Results 21 to 30 of about 164,158 (344)

Identifying fenofibrate responsive CpG sites [PDF]

BMC Proceedings, 2018
As part of GAW20, we analyzed the familiality and variability of methylation to identify cytosine-phosphate-guanine (CpG) sites responsive to treatment with fenofibrate. Methylation was measured at approximately 450,000 sites in pedigree members, prior to and after 3 weeks of treatment.
Rita Cantor, Linda Navarro, Calvin Pan
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Inheritance of an epigenetic mark: the CpG DNA methyltransferase 1 is required for de novo establishment of a complex pattern of non-CpG methylation. [PDF]

PLoS ONE, 2007
Site-specific methylation of cytosines is a key epigenetic mark of vertebrate DNA. While a majority of the methylated residues are in the symmetrical (meC)pG:Gp(meC) configuration, a smaller, but significant fraction is found in the CpA, CpT and CpC ...
Valérie Grandjean, Ruken Yaman, François Cuzin, Minoo Rassoulzadegan   +3 more
doaj   +1 more source

Epigenetic inheritance is unfaithful at intermediately methylated CpG sites

Nature Communications, 2023
AbstractDNA methylation at the CpG dinucleotide is considered a stable epigenetic mark due to its presumed long-term inheritance through clonal expansion. Here, we perform high-throughput bisulfite sequencing on clonally derived somatic cell lines to quantitatively measure methylation inheritance at the nucleotide level.
Hay, Amir D, Kessler, Noah J, Gebert, Daniel, Takahashi, Nozomi, Tavares, Hugo, Teixeira, Felipe K, Ferguson-Smith, Anne C   +6 more
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Study on the relationship between DNA methylation of target CpG sites in peripheral blood and gestational diabetes during early pregnancy

Scientific Reports, 2021
Genome-wide DNA methylation profiling have been used to find maternal CpG sites related to the occurrence of gestational diabetes mellitus (GDM). However, none of these differential sites found has been verified in a larger sample.
Xiaolei Wang, Jin Huang, Yixiang Zheng, Sisi Long, Huijun Lin, Na Zhang, Mengyuan Tian, Xinrui Wu, Rongjing An, Shujuan Ma, Hongzhuan Tan   +10 more
doaj   +1 more source

CpG Sites Preferentially Methylated by Dnmt3a in Vivo [PDF]

Journal of Biological Chemistry, 2006
Dnmt3a and Dnmt3b are two major de novo DNA methyltransferases essential for embryonic development in mammals. It has been shown that Dnmt3a and Dnmt3b have distinct substrate preferences for certain genomic loci, including major and minor satellite repeats.
Masahiro, Oka, Nemanja, Rodić, Jamie, Graddy, Lung-Ji, Chang, Naohiro, Terada   +4 more
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Pyro Q-CpG™: quantitative analysis of methylation in multiple CpG sites by Pyrosequencing® [PDF]

Nature Methods, 2005
R. J. England, M Pettersson
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Collaborations between CpG sites in DNA methylation [PDF]

International Journal of Modern Physics B, 2017
DNA methylation patterns have profound impacts on genome stability, gene expression, and development. The molecular base of DNA methylation patterns has long been focused at single CpG sites level. Here, we construct a kinetic model of DNA methylation with collaborations between CpG sites, from which a correlation function was established based on ...
Song, You, Ren, Honglei, Lei, Jinzhi
openaire   +1 more source

Processive Methylation of Hemimethylated CpG Sites by Mouse Dnmt1 DNA Methyltransferase [PDF]

Journal of Biological Chemistry, 2004
DNA methyltransferase Dnmt1 ensures clonal transmission of lineage-specific DNA methylation patterns in a mammalian genome during replication. Dnmt1 is targeted to replication foci, interacts with PCNA, and favors methylating the hemimethylated form of CpG sites.
Giedrius Vilkaitis, Isao Suetake, Saulius Klimašauskas, Shoji Tajima   +3 more
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DNA unmethylome profiling by covalent capture of CpG sites [PDF]

Nature Communications, 2013
Dynamic patterns of cytosine-5 methylation and successive hydroxylation are part of epigenetic regulation in eukaryotes, including humans, which contributes to normal phenotypic variation and disease risk. Here we present an approach for the mapping of unmodified regions of the genome, which we call the unmethylome.
KriukienÄ—, Edita, Labrie, Viviane, Khare, Tarang, UrbanaviÄiÅ«tÄ—, GiedrÄ—, LapinaitÄ—, AudronÄ—, KonceviÄius, Karolis, Li, Daofeng, Wang, Ting, Pai, Shraddha, Ptak, Carolyn, GordeviÄius, Juozas, Wang, Sun-Chong, Petronis, ArtÅ«ras, KlimaÅ¡auskas, Saulius   +13 more
openaire   +3 more sources

Evaluation of single CpG sites as proxies of CpG island methylation states at the genome scale [PDF]

Nucleic Acids Research, 2012
Methylation of a CpG island is a faithful marker of silencing of its associated gene. Different approaches report the methylation status of a CpG island based on the determination of one or a few CpG sites by assuming the homogeneity of methylation along the element.
Víctor Barrera, Miguel A. Peinado
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