Results 171 to 180 of about 155,959 (265)

CpG receptors [PDF]

Genome Biology, 2001
openaire   +1 more source

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

Putative Imprinting Control Regions with Aberrant Blood-Based DNA Methylation are Associated with Hepatocellular Carcinoma Risk. [PDF]

J Hepatocell Carcinoma
DiFrank AJ, Corliss BA, Park JJH, Rogers M, Skaar DA, Jima DD, Cowley M, Murphy SK, Liu A, Moylan CA, Hoyo C.   +10 more
europepmc   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, EarlyView.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

Low Depth Epigenetic Mapping of Maturation Versus Retrodifferentiation in HepaRG Cells. [PDF]

Epigenomes
Hernandez-Vargas H, Petitjean K, Lambert MP, Daniel Y, Chemin I, Corlu A, Goldsmith C.   +6 more
europepmc   +1 more source

Epigenetically Regulated NOX4/NRF2 Axis Mediates PM2.5‐Induced Ferroptosis and Inflammatory Response in Membranous Nephropathy

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aims to explore the involvement and mechanism of ferroptosis in particulate matter 2.5 (PM2.5)–induced membranous nephropathy (MN) progression. A cationic bovine serum albumin (cBSA)–induced mouse model of MN was established, followed by PM2.5 exposure.
Yanhong Gao, Yinfeng Guo, Shaoyan Xu, Min Zhang, Yanxia Rui, Shujun Pan, Changhua Zhou, Jianxiang Chen, Henglan Wu   +8 more
wiley   +1 more source

A DNA Methylation Signature Predicts Survival and Platinum Response in HNSCC. [PDF]

Laryngoscope Investig Otolaryngol
Chhabra R, Kao A, Mokhashi O, Li WT, John D, Wang-Rodriguez J, Ongkeko WM.   +6 more
europepmc   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

Characterizing cytosine methylation of polymorphic transposable element insertions using the human pangenome resources. [PDF]

Genome Res
Zhuo X, Tomlinson C, Belter EA, Kuntala PK, Saintilnord WN, Jiang J, Lindsay T, Macias-Velasco JF, Fulton RS, Wang T, Human Pangenome Reference Consortium.   +10 more
europepmc   +1 more source

The Landscape of Biomarkers in ICU‐Associated AKI: From Protein Markers to Cell‐Free Nucleic Acids

Journal of Clinical Laboratory Analysis, EarlyView.
Acute kidney injury (AKI) in critically ill patients—particularly in sepsis—often develops early and is missed by creatinine/urine output–based criteria, delaying risk stratification and timely intervention. This review synthesizes current evidence on established and emerging AKI biomarkers (e.g., NGAL, KIM‐1, [TIMP‐2]·[IGFBP7]) alongside circulating ...
Qi Zhu, Feng Yang, Hua Zheng, Xinxin Guo, Zhijin Chen, Limin Chen, Daoli Wang, Jiaqi Wang, Xinmeng Wang, Zhiyuan Huang, Zhenhua Ji   +10 more
wiley   +1 more source