by WEKA (LS-CPG-WEKA).

, 2019
The performance of different machine learning techniques-based stage classification models developed using 21 methylation CpG sites selected by WEKA (LS-CPG-WEKA).
Sherry Bhalla (4886938), Harpreet Kaur (107427), Gajendra P. S. Raghava (7354226)   +2 more
core   +1 more source

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes

, 2009
Objective: to determine whether changes in the DNA methylation status in the promoter region of the gene encoding interleukin-1? (IL-1?) account for expression of IL1B mRNA after long-term treatment of human articular chondrocytes with inflammatory ...
Hashimoto, Ko, Gibson, Marc B., Helmtrud I. Roach, Mary B. Goldring, Richard O. C. Oreffo, Marc B. Gibson, Oreffo, Richard O.C., Roach, Helmstrud I., Goldring, Mary B., Ko Hashimoto   +9 more
core   +1 more source