Results 121 to 130 of about 196,785 (313)

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Genetic and epigenetic analyses of MBD3 in colon and lung cancer

, 2004
MBD3: is a member of the methyl-CpG-binding domain family and is located on chromosome 19p13.3, a region of loss of heterozygosity in colon and lung cancers. We therefore screened samples for abnormalities in MBD3. Our results indicate that MBD3 is not a
Bader, S A, S A Bader, D J Harrison, Y Zhu, Sa Bader, Harrison, D J, Dj Harrison, Zhu, Y   +7 more
core   +1 more source

Biomarkers of Sarcopenia: Current Status and Future Perspectives

AGING MEDICINE, EarlyView.
In this review, we summarize the various biomarkers discovered in recent years, including biochemical, imaging, and physical testing markers. We analyze their advantages and disadvantages and propose potential ways to improve the diagnostic accuracy of biomarkers, as well as future research directions.
Bijin Luo, Wenhan Li, Yi Zhang, Mengchen Liu, Kemeng Zhang, Sui Huang, Ping He   +6 more
wiley   +1 more source

CpG-C treatment results in elevated in vivo expression of apoptosis-inducing, phagocytosis-related, and inflammatory factors.

, 2019
(a) CX3CR1GFP/+ mice were injected with CpG-C or vehicle, and 24 hours later mRNA expression levels in sorted microglia cells were quantified using RT-qPCR.
Amit Benbenishty (6524375), Neta Erez (6524393), Lior Mayo (2732314), David Kain (3366914), Ariella Glasner (322911), Azzurra Cottarelli (6524381), Dritan Agalliu (238515), Meital Gadrich (6524378), Malak Amer (6524387), Shamgar Ben-Eliyahu (222574), Alisa Lubart (6524384), Lee Shaashua (6524390), Pablo Blinder (269181)   +12 more
core   +1 more source

Parametric Analysis of Spiking Neurons in 16 nm Fin Field‐Effect Transistor Technology

Advanced Intelligent Discovery, EarlyView.
Energy efficient computing has driven a shift toward brain‐inspired neuromorphic hardware. This study explores the design of three distinct silicon neuron topologies implemented in 16 nm fin field‐Effect transistor technology. While the Axon‐Hillock design achieves gigahertz throughput, its functional fragility persists. The Morris–Lecar model captures
Logan Larsh, Raiyan Siddique, Sarah S. Sharif, Yaser Mike Banad   +3 more
wiley   +1 more source

Evaluating poro-elastic production drive mechanisms: Quantifying the potential contribution to well-rates and risk of core handling damage inflating pore-volume compressibility measurements

Energy Geoscience
By analyzing core data from an offshore Gulf of Mexico reservoir and developing analytical solutions, it can be demonstrated that laboratory measurements on pore-volume compressibility include artifacts, leading to a misinterpretation of porosity and ...
Ruud Weijermars
doaj   +1 more source

3D‐Printed Shark‐Inspired Soft–Hard Hybrid Underwater Robot With Buoyancy Control and Onboard Vision

Advanced Intelligent Systems, EarlyView.
A fully self‐contained shark‐inspired underwater robot is developed using 3D‐printed soft–hard hybrid structures, servo‐driven propulsion, and pump‐based buoyancy control. The platform achieves three‐dimensional locomotion and onboard vision‐based target tracking, offering a reproducible and accessible framework for biomimetic underwater robot research.
Shotaro Saito, Byeongwook Jo, Minghao Nie, Shoji Takeuchi   +3 more
wiley   +1 more source

Automatic seismic fault detection and surface construction

Applied Computing and Geosciences
This paper proposes an effective approach for automatically building the fault model based on the 3D seismic images via two steps of automatic seismic fault detection and fault surface construction.
Xin Liu, Xingyu Zhu, Xupeng He, Yuzhu Wang   +3 more
doaj   +1 more source

The IL‐10/IL‐6 Ratio and the Risk Score: Two Cytokines‐Based Predictors for Malignancy‐Associated Hemophagocytic Lymphohistiocytosis in Adults (M‐HLHa)

American Journal of Hematology, EarlyView.
ABSTRACT The predictive value of cytokines (CK) for malignancy‐associated adult hemophagocytic lymphohistiocytosis (M‐HLHa) remains uncertain. We evaluated a cytokine‐based Risk Score (RS) and the IL‐10/IL‐6 Ratio to predict M‐HLHa. Adult patients (n = 112) from the French HLH cohort (NCT02113917) with complete data for nine key HLH related CK measured
Coralie Bloch, Stephanie Chhun, Nanthara Sritharan, Marine Gil, Raphael Lhote, Marouane Boubaya, Olivier Lambotte, David Launay, Claire Larroche, Estibaliz Lazaro, Francois Liffermann, Marc Michel, Jean‐Marie Michot, Pierre Morel, Louis Terriou, Geoffrey Urbansk, Jean‐Francois Viallard, Morgane Cheminant, Felipe Suarez, Yves Lepelletier, Geneviève de Saint Basile, Olivier Hermine, the French HLH Study Group, Coralie Bloch, Jean Philippe Jais, Francois Liffermann, Pierre Morel, Morgane Cheminant, Felipe Suarez, Olivier Hermine, Fabrice Bonnet, Pascal Godemer, Damaj Gandhi, Olivier Fain, Olivier Lambotte, David Launay, Louis Terriou, Claire Larroche, Estibaliz Lazaro, Jean‐Francois Viallard, Francois Liffermann, Olivier Lortholary, Marc Michel, Jean‐Marie Michot, Pierre Morel, Frederic Pene, Antoinette Perlat, Geoffrey Urbanski   +47 more
wiley   +1 more source

Production optimization in shale formations: Focus on proppant delivery schedules and mitigation of fracture conductivity damage

Petroleum
This study presents recent advances in modeling capacity and provides optimization guidelines for key operational parameters controlling well performance, using real well data.
Ruud Weijermars
doaj   +1 more source