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Methylation Analysis of CpG Islands
2003The application of Southern blotting to determine the methylation status of a particular gene has already been alluded to in Chapter 17 by Tennant et al., and methodology for Southern blotting described. This chapter examines methylation analysis of CpG islands in more depth and describes a technique by which quantitative changes may be monitored with ...
R, Lilischkis, H, Kneitz, H, Kreipe
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CpG Islands: A Historical Perspective
2018The discovery of CpG islands (CGIs) and the study of their structure and properties run parallel to the development of molecular biology in the last two decades of the twentieth century and to the development of high-throughput genomic technologies at the turn of the millennium.
Francisco, Antequera, Adrian, Bird
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CpG islands: their potential as biomarkers for cancer
Expert Review of Molecular Diagnostics, 2007In general, DNA methylation acts in concert with other epigenetic processes, including histone modifications, chromatin remodeling and microRNAs, to shape the overall chromatin structure of the nucleus and potentially modify its functional state. Aberrant DNA methylation events can occur in a number of human diseases but we are only just beginning to ...
Huidong, Shi +2 more
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CpG islands of chicken are concentrated on microchromosomes
Nature Genetics, 1996The chicken karyotype comprises 39 chromosome pairs of which at least 29 are 'microchromosomes'. Microchromosomes account for about 25% of the genomic DNA, but they are cytologically indistinguishable from one another (1). Due to technical limitations there is a strong bias of mapped genes within the chicken genome database ChickGBASE (2) towards ...
H A, McQueen +5 more
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Demethylation of CpG islands in embryonic cells
Nature, 1991DNA in differentiated somatic cells has a fixed pattern of methylation, which is faithfully copied after replication. By contrast, the methylation patterns of many tissue-specific and some housekeeping genes are altered during normal development.
D, Frank +5 more
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2017
This is an introductory bioinformatics exercise intended for use in a genetics course.
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This is an introductory bioinformatics exercise intended for use in a genetics course.
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CpG island methylator phenotype in cancer
Nature Reviews Cancer, 2004DNA hypermethylation in CpG-rich promoters is now recognized as a common feature of human neoplasia. However, the pathophysiology of hyper-methylation (why, when, where) remains obscure. Cancers can be classified according to their degree of methylation, and those cancers with high degrees of methylation (the CpG island methylator phenotype, or CIMP ...
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