Results 151 to 160 of about 196,785 (313)

Structure-dependent immunostimulatory effect of CpG oligodeoxynucleotides and their delivery system

, 2012
Nobutaka HanagataNanotechnology Innovation Station, National Institute for Materials Science, Tsukuba, Ibaraki, and Graduate School of Life Science, Hokkaido University, Kita-ku, Sapporo, JapanAbstract: Unmethylated cytosine-phosphate-guanosine (CpG ...
Hanagata N
core  

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source

A Study Of Vertebrate CpG-islands-associated miRNA Genes

, 2009
[[abstract]]MicroRNAs(MIRNAs)are about 22 nucleotides small regulatory RNAs, which produced from hairpin-like precursors, and suppressing translation of target genes by binding to mRNA. MicroRNAs perform the role of gene regulation.
Jheng Shu Ping
core  

N‐Aryl Acridone Derivatives as Effective Catalysts for Energy Transfer Reactions

Chemistry – A European Journal, EarlyView.
Acridones derivatives have high triplet energy, are simple accessible, and could be used in challenging [2+2] ENT reactions. ABSTRACT Organic photocatalysts capable of promoting high‐energy triplet energy transfer (EnT) remain limited, particularly for demanding [2+2] photocycloaddition reactions.
Francesco Calogero, Gaetano D'Onghia, Federica Fina, Zakaria Ziani, Luca Sensoli, Andrea Gualandi, Andrea Fermi, Paola Ceroni, Pier Giorgio Cozzi   +8 more
wiley   +1 more source

Resolução Normativa 01/2019/CPG

, 2019
regulamenta os estágios não obrigatórios no âmbito da Pós-Graduação da ...
CPG, UFSC
core  

Haplotype-resolved DNA methylation at the <i>APOE</i> locus identifies allele-specific epigenetic signatures relevant to Alzheimer's disease risk. [PDF]

NPJ Dement
Genner RM, Meredith M, Daida K, Moller A, Weller C, Ayuketah A, Jerez PA, Akeson S, Malik L, Baker B, Kouam C, Paquette K, Catching A, Bromberek S, Hu F, Reed X, Marenco S, Auluck P, Mandal A, Paten B, Gibbs JR, Jain M, Cookson MR, Singleton AB, Nalls M, Blauwendraat C, Billingsley KJ.   +26 more
europepmc   +1 more source

Synergistic Action of Ascorbic Acid and Readily Accessible NHC^N Ligands for the Oxidation of Gold(I) With Electron‐Rich Aryldiazonium Salts

Chemistry – A European Journal, EarlyView.
The synergic action of ascorbic acid and NHC^N ligands enables Au(I) oxidation with electron‐rich aryldiazonium salts. ABSTRACT The synergistic action of ascorbic acid and NHC^N ligands enables the challenging oxidation of Au(I) with electron‐rich aryldiazonium salts in the absence of a cocatalyst and/or irradiation. EPR, NMR, and x‐ray analyses reveal
Paula G. Cárdenas‐Cárdenas, Diego Dusso, Saúl Soto‐Zúñiga, Osvaldo F. López‐Saladino, Simón Hernández‐Ortega, Rubén A. Toscano, Virginia Gómez‐Vidales, Susana Porcel‐García   +7 more
wiley   +1 more source

Influence of High-Volume Calcined Phosphogypsum on Mechanical Properties and Freeze-Thaw Resistance of Supersulfated Slag Cement Concrete. [PDF]

Materials (Basel)
Deng F, Han G, Xu K, Jia X, Zheng D, Tao L, Dong J, Liao Y.   +7 more
europepmc   +1 more source

Synthesis of Oligonucleotide Conjugates Employing a Diselenide Linker

Chemistry – A European Journal, EarlyView.
ABSTRACT In this study, we report the synthesis of an alkylene linker containing a terminal 2‐cyanoethyl protected selenium functionality for coupling at the 5'‐end of an oligonucleotide by solid phase synthesis for the preparation of oligonucleotide conjugates.
Shivam Tikoo, Anne M. Noronha, Christopher J. Wilds   +2 more
wiley   +1 more source