Results 121 to 130 of about 318,338 (358)

CpGFilter: CpG Filtering Method Based on Intra-Class Correlation Coefficients [PDF]

, 2014
Jun Chen
openalex   +1 more source

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Short-Term cost impact of compliance with clinical practice guidelines for initial sarcoma treatment [PDF]

Background: The impact of compliance to clinical practice guidelines (CPG) on outcomes and/or costs of care has not been completely clarified.Objective: To estimate relationships between medical expenditures and compliance to CPG for initial sarcoma ...
Anne-Valérie Decouvelaere, Antoine Lurkin, Christophe Bergeron, Dominic Cellier, Dominique Ranchère-Vince, François Gilly, Françoise Ducimetière, Guy De Laroche, Isabelle Ray-Coquard, Jean-Yves Blay, Lionel Perrier, Magali Morelle, Mathieu Laramas, Nathalie Havet, Nicola Cautela, Philippe Thiesse, Pierre Biron, Thierry Philip   +17 more
core  

Transcriptional memory emerges from cooperative histone modifications [PDF]

, 2011
Background Transcriptional regulation in cells makes use of diverse mechanisms to ensure that functional states can be maintained and adapted to variable environments; among them are chromatin-related mechanisms.
Hans Binder, Joerg Galle, Lydia Steiner, Sonja Prohaska, Thimo Rohlf   +4 more
core   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Additional file 6 of A core of differentially methylated CpG loci in gMDSCs isolated from neonatal and adult sources

, 2022
Isabella Berglund-Brown, Emily Nissen, Devin C. Koestler, Rondi A. Butler, Melissa Eliot, James F. Padbury, Lucas A. Salas, Annette M. Molinaro, Brock C. Christensen, John K. Wiencke, Karl T. Kelsey   +10 more
openalex   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

A kinematic and computational study of leech crawling: Support for a CPG based on travelling waves of excitation. [PDF]

, 2000
Many well characterized central pattern generators (CPGs) underlie behaviors (e.g., swimming, flight, heartbeat) that require regular rhythmicity and strict phase relationships.
Cacciatore, TW, Rozenshteyn, R, W, B
core  

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

A Ferritin-Based Eg95 Nanoparticle Vaccine Adjuvanted with pCpG Eliciting Robust Immune Responses Against Cystic Echinococcosis in Mice Model

International Journal of Nanomedicine
Xintao Gao,1,* Xizhou Zhu,2,* Xingjian Liu,1 Chenghao Zhou,1 Yuting Shang,1 Tong Wu,1 Hong Jia,3 Zhifang Zhang,1 Yinü Li,1 Ting Xin3 1National Key Laboratory of Agricultural Microbiology, Biotechnology Research Institute, Chinese Academy of ...
Gao X, Zhu X, Liu X, Zhou C, Shang Y, Wu T, Jia H, Zhang Z, Li Y, Xin T   +9 more
doaj