Results 151 to 160 of about 155,959 (265)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Metabolic Tagging of Tumour Extracellular Vesicles for Targeted Modulation of Dendritic Cells. [PDF]

J Extracell Vesicles
Bhatta R, Xu W, Dai R, Liu Y, Zhou J, Xue Y, Wang H.   +6 more
europepmc   +1 more source

Suppressive CpG [PDF]

The Journal of Experimental Medicine, 2005
openaire   +1 more source

Heterogeneous Exhumation Mechanisms in Neoproterozoic Collisional Metamorphism: P–T Constraints From Pelotas and Punta del Este Terranes, Southern Brazil and Uruguay

Geological Journal, EarlyView.
Petrography, thermobarometry, and pseudosection modelling reveal peak metamorphic conditions of 3–7.5 kbar and 520°C–800°C in Tonian‐Cryogenian orthogneisses of the Dom Feliciano Belt. Metamorphic field gradients of 27°C/km–39°C/km and variable exhumation mechanisms support correlation of these units as remnants of a Himalayan‐type Piratini Orogeny ...
Thaiane Niederauer‐Santos, Carla Cristine Porcher, Daniel Triboli Vieira, Edinei Koester, Diego Jaldín, Karina Luengo, Luisa Caon   +6 more
wiley   +1 more source

Rising Incidence and Mortality of Colorectal Cancer Among Younger Adults: A Population‐Based Study in Taiwan, 1994–2018

International Journal of Cancer, EarlyView.
Colorectal cancer incidence and mortality have increased in the Asia‐Pacific region over the past three decades. This population‐based study in Taiwan suggests a shift of the colorectal cancer burden towards the younger generations. An age–period–cohort model revealed higher annual increases in incidence (3.58%) and mortality (1.0%) rates among ...
Yun‐Chen Tsai, Chih‐Yi Wu, Tsung‐I Hung, Hung‐Yi Chiou   +3 more
wiley   +1 more source

Clinical practice guidelines: Important tools to teach the art of medicine. [PDF]

Can Fam Physician
McCabe J.
europepmc   +1 more source

Epigenetic Markers of Cell Division and Ageing in Relation to Breast Cancer Survival

International Journal of Cancer, EarlyView.
ABSTRACT Breast cancer remains a major challenge to public health. Biomarkers may be useful to improve prediction of breast cancer survival. Several epigenetic markers of cell division and ageing based on DNA methylation have been proposed. In this study, we measured these epigenetic markers in breast tumours and assessed their prognostic value.
Luca Li, Elaheh Zarean, Danmeng Lily Li, Yiyue Zhu, Shuai Li, Enes Makalic, Catriona McLean, Graham G. Giles, Roger L. Milne, Melissa C. Southey, Pierre‐Antoine Dugué   +10 more
wiley   +1 more source

Epigenome-wide association study of psilocybin-induced methylome changes in alcohol use disorder. [PDF]

Transl Psychiatry
Urban MM, Zillich L, Rieser NM, Herdener M, Spanagel R, Vollenweider FX, Preller KH, Meinhardt MW.   +7 more
europepmc   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, EarlyView.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Integrative multi-cohort analysis of DNA methylation profiles for pancreatic ductal adenocarcinoma biomarker discovery and prognosis. [PDF]

Front Bioinform
Inayat H, Aazam M.
europepmc   +1 more source