Results 21 to 30 of about 4,376,271 (343)
Zeitschrift für Induktive Abstammungs- und Vererbungslehre, 2010 K. Archer, V. Mas, D. Maluf, R. Fisher
semanticscholar +3 more sources
CpG site DNA methylation patterns reveal a novel regulatory element in the mouse prion protein gene. [PDF]
J Vet Med Sci, 2017 Dalai W +4 more
europepmc +3 more sources
CpG Methylation in Aging: Trajectories of Individual Sites [PDF]
Innovation in Aging, 2020 Abstract Age-related changes in methylation in a set of genomic CpGs have been shown to form a kind of molecular clocks of aging – DNA methylation (DNAm) clocks. These markers are usually based on a small set of CpGs in every case, but 1) they rarely overlap between different clocks and 2) they are interchangeable, meaning that one can ...
Margarita Meer, Morgan E. Levine
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In silico identification of single nucleotide variations at CpG sites regulating CpG island existence and size [PDF]
Scientific Reports, 2022 AbstractGenetic and epigenetic modifications of genes involved in the key regulatory pathways play a significant role in the pathophysiology and progression of multifactorial diseases. The present study is an attempt to identify single nucleotide variations (SNVs) at CpG sites of promoters of ACAT1, APOB, APOE, CYBA, FAS, FLT1, KSR2, LDLR, MMP9, PCSK9,
Nivas Shyamala +6 more
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Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation?
Epigenetics, 2022 Lifestyle-related phenotypes have been shown to be heritable and associated with DNA methylation. We aimed to investigate whether genetic predisposition to tobacco smoking, alcohol consumption, and higher body mass index (BMI) moderates the effect of ...
Chenglong Yu +13 more
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Identifying fenofibrate responsive CpG sites [PDF]
BMC Proceedings, 2018 As part of GAW20, we analyzed the familiality and variability of methylation to identify cytosine-phosphate-guanine (CpG) sites responsive to treatment with fenofibrate. Methylation was measured at approximately 450,000 sites in pedigree members, prior to and after 3 weeks of treatment.
Calvin Pan +2 more
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Epigenetic inheritance is unfaithful at intermediately methylated CpG sites
Nature Communications, 2023 AbstractDNA methylation at the CpG dinucleotide is considered a stable epigenetic mark due to its presumed long-term inheritance through clonal expansion. Here, we perform high-throughput bisulfite sequencing on clonally derived somatic cell lines to quantitatively measure methylation inheritance at the nucleotide level.
Hay, Amir D +6 more
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Inheritance of an epigenetic mark: the CpG DNA methyltransferase 1 is required for de novo establishment of a complex pattern of non-CpG methylation. [PDF]
PLoS ONE, 2007 Site-specific methylation of cytosines is a key epigenetic mark of vertebrate DNA. While a majority of the methylated residues are in the symmetrical (meC)pG:Gp(meC) configuration, a smaller, but significant fraction is found in the CpA, CpT and CpC ...
Valérie Grandjean +3 more
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Collaborations between CpG sites in DNA methylation [PDF]
International Journal of Modern Physics B, 2017 DNA methylation patterns have profound impacts on genome stability, gene expression, and development. The molecular base of DNA methylation patterns has long been focused at single CpG sites level. Here, we construct a kinetic model of DNA methylation with collaborations between CpG sites, from which a correlation function was established based on ...
Song, You, Ren, Honglei, Lei, Jinzhi
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Scientific Reports, 2021 Genome-wide DNA methylation profiling have been used to find maternal CpG sites related to the occurrence of gestational diabetes mellitus (GDM). However, none of these differential sites found has been verified in a larger sample.
Xiaolei Wang +10 more
doaj +1 more source