Results 161 to 170 of about 155,959 (265)

DNA Methylation and Transcriptomic Profiles of Wilms Tumour Reveal New Deregulated Genes and Epigenetic Processes Relevant for Tumour Stratification and Management

International Journal of Cancer, EarlyView.
ABSTRACT Wilms Tumour (WT), the most common kidney cancer in children, presents features of altered kidney development and frequently exhibits molecular alterations at the 11p15.5 imprinted locus, affecting the IGF2 and H19 genes, which contribute to tumour growth and predisposition.
Abu Saadat, Francesco Cecere, Federica Rossetti, Laura Pignata, Emilia D'Angelo, Carlo Giaccari, Gaetano Verde, Paola Quarello, Franca Fagioli, Josep Roma, Manel Esteller, Enrique de Álava, Flavia Cerrato, Andrea Riccio, Angela Sparago   +14 more
wiley   +1 more source

Sex-based considerations in the choice for a TLR9 or TLR7/8 agonist to arm the sentinel lymph node in early-stage melanoma. [PDF]

Oncoimmunology
Notohardjo JCL, Toffoli EC, Muijlwijk T, van den Hout MFCM, Kandiah V, Labots M, van de Ven R, van den Eertwegh AJM, de Gruijl TD.   +8 more
europepmc   +1 more source

Cross‐Regulation Between DNA Methylation and Circadian Clock Reprogramming in Ovarian Cancer: Mechanistic Insights, Biomarker Potential, and Therapeutic Implications

International Journal of Cancer, EarlyView.
ABSTRACT Early diagnosis remains challenging, recurrence rates remain high, and platinum resistance frequently develops in ovarian cancer (OC), collectively representing major barriers to long‐term patient survival. DNA methylation (DNAm), as a relatively stable yet dynamically modifiable epigenetic signature, can capture alterations in tumor states ...
Min Xing, Chang Zhou, Yi Tang, Shuhui Xu, Shasha Zhou, Weiai Liu, Huiping Liu   +6 more
wiley   +1 more source

An extrinsic enzyme-activatable fluorescent probe for high-contrast tumor imaging. [PDF]

Chem Sci
Guo Y, Du Y, Heng L, Miao H, Chen C, Zhang Q, Wang J, Shan Y, Chen Z, Li L.   +9 more
europepmc   +1 more source

Maternal overweight and obesity during pregnancy and sex‐dependent dysregulation of the materno‐fetal stress axis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Maternal obesity and excess gestational weight gain (GWG) are linked to adverse perinatal outcomes, potentially via disruption of the maternal–fetal stress axis. Placental HSD11B2 protects the fetus from excess glucocorticoids and may influence fetal programming during maternal metabolic stress.
Thorsten Braun, Marie Hofmann, Rebecca Rancourt, Julia Sommer, Alexandra Kühn, Loreen Ehrlich, Thomas Ziska, Kerstin Melchior, Karen Schellong, Wolfgang Henrich, Sonja Entringer, Katherine Margaret Kennedy, Andreas Plagemann, Deborah Magdalena Sloboda   +13 more
wiley   +1 more source

Epigenetic landscapes in human pancreatic islets reveal distinct drivers for adaptation to age and type 2 diabetes. [PDF]

Nat Commun
Maurin L, Marselli L, Boissel M, Pascat V, Suleiman M, Henriques E, De Luca C, Ning L, Fourcot M, Tesi M, Toussaint B, Amanzougarene S, Derhourhi M, Oger F, Burdet F, Canouil M, Cnop M, Ibberson M, Bonnefond A, Marchetti P, Froguel P, Khamis A.   +21 more
europepmc   +1 more source

Chromosome‐level genome and methylome of vine tea suggest roles for tandem duplication and CHH hypomethylation in high dihydromyricetin accumulation

iMetaOmics, EarlyView.
A chromosome‐level genome assembly and single‐base resolution methylome of vine tea (Nekemias grossedentata) reveal that lineage‐specific tandem duplications of dihydromyricetin (DHM) biosynthetic genes (NgCHS and NgF3′5′ H) have expanded their copy numbers, providing the genetic basis for high DHM flux.
Yingmei Wu, Hanrui Hu, Qing Ye, Xueqing Chen, Miyuan Tian, Jing Li, Li Lu, Yifei Liu, Yi Shang, Yanling Li, Xingyao Xiong, Junbo Gou   +11 more
wiley   +1 more source

DNA Methylation Variation in Blood Cells may Impact Platelet Function. [PDF]

TH Open
Teichman J, Chen MH, Thibord F, Chan MV, Nkambule BB, Lachapelle AR, Ma J, Joehanes R, Liu C, Aponte AM, Panicker SR, Kanthi Y, Levy D, Johnson AD.   +13 more
europepmc   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Covalent conjugation of TLR9 agonists to phospholipids enhances mRNA-LNP delivery efficiency and dendritic cell cross-priming. [PDF]

J Nanobiotechnology
Ji W, Zhu K, Zhou Y, Yan H, Wei J, Zhu Y, Li S, Hong Y, Dai J, Dong S, Hu H, You J, Qiu Y, Lou Y.   +13 more
europepmc   +1 more source