Results 141 to 150 of about 155,959 (265)

Epigenetic Aging in Brain Tissue of the Self-Fertilizing Vertebrate, <i>Kryptolebias marmoratus</i>. [PDF]

Ecol Evol
Bélik J, Silvestre F.
europepmc   +1 more source

Fluorogenic Sydnones for Bioorthogonal Labeling of DNA

Chemistry – A European Journal, EarlyView.
Conjugates of sydnones with cyanine‐styryl dyes combine bioorthogonal reactivity with fluorogenicity. The reactivity with bicyclo[6.1.0]non‐4‐yne (BCN)‐modified DNA showed second‐order rate constants of up to k2 = 2,300 M−1s−1 and fluorescence turn‐on by one magnitude of order.
Kerstin Müller, Hans‐Achim Wagenknecht   +1 more
wiley   +1 more source

CpG 1018 augments mRNA vaccine-induced anti-tumor immunity by potentiating CD8+ T cell responses. [PDF]

Mol Ther Oncol
Li Y, Nakkala JR, Akter L, Kang X, Song Y, VanLuinen E, Chen X.   +6 more
europepmc   +1 more source

4′‐ThioRNA Substitution and Sense‐Strand Segmentation for the Design of Functional Fully Modified siRNAs Targeting SARS‐CoV‐2

Chemistry – A European Journal, EarlyView.
4′‐ThioRNA was broadly tolerated across multiple positions in SARS‐CoV‐2‐targeting siRNAs, but full 4'‐thio modification of both strands caused a reduction in RNAi activity. Sense‐strand segmentation improved RNAi and antiviral activity, particularly when the nick was located at position 10 from the 5′‐end of the sense strand, thereby unlocking the ...
Yuhei Nogi, Jun Tsukimoto, Noriko Saito‐Tarashima, Takaaki Koma, Masako Nomaguchi, Noriaki Minakawa   +5 more
wiley   +1 more source

<i>NOS1</i> hypermethylation may participate in the colorectal cancer development and be associated with its prognosis. [PDF]

Epigenetics
Zhang Z, Yeerken A, Shao X, Qian S, Lin S, Gu S, Ying X, Li Z, Fei X, Yang J, Tang M, Wang J, Jin M, Chen K.   +13 more
europepmc   +1 more source

Modulation of Epigenetic Control by Advanced Molecular Tweezers

Chemistry – A European Journal, EarlyView.
Tailored dimeric molecular tweezers recognize the DNA‐binding part of Histone H4 and interrupt the essential histone‐DNA interaction. ABSTRACT This work addresses the question if supramolecular systems can be tailored to interfere with posttranslational modifications (PTM) and epigenetics.
My‐Hue‐Le, Bianca Kamba, Anja Matena, Christine Beuck, Victoria Momand, Spiros Salvanos, Jessica Vossen, Mike Blueggel, Thomas Schrader, Peter Bayer   +9 more
wiley   +1 more source

Ensuring Clinical Practice Guidelines Meet the Needs of the End-User: a Prioritization Survey for Guideline Topics for Behavioural and Psychological Symptoms of Dementia. [PDF]

Can Geriatr J
Atchison K, Watt JA, Porter J, Seitz D, Kirkham J, Goodarzi Z.   +5 more
europepmc   +1 more source

CpG islands [PDF]

Genome Biology, 2002
openaire   +1 more source

Spectral, Semi‐Spectral, and Bandwidth Flow Cytometric Implementation of Multiplex Cytokine Bead Assays

Cytometry Part A, EarlyView.
ABSTRACT Multiplex cytokine bead assays (MCBA) have previously been carried out on conventional (aka classical, or bandwidth) flow cytometers, and issues involving unmixing distortions were encountered when using the manufacturer's set‐up beads for unmixing full‐spectrum data.
Jacob Laster, Jenny Hernandez‐Davies, D. Huw Davies, Egest J. Pone   +3 more
wiley   +1 more source

Vipr2 Gene Expression Is Upregulated in the Nucleus Accumbens of Spontaneous Hypertensive Rats During Early Life. [PDF]

Neuropsychopharmacol Rep
Araki R, Kita A, Ago Y, Yabe T.
europepmc   +1 more source