Results 211 to 220 of about 487,995 (250)

CpG Islands in vertebrate genomes

Journal of Molecular Biology, 1987
Although vertebrate DNA is generally depleted in the dinucleotide CpG, it has recently been shown that some vertebrate genes contain CpG islands, regions of DNA with a high G+C content and a high frequency of CpG dinucleotides relative to the bulk genome.
M, Gardiner-Garden, M, Frommer
exaly   +3 more sources

CpG islands and genes

Current Opinion in Genetics & Development, 1995
Of the estimated 45,000 CpG islands in the human genome, the overwhelming majority are found at the 5' ends of genes and their identification and cloning are proving very useful for finding and isolating genes. Recent work has shed light on the chromosomal distribution and origin of CpG islands.
S H, Cross, A P, Bird
openaire   +2 more sources

Epigenomics: beyond CpG islands

Nature Reviews Genetics, 2004
Epigenomic studies aim to define the location and nature of the genomic sequences that are epigenetically modified. Much progress has been made towards whole-genome epigenetic profiling using molecular techniques, but the analysis of such large and complex data sets is far from trivial given the correlated nature of sequence and functional ...
Melissa J, Fazzari, John M, Greally
openaire   +2 more sources

Methylation Analysis of CpG Islands

2003
The application of Southern blotting to determine the methylation status of a particular gene has already been alluded to in Chapter 17 by Tennant et al., and methodology for Southern blotting described. This chapter examines methylation analysis of CpG islands in more depth and describes a technique by which quantitative changes may be monitored with ...
R, Lilischkis, H, Kneitz, H, Kreipe
openaire   +2 more sources

CpG Islands in Human X‐Inactivation

Annals of Human Genetics, 2003
SummarySequence comparison analyses have been carried out for 19 genes escaping X‐inactivation versus 73 genes subject to X‐inactivation, and 100 randomly chosen X chromosome genes versus 100 randomly chosen autosomal genes. The coding sequence of the genes and their upstream and downstream flanking sequences were investigated using a series of windows
Ke, X., Collins, A.
openaire   +4 more sources

CpG Islands: A Historical Perspective

2018
The discovery of CpG islands (CGIs) and the study of their structure and properties run parallel to the development of molecular biology in the last two decades of the twentieth century and to the development of high-throughput genomic technologies at the turn of the millennium.
Francisco, Antequera, Adrian, Bird
openaire   +2 more sources

Demethylation of CpG islands in embryonic cells

Nature, 1991
DNA in differentiated somatic cells has a fixed pattern of methylation, which is faithfully copied after replication. By contrast, the methylation patterns of many tissue-specific and some housekeeping genes are altered during normal development.
D, Frank, I, Keshet, M, Shani, A, Levine, A, Razin, H, Cedar   +5 more
openaire   +2 more sources

CpG island methylator phenotype in cancer

Nature Reviews Cancer, 2004
DNA hypermethylation in CpG-rich promoters is now recognized as a common feature of human neoplasia. However, the pathophysiology of hyper-methylation (why, when, where) remains obscure. Cancers can be classified according to their degree of methylation, and those cancers with high degrees of methylation (the CpG island methylator phenotype, or CIMP ...
openaire   +2 more sources

Bioinformatics: CpG Islands

2017
This is an introductory bioinformatics exercise intended for use in a genetics course.
openaire   +1 more source

CpG Islands

1993
F, Antequera, A, Bird
openaire   +2 more sources