Results 81 to 90 of about 318,338 (358)

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases

PLoS Genetics, 2012
The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA methylation patterns in a particular genome context is not well understood. Here, we describe a comprehensive analysis of DNA methylation patterns generated by high resolution sequencing of hairpin-bisulfite amplicons of selected single copy genes and repetitive ...
Arand, Julia, Spieler, David, Karius, Tommy, Branco, Miguel R., Meilinger, Daniela, Meissner, Alexander, Jenuwein, Thomas, Xu, Guoliang, Leonhardt, Heinrich, Wolf, Verena, Walter, Jörn   +10 more
openaire   +7 more sources

Asymmetry in Skipping Enhances Viability Against Control Input Noise

Advanced Robotics Research, EarlyView.
Quadruped animals use asymmetric galloping gaits at high speeds, yet the functional role of this asymmetry remains unclear. This study shows that left–right asymmetry in touchdown angles enhances robustness to control noise. Using a simple two‐legged locomotion model and viability theory, it demonstrates that asymmetric skipping substantially enlarges ...
Yuichi Ambe, Alvin So, Shinya Aoi
wiley   +1 more source

A new approach to medical rehabilitation and palliative care for patients with oncology in the context of integrative medicine

Актуальные проблемы теоретической и клинической медицины
The systematic review summarizes modern studies of the effect of plant phenols and certain drugs on the intracellular biochemical cascade in the formation of anti-cancer immunity.
S. A. Panov, N. T. Baltabekov, A. V. Pavlyukov, A. A. Paltushev, B. E. Nurgaliev, A. V. Rysbaev   +5 more
doaj   +1 more source

Genetic recombination is targeted towards gene promoter regions in dogs [PDF]

, 2013
The identification of the H3K4 trimethylase, PRDM9, as the gene responsible for recombination hotspot localization has provided considerable insight into the mechanisms by which recombination is initiated in mammals.
Adam Auton, Adam R Boyko, Carlos D Bustamante, J Kim Holloway, Jeffrey Kidd, Jessica J Hayward, John M Greally, Julie Nadel, Jun Wang, Jun Wang, Kyle Oliveira, Paula E Cohen, Ying Rui Li   +12 more
core   +4 more sources

ChicGrasp: Imitation‐Learning‐Based Customized Dual‐Jaw Gripper Control for Manipulation of Delicate, Irregular Bio‐Products

Advanced Robotics Research, EarlyView.
Automated poultry processing lines still rely on humans to lift slippery, easily bruised carcasses onto a shackle conveyor. Deformability, anatomical variance, and hygiene rules make conventional suction and scripted motions unreliable. We present ChicGrasp, an end‐to‐end hardware‐software co‐designed imitation learning framework, to offer a ...
Amirreza Davar, Zhengtong Xu, Siavash Mahmoudi, Pouya Sohrabipour, Chaitanya Pallerla, Yu She, Wan Shou, Philip Glen Crandall, Dongyi Wang   +8 more
wiley   +1 more source

Developing ground motion prediction models for West Java: A machine learning approach to support Indonesia's earthquake early warning system

Applied Computing and Geosciences
Indonesia, one of the most earthquake-prone countries in the world, is currently developing an Earthquake Early Warning (EEW) system. A key component of this system, the Regional EEW, relies on Ground Motion Prediction models (GMPMs) to issue end-user ...
Andy Rachmadan, Ardiansyah Koeshidayatullah, SanLinn I. Kaka   +2 more
doaj   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

CpG Oligodeoxynucleotide Developed to Activate Primate Immune Responses Promotes Antitumoral Effects in Combination with a Neoantigen-Based mRNA Cancer Vaccine

Drug Design, Development and Therapy, 2021
Qin Li,1,* Jie Ren,2,* Wei Liu,3 Guoqin Jiang,2 Rongkuan Hu1 1GenePharma Co., Ltd., Suzhou, 215125, Jiangsu, People’s Republic of China; 2Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215004,
Li Q, Ren J, Liu W, Jiang G, Hu R
doaj  

Pancancer analysis of DNA methylation-driven genes using MethylMix. [PDF]

, 2015
Aberrant DNA methylation is an important mechanism that contributes to oncogenesis. Yet, few algorithms exist that exploit this vast dataset to identify hypo- and hypermethylated genes in cancer.
Gevaert, Olivier, Plevritis, Sylvia K, Tibshirani, Robert   +2 more
core   +2 more sources